scholarly journals Functionalization of Synthetic Bone Substitutes

2021 ◽  
Vol 22 (9) ◽  
pp. 4412
Author(s):  
André Busch ◽  
Marcus Jäger ◽  
Constantin Mayer ◽  
Andrea Sowislok
Keyword(s):  
Bone Healing ◽  
Bone Substitutes ◽  
Future Perspectives ◽  
Synthetic Bone ◽  
Long Time ◽  
Osseous Defects

Bone substitutes have been applied to treat osseous defects for a long time. To prevent implant related infection (IRI) and enhance bone healing functionalized biomaterials, antibiotics and osteoinductive substances have been introduced. This study gives an overview of the current available surface-coated bone substitutes and provides an outlook for future perspectives.

Bone Substitutes in Orthopaedic Surgery: Current Status and Future Perspectives

2020 ◽  
Author(s):  
André Busch ◽  
Alexander Wegner ◽  
Marcel Haversath ◽  
Marcus Jäger
Keyword(s):  
Donor Site ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Donor Site Morbidity ◽  
Current Status ◽  
Future Perspectives ◽  
Autologous Bone Grafting ◽  
Long Time ◽  
Autologous Bone ◽  
Autologous Bone Grafts

AbstractBone replacement materials have been successfully supplied for a long time. But there are cases, especially in critical sized bone defects, in which the therapy is not sufficient. Nowadays, there are multiple bone substitutes available. Autologous bone grafts remain the “gold standard” in bone regeneration. Yet, donor-site morbidity and the available amount of sufficient material are limitations for autologous bone grafting. This study aimed to provide information about the current status in research regarding bone substitutes. We report on the advantages and drawbacks of several bone substitutes. At the end, we discuss the current developments of combining ceramic substitutes with osteoinductive substances.

Osteoconductivity and biodegradation of synthetic bone substitutes with different tricalcium phosphate contents in rabbits

2013 ◽  
Vol 102 (1) ◽  
pp. 80-88 ◽  
Author(s):  
Cheryl Yang ◽  
Otgonbayar Unursaikhan ◽  
Jung-Seok Lee ◽  
Ui-Won Jung ◽  
Chang-Sung Kim ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Bone Substitutes ◽  
Synthetic Bone

scholarly journals Synthetic Bone Substitutes and Mechanical Devices for the Augmentation of Osteoporotic Proximal Humeral Fractures: A Systematic Review of Clinical Studies

2020 ◽  
Vol 11 (2) ◽  
pp. 29 ◽  
Author(s):  
Giuseppe Marongiu ◽  
Marco Verona ◽  
Gaia Cardoni ◽  
Antonio Capone
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Calcium Sulfate ◽  
Bone Substitutes ◽  
Proximal Humeral Fractures ◽  
Humeral Fractures ◽  
Cochrane Library ◽  
Synthetic Bone ◽  
Mechanical Devices ◽  
Pmma Cement

Background: Different augmentation techniques have been described in the literature in addition to the surgical treatment of proximal humeral fractures. The aim of this systematic review was to analyze the use of cements, bone substitutes, and other devices for the augmentation of proximal humeral fractures. Methods: A systematic review was conducted by using PubMed/MEDLINE, ISI Web of Knowledge, Cochrane Library, Scopus/EMBASE, and Google Scholar databases according the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines over the years 1966 to 2019. The search term “humeral fracture proximal” was combined with “augmentation”; “polymethylmethacrylate, PMMA”; “cement”; “bone substitutes”; “hydroxyapatite”; “calcium phosphates”; “calcium sulfate”; “cell therapies”, and “tissue engineering” to find the literature relevant to the topic under review. Results: A total of 10 clinical studies considered eligible for the review, with a total of 308 patients, were included. Mean age at the time of injury was 68.8 years (range of 58–92). The most commonly described techniques were reinforcing the screw–bone interface with bone PMMA cement (three studies), filling the metaphyseal void with synthetic bone substitutes (five studies), and enhancing structural support with metallic devices (two studies). Conclusion: PMMA cementation could improve screw-tip fixation. Calcium phosphate and calcium sulfate injectable composites provided good biocompatibility, osteoconductivity, and lower mechanical failure rate when compared to non-augmented fractures. Mechanical devices currently have a limited role. However, the available evidence is provided mainly by level III to IV studies, and none of the proposed techniques have been sufficiently studied.

Advances in the smart materials applications in the aerospace industries

2020 ◽  
Vol 92 (7) ◽  
pp. 1027-1035 ◽  
Author(s):  
Al Arsh Basheer
Keyword(s):  
Smart Materials ◽  
Design Methodology ◽  
Extensive Study ◽  
Future Perspectives ◽  
Intelligent Materials ◽  
Content Type ◽  
Recent Developments ◽  
Long Time ◽  
Working Principle ◽  
Online Library

Purpose Smart materials also called intelligent materials are gaining importance continuously in many industries including aerospace one. It is because of the unique features of these materials such as self-sensing, self-adaptability, memory capabilities and manifold functions. For a long time, there is no review of smart materials. Therefore, it is considered worthwhile to write a review on this subject. Design/methodology/approach A thorough search of the literature was carried out through SciFinder, ScienceDirect, SpringerLink, Wiley Online Library and reputed and peer-reviewed journals. The literature was critically analyzed and a review was written. Findings This study describes the advances in smart materials concerning their applications in aerospace industries. The classification, working principle and recent developments (nano-smart materials) of smart materials are discussed. Besides, the future perspectives of these materials are also highlighted. Much research has not been done in this area, which needs more extensive study. Originality/value Certainly, this study will be highly useful for academicians, researchers and technocrats working in aerospace industries.

scholarly journals Review Article: Zirconia surface bone graft implant with Ultraviolet Stimulation works toward Accelerating Bone Healing

2019 ◽  
Vol 7 (11_suppl6) ◽  
pp. 2325967119S0046
Author(s):  
Adriel Benedict Haryono ◽  
Yoyos Dias Ismiarto
Keyword(s):  
Literature Review ◽  
Bone Healing ◽  
Bone Growth ◽  
Cell Attachment ◽  
Biomedical Application ◽  
Tetragonal Zirconia ◽  
Ceramic Materials ◽  
Bone Grafts ◽  
Bone Substitutes ◽  
Transformation Toughening

Biomedical zirconia was introduced in 1969 into medicine to solve the problem of alumina brittleness in hip replacement procedures and has since been used for various joint replacement appliances in orthopedic surgery. The most frequently-studied material is yttrium-stabilized zirconia, which is also known as tetragonal zirconia polycrystal (TZP). Y-TZP presents various interesting characteristics, such as low porosity, high density and high bending and compression strength, proving that it is suitable for biomedical application. UV-treated zirconia surfaces exhibited an enhanced osteoblast response, which was characterized by an accelerated and augmented cell attachment, accelerated cell spread and cytoskeletal development with increased proliferation. The purpose of this paper is to identify which method of treatment of zirconia material implant & ultraviolet stimulation effect for bone healing is the most effective and efficient based on literature review. Bone grafts are available in a variety of substances. These bone substitutes can be biological (natural) or synthetic. Re-absorption is also essential for bone growth. Specific cells continuously break down bones and rebuild them. Substitutes that break down too quickly are not suitable for bone grafts, as they do not allow enough time for the new bone to grow. From our literature review, Zirconia is one of the biomaterials that have a bright future because of its high mechanical strength and fracture toughness. Zirconia ceramics have several advantages over other ceramic materials due to the transformation toughening mechanisms operating in their microstructure that can be expressed in components made out of them. UV treatment substantially enhances the osteogenesis process, resulting in a greater amount of peri-implant bone, as well as an increased strength of bone-zirconia integration.

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