scholarly journals Advances in Nanoparticle Drug Delivery Systems for Anti-Hepatitis B Virus Therapy: A Narrative Review

2021 ◽  
Vol 22 (20) ◽  
pp. 11227
Author(s):  
Jing Miao ◽  
Peng Gao ◽  
Qian Li ◽  
Kaifeng He ◽  
Liwen Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Drug Targets ◽  
Drug Delivery Systems ◽  
Relevant Literature ◽  
Viral Disease ◽  
Delivery Systems ◽  
B Virus ◽  
Nanoparticle Drug Delivery

Chronic hepatitis B (CHB) is an infectious viral disease that is prevalent worldwide. Traditional nucleoside analogues, as well as the novel drug targets against hepatitis B virus (HBV), are associated with certain critical factors that influence the curative effect, such as biological stability and safety, effective drug delivery, and controlled release. Nanoparticle drug delivery systems have significant advantages and have provided a basis for the development of anti-HBV strategies. In this review, we aim to review the advances in nanoparticle drug delivery systems for anti-hepatitis B virus therapy by summarizing the relevant literature. First, we focus on the characteristics of nanoparticle drug delivery systems for anti-HBV therapy. Second, we discuss the nanoparticle delivery systems for anti-HBV nucleoside drugs, gene-based drugs, and vaccines. Lastly, we provide an overview of the prospects for nanoparticle-based anti-HBV agents.

Drug Delivery Systems and Liver Targeting for the Improved Pharmacotherapy of the Hepatitis B Virus (HBV) Infection

2010 ◽  
Vol 27 (7) ◽  
pp. 1184-1202 ◽  
Author(s):  
María L. Cuestas ◽  
Verónica L. Mathet ◽  
José R. Oubiña ◽  
Alejandro Sosnik
Keyword(s):  
Drug Delivery ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Hbv Infection ◽  
Liver Targeting ◽  
B Virus

Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine

2014 ◽  
Vol 3 (2) ◽  
pp. 105-118 ◽  
Author(s):  
Pedro Martins ◽  
Daniela Rosa ◽  
Alexandra Fernandes ◽  
Pedro V. Baptista
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanoparticle Drug Delivery

scholarly journals Micro and nanoparticle drug delivery systems for preventing allotransplant rejection

2015 ◽  
Vol 160 (1) ◽  
pp. 24-35 ◽  
Author(s):  
James D. Fisher ◽  
Abhinav P. Acharya ◽  
Steven R. Little
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanoparticle Drug Delivery

scholarly journals Nanoparticle Drug Delivery Systems for α-Mangostin

2020 ◽  
Vol Volume 13 ◽  
pp. 23-36 ◽  
Author(s):  
Nasrul Wathoni ◽  
Agus Rusdin ◽  
Keiichi Motoyama ◽  
I Made Joni ◽  
Ronny Lesmana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanoparticle Drug Delivery

scholarly journals Targeted Drug Delivery Systems for the Treatment of Glaucoma: Most Advanced Systems Review

Polymers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1742 ◽  
Author(s):  
Olga Cegielska ◽  
Paweł Sajkiewicz
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Targeted Delivery ◽  
Drug Targets ◽  
Drug Delivery Systems ◽  
Release Kinetics ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Drug Bioavailability

Each year, new glaucoma drug delivery systems are developed. Due to the chronic nature of the disease, it requires the inconvenient daily administration of medications. As a result of their elution from the eye surface and penetration to the bloodstream through undesired permeation routes, the bioavailability of active compounds is low, and systemic side effects occur. Despite numerous publications on glaucoma drug carriers of controlled drug release kinetics, only part of them consider drug permeation routes and, thus, carriers’ location, as an important factor affecting drug delivery. In this paper, we try to demonstrate the importance of the delivery proximal to glaucoma drug targets. The targeted delivery can significantly improve drug bioavailability, reduce side effects, and increase patients’ compliance compared to both commercial and scientifically developed formulations that can spread over the eye surface or stay in contact with conjunctival sac. We present a selection of glaucoma drug carriers intended to be placed on cornea or injected into the aqueous humor and that have been made by advanced materials using hi-tech forming methods, allowing for effective and convenient sustained antiglaucoma drug delivery.

scholarly journals Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 640 ◽  
Author(s):  
Jihye Yoo ◽  
Changhee Park ◽  
Gawon Yi ◽  
Donghyun Lee ◽  
Heebeom Koo
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Small Molecules ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Active Targeting ◽  
Target Cells ◽  
Specific Receptors ◽  
Nanoparticle Drug Delivery

Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as drug delivery systems. Along with optimization of physicochemical properties, researchers have focused on surface modification of NPs with biological ligands. Such ligands can bind specific receptors on the surface of target cells. Furthermore, biological ligands can facilitate uptake of modified NPs, which is referred to as ‘active targeting’ of NPs. In this review, we discuss recent applications of biological ligands including proteins, polysaccharides, aptamers, peptides, and small molecules for NP-mediated drug delivery. We prioritized studies that have demonstrated targeting in animals over in vitro studies. We expect that this review will assist biomedical researchers working with NPs for drug delivery and imaging.

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