scholarly journals Circulating Tumour Cells as Prognostic Biomarkers in Colorectal Cancer: A Systematic Review

2021 ◽  
Vol 22 (8) ◽  
pp. 3437
Author(s):  
Léa Veyrune ◽  
David N. Naumann ◽  
Niki Christou

Despite therapeutic advances, colorectal cancer (CRC) is still one of the deadliest cancers, partly due to local recurrence and metastatic disease. Tumour cells that spread by gaining access to peripheral blood are called circulating tumour cells (CTCs). These may be present before there are any clinical signs, but can be detected within blood samples. CTCs from patients with CRC may be isolated in a laboratory for characterization and multiple analyses. In this review, we focus on the prognostic potential of CTCs detection, by evaluating the reported progress and applications of such analyses. Our search found 77 relevant studies that reported CTC detection in CRC. Both cell count and features were reported as promising prognosis biomarkers. Since CTCs are rare and can lose their differentiation, new tools are being developed to improve detection. CTCs may have potential as prognostic biomarkers for CRC in terms of survival prediction, anticipating chemotherapy resistance, and surgical planning. CTCs are not yet used in clinical practice, and further investigations are required in order to better frame their practical value.

2021 ◽  
Vol 22 (4) ◽  
pp. 2067
Author(s):  
Rhynelle S. Dmello ◽  
Sarah Q. To ◽  
Ashwini L. Chand

Liver metastasis is the primary contributor to the death of patients with colorectal cancer. Despite the overall success of current treatments including targeted therapy, chemotherapy, and immunotherapy combinations in colorectal cancer patients, the prognosis of patients with liver metastasis remains poor. Recent studies have highlighted the importance of the tumour microenvironment and the crosstalk within that determines the fate of circulating tumour cells in distant organs. Understanding the interactions between liver resident cells and tumour cells colonising the liver opens new therapeutic windows for the successful treatment of metastatic colorectal cancer. Here we discuss critical cellular interactions within the tumour microenvironment in primary tumours and in liver metastases that highlight potential therapeutic targets. We also discuss recent therapeutic advances for the treatment of metastatic colorectal cancer.


2010 ◽  
Vol 14 (8) ◽  
pp. 2073-2077 ◽  
Author(s):  
Paola Gazzaniga ◽  
Angela Gradilone ◽  
Arianna Petracca ◽  
Chiara Nicolazzo ◽  
Cristina Raimondi ◽  
...  

2020 ◽  
Author(s):  
Haijiao Yu ◽  
Ling Ma ◽  
Yubing Zhu ◽  
Wenxia Li ◽  
Lei Ding ◽  
...  

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