Current Understanding of the Relationship between Blood Donor Variability and Blood Component Quality

While differences among donors has long challenged meeting quality standards for the production of blood components for transfusion, only recently has the molecular basis for many of these differences become understood. This review article will examine our current understanding of the molecular differences that impact the quality of red blood cells (RBC), platelets, and plasma components. Factors affecting RBC quality include cytoskeletal elements and membrane proteins associated with the oxidative response as well as known enzyme polymorphisms and hemoglobin variants. Donor age and health status may also be important. Platelet quality is impacted by variables that are less well understood, but that include platelet storage sensitive metabolic parameters, responsiveness to agonists accumulating in storage containers and factors affecting the maintenance of pH. An increased understanding of these variables can be used to improve the quality of blood components for transfusion by using donor management algorithms based on a donors individual molecular and genetic profile.

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Perbedaan PERBEDAAN NILAI LEKOSIT ANTARA KOMPONEN DARAH PACKED RED CELLS (PRC) DAN PACKED RED CELLS LEUCODEPLETED (PRC-LD) DI UTD PMI KOTA SURABAYA TAHUN 2019

Klinikal Sains : Jurnal Analis Kesehatan ◽

10.36341/klinikal_sains.v9i2.1994 ◽

2021 ◽

Vol 9 (2) ◽

pp. 106-111

Author(s):

Renata Primasari

Keyword(s):

Comparative Study ◽

Red Cells ◽

Blood Component ◽

Blood Transfusions ◽

Blood Components ◽

European Standard ◽

The Difference ◽

The Relationship ◽

Transfusion Reactions

Abstract This leukodepleted PRC (PRC-LD) is considered capable of preventing reactions related to blood transfusions because it contains only a small number of leukocytes. The blood component of PRC-LD has also been shown to prevent or reduce transfusion reactions. Leukodepleted is a procedure to reduce the number of leukocytes in the blood or blood components to be transfused to a minimum of <1x106 leukocytes/unit (European standard) or reduce the number of leukocytes >99%. The purpose of this study was to see the difference in leukocyte values in the PRC and PRC-LD components. The method used is analytic, namely research that aims to determine the relationship between variables within the scope of the laboratory. The method used is a comparative study. This study used 30 samples of PRC products and 30 samples of Leucodepleted PRC products at UTD PMI Surabaya City with 450 cc bags. The study was conducted in October - December 2019. The result was that the leukocyte value in the PRC blood component contained blood quality that did not meet the specifications as many as 30 bags (100%) had leukocyte levels >1x106 per bag. Meanwhile, the blood component of PRC-LD contains blood quality that meets the specifications as many as 30 bags (100%), having leukocyte levels <1x106 per bag. Conclusion The quality of PRC Leukodepleted blood component products, the quality of leukocyte levels that meet the specifications, there are 30 blood bags (100%). Keywords: Packed Red Cells Leukodepleted

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MicroRNAs as a Potential Quality Measurement Tool of Platelet Concentrate Stored in Blood Banks—A Review

Cells ◽

10.3390/cells8101256 ◽

2019 ◽

Vol 8 (10) ◽

pp. 1256 ◽

Cited By ~ 4

Author(s):

Jersey Heitor da Silva Maués ◽

Caroline de Fátima Aquino Moreira-Nunes ◽

Rommel Mário Rodriguez Burbano

Keyword(s):

Molecular Mechanisms ◽

Quality Measurement ◽

Storage Conditions ◽

Platelet Concentrate ◽

Measurement Tool ◽

Blood Component ◽

Public And Private ◽

Platelet Storage ◽

Blood Banks

Background: Platelet concentrate (PC) is one of the main products used in a therapeutic transfusion. This blood component requires special storage at blood banks, however, even under good storage conditions, modifications or degradations may occur and are known as platelet storage lesions. Methods: This research was performed on scientific citation databases PubMed/Medline, ScienceDirect, and Web of Science, for publications containing platelet storage lesions. The results obtained mainly reveal the clinical applicability of miRNAs as biomarkers of storage injury and as useful tools for a problem affecting public and private health, the lack of PC bags in countries with few blood donors. The major studies listed in this review identified miRNAs associated with important platelet functions that are relevant in clinical practice as quality biomarkers of PC, such as miR-223, miR-126, miR-10a, miR-150, miR-16, miR-21, miR-326, miR-495, let-7b, let-7c, let-7e, miR-107, miR-10b, miR-145, miR-155, miR-17, miR-191, miR-197, miR-200b, miR-24, miR-331, miR-376. These miRNAs can be used in blood banks to identify platelet injury in PC bags. Conclusion: The studies described in this review relate the functions of miRNAs with molecular mechanisms that result in functional platelet differences, such as apoptosis. Thus, miRNA profiles can be used to measure the quality of storage PC for more than 5 days, identify bags with platelet injury, and distinguish those with functional platelets.

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Customer’s satisfaction on service quality at Vietnam Technological and Commercial Joint Stock Bank – An Giang Branch

Science & Technology Development Journal - Economics - Law and Management ◽

10.32508/stdjelm.v4i3.564 ◽

2020 ◽

Vol 4 (3) ◽

pp. First

Author(s):

Tran Minh Hieu ◽

Nguyen Duong Ngoc Mai Chi

Keyword(s):

Customer Satisfaction ◽

Service Quality ◽

Test Method ◽

Quality Of Services ◽

Factors Affecting ◽

Factors Influencing ◽

Alpha Reliability ◽

Survey Results ◽

Development Orientation

This study applied SERVQUAL scale of Parasuraman et al to measure factors affecting customer satisfaction on service quality at Vietnam Technological and Commercial Joint Stock Bank - An Giang Branch (Techcombank An Giang). The study was conducted to survey 207 customers who have been using the service at Techcombank An Giang. The survey results were analyzed by the Cronbach's Alpha reliability test method, then used Exploratory factor analysis (EFA) to verify and evaluate the scale of service quality. The results of the regression analysis show that customer's satisfaction about service quality at Techcombank An Giang includes four factors: The factor with the highest level is the Empathy with Beta = 0.253, the second of factor is the Responsibility with Beta = 0.248, ranked third in the influence level is the Tangible with Beta = 0.235, and the lowest impact level is the Reliability with Beta = 0.144. The research also uses statistical methods to describe and test the differences of demographic factors with customer's satisfactionon service quality.The analysis results show that there is no difference between customer's satisfaction on service quality and factors such as gender, age, income, number of transaction banks, regular transaction banks, and time to use the service at Techcombank An Giang. Through the research results, the author would like to propose some ideas to improve the quality of services, thereby attracting new customers and importantly, keeping traditional customers because the development orientation of Techcombank is to take care of old customers to cross sell other products of the bank. The Stud results offer a basis for the branch to identify the factors influencing customer satisfaction on their service quality, thereby having an appropriate strategy to improve customer satisfaction.

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"A Study on the Factors Affecting the Quality of Employment for Persons with Hearing Impairment*"

JOURNAL OF SPECIAL EDUCATION & REHABILITATION SCIENCE ◽

10.23944/jsers.2018.06.57.2.16 ◽

2018 ◽

Vol 57 (2) ◽

pp. 357-383

Author(s):

Seung-Mi Ha ◽

Dal-Yob Lee

Keyword(s):

Hearing Impairment ◽

Factors Affecting

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THE STUDY ON TA VAT WINE PRODUCTION FROM SUGAR PALM (ARENGA PINNATA) SAP

HUE UNIVERSITY JOURNAL OF SCIENCE AGRICULTURE AND RURAL DEVELOPMENT ◽

10.26459/jard.v83i5.3080 ◽

2014 ◽

Vol 83 (5) ◽

Author(s):

Nguyễn Thị Hồng Thu ◽

Đặng Minh Nhật ◽

Nguyễn Hoàng Dung

Keyword(s):

Room Temperature ◽

Fermentation Process ◽

Inoculum Size ◽

Wine Fermentation ◽

Wine Production ◽

Factors Affecting ◽

Natural Fermentation ◽

Tropical Asia ◽

Best Parameters

Sugar palm (Arenga pinnata) is a feather palm native to tropical Asia. In Vietnam, it is named Búng Báng or Đoác and grown only on the highlands in the central or northern part of Vietnam. It is utilized for many purposes, especially for Ta Vat wine production - a characteristic and unique product of Co Tu ethnic minority. However, because of the natural fermentation used in the production, the product quality is inconsistent. The purpose of this study was to examine a new procedure of using palm sap for making Ta Vat wine. Some characteristics of the sap, which was collected at Nam Giang district, Quang Nam province are determined, proving the potential of the sap for making wine product. The quality of sap changes quickly at room temperature. At low temperature (4 - 60C), the changes in sap quality are apparently slower. Examining some factors affecting its quality during the wine fermentation process, we determined the best parameters for the fermentation process as follows: inoculum size of 3% with cell density of about 1x108 cells/ml, the addition of the extract from the bark of Ceylon ironwood (Mesua ferrea L.) 4%. Keywords: Arenga pinnata, sap, Ceylon ironwood bark, Mesua ferrea L., wine fermentation.

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