scholarly journals Steroids and TRP Channels: A Close Relationship

2020 ◽  
Vol 21 (11) ◽  
pp. 3819
Author(s):  
Karina Angélica Méndez-Reséndiz ◽  
Óscar Enciso-Pablo ◽  
Ricardo González-Ramírez ◽  
Rebeca Juárez-Contreras ◽  
Tamara Rosenbaum ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Cell Function ◽  
Trp Channels ◽  
Protein Complexes ◽  
Transmembrane Protein ◽  
Receptor Potential ◽  
Long Term Effects ◽  
Close Relationship ◽  
Transient Receptor

Transient receptor potential (TRP) channels are remarkable transmembrane protein complexes that are essential for the physiology of the tissues in which they are expressed. They function as non-selective cation channels allowing for the signal transduction of several chemical, physical and thermal stimuli and modifying cell function. These channels play pivotal roles in the nervous and reproductive systems, kidney, pancreas, lung, bone, intestine, among others. TRP channels are finely modulated by different mechanisms: regulation of their function and/or by control of their expression or cellular/subcellular localization. These mechanisms are subject to being affected by several endogenously-produced compounds, some of which are of a lipidic nature such as steroids. Fascinatingly, steroids and TRP channels closely interplay to modulate several physiological events. Certain TRP channels are affected by the typical genomic long-term effects of steroids but others are also targets for non-genomic actions of some steroids that act as direct ligands of these receptors, as will be reviewed here.

scholarly journals Functional Importance of Transient Receptor Potential (TRP) Channels in Neurological Disorders

2021 ◽  
Vol 9 ◽  
Author(s):  
Kihwan Lee ◽  
Youn Yi Jo ◽  
Gehoon Chung ◽  
Jung Hoon Jung ◽  
Yong Ho Kim ◽  
...  
Keyword(s):  
Neurological Disorders ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Protein Complexes ◽  
Transmembrane Protein ◽  
Second Messengers ◽  
Ion Homeostasis ◽  
Receptor Potential ◽  
Functional Roles ◽  
Transient Receptor

Transient receptor potential (TRP) channels are transmembrane protein complexes that play important roles in the physiology and pathophysiology of both the central nervous system (CNS) and the peripheral nerve system (PNS). TRP channels function as non-selective cation channels that are activated by several chemical, mechanical, and thermal stimuli as well as by pH, osmolarity, and several endogenous or exogenous ligands, second messengers, and signaling molecules. On the pathophysiological side, these channels have been shown to play essential roles in the reproductive system, kidney, pancreas, lung, bone, intestine, as well as in neuropathic pain in both the CNS and PNS. In this context, TRP channels have been implicated in several neurological disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and epilepsy. Herein, we focus on the latest involvement of TRP channels, with a special emphasis on the recently identified functional roles of TRP channels in neurological disorders related to the disruption in calcium ion homeostasis.

Structure–functional intimacies of transient receptor potential channels

2009 ◽  
Vol 42 (3) ◽  
pp. 201-246 ◽  
Author(s):  
Ramon Latorre ◽  
Cristián Zaelzer ◽  
Sebastian Brauchi
Keyword(s):  
Transient Receptor Potential ◽  
Trp Channels ◽  
Transmembrane Protein ◽  
Receptor Potential ◽  
Transient Receptor Potential Channels ◽  
Trp Channel ◽  
Structural Determinants ◽  
Structure Information ◽  
High Calcium ◽  
Transient Receptor

AbstractAlthough a unifying characteristic common to all transient receptor potential (TRP) channel functions remains elusive, they could be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. TRP channels constitute a large superfamily of ion channels, and can be grouped into seven subfamilies based on their amino acid sequence homology: the canonical or classic TRPs, the vanilloid receptor TRPs, the melastatin or long TRPs, ankyrin (whose only member is the transmembrane protein 1 [TRPA1]), TRPN after the nonmechanoreceptor potential C (nonpC), and the more distant cousins, the polycystins and mucolipins. Because of their role as cellular sensors, polymodal activation and gating properties, many TRP channels are activated by a variety of different stimuli and function as signal integrators. Thus, how TRP channels function and how function relates to given structural determinants contained in the channel-forming protein has attracted the attention of biophysicists as well as molecular and cell biologists. The main purpose of this review is to summarize our present knowledge on the structure of channels of the TRP ion channel family. In the absence of crystal structure information for a complete TRP channel, we will describe important protein domains present in TRP channels, structure–function mutagenesis studies, the few crystal structures available for some TRP channel modules, and the recent determination of some TRP channel structures using electron microscopy.

scholarly journals Nociceptive TRP Channels and Sex Steroids

2021 ◽  
Author(s):  
Óscar Enciso-Pablo ◽  
Karina Angélica Méndez-Reséndiz ◽  
Tamara Rosenbaum ◽  
Sara Luz Morales-Lázaro
Keyword(s):  
Sensory Neurons ◽  
Sex Steroids ◽  
Essential Role ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Environmental Signals ◽  
Nonselective Cation Channels ◽  
Close Relationship ◽  
Transient Receptor

Proteins belonging to Transient Receptor Potential (TRP) family are nonselective cation channels that play an essential role in mammalian physiology, functioning as transducers of several environmental signals including those of chemical, thermal and mechanical natures. A subgroup of these receptors is expressed in sensory neurons where they are activated by noxious stimuli and are key players of pain responses in the organism. Some TRP channels are molecular targets for the classical and non-classical effects of sex steroids. This chapter will describe the close relationship between nociceptive TRP channels and sex steroids as well as their impact on nociception and pain-related responses.

Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses

2011 ◽  
Vol 110 (3) ◽  
pp. 789-798 ◽  
Author(s):  
Kaori Ono ◽  
Masako Tsukamoto-Yasui ◽  
Yoshiko Hara-Kimura ◽  
Naohiko Inoue ◽  
Yoshihito Nogusa ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Low Frequency ◽  
Receptor Potential ◽  
Transient Receptor Potential Channel ◽  
Intragastric Administration ◽  
Brown Adipose ◽  
Reflex Arc ◽  
Transient Receptor

The sympathetic thermoregulatory system controls the magnitude of adaptive thermogenesis in correspondence with the environmental temperature or the state of energy intake and plays a key role in determining the resultant energy storage. However, the nature of the trigger initiating this reflex arc remains to be determined. Here, using capsiate, a digestion-vulnerable capsaicin analog, we examined the involvement of specific activation of transient receptor potential (TRP) channels within the gastrointestinal tract in the thermogenic sympathetic system by measuring the efferent activity of the postganglionic sympathetic nerve innervating brown adipose tissue (BAT) in anesthetized rats. Intragastric administration of capsiate resulted in a time- and dose-dependent increase in integrated BAT sympathetic nerve activity (SNA) over 180 min, which was characterized by an emergence of sporadic high-activity phases composed of low-frequency bursts. This increase in BAT SNA was abolished by blockade of TRP channels as well as of sympathetic ganglionic transmission and was inhibited by ablation of the gastrointestinal vagus nerve. The activation of SNA was delimited to BAT and did not occur in the heart or pancreas. These results point to a neural pathway enabling the selective activation of the central network regulating the BAT SNA in response to a specific stimulation of gastrointestinal TRP channels and offer important implications for understanding the dietary-dependent regulation of energy metabolism and control of obesity.

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