scholarly journals Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage

2021 ◽  
Vol 22 (22) ◽  
pp. 12306
Author(s):  
Radim Vrzal
Keyword(s):  
Lung Cancer ◽  
Transcriptional Regulation ◽  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Genetic Polymorphisms ◽  
Significant Role ◽  
Lung Damage ◽  
Basic Knowledge ◽  
Pulmonary Lesions ◽  
Enzymatic Characteristics

Cytochrome P450 2A13 is an omitted brother of CYP2A6 that has an important role in the drug metabolism of liver. Due to extrahepatic expression, it has gained less attention than CYP2A6, despite the fact that it plays a significant role in toxicant-induced pulmonary lesions and, therefore, lung cancer. The purpose of this mini-review is to summarize the basic knowledge about this enzyme in relation to the substrates, inhibitors, genetic polymorphisms, and transcriptional regulation that are known so far (September 2021).

scholarly journals Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer

2017 ◽  
Vol 39 (1) ◽  
Author(s):  
Nada Ezzeldin ◽  
Dalia El-Lebedy ◽  
Amira Darwish ◽  
Ahmed El-Bastawisy ◽  
Mirhane Hassan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cytochrome P450 ◽  
Genetic Polymorphisms ◽  
Egyptian Population ◽  
Human Cytochrome

scholarly journals Genetic polymorphisms of CYP2C9, CYP2C19, and CYP3A5 in Kosovar population

2017 ◽  
Vol 68 (3) ◽  
pp. 180-184 ◽  
Author(s):  
Valon Krasniqi ◽  
Aleksandar Dimovski ◽  
Hasime Qorraj Bytyqi ◽  
Aleksandar Eftimov ◽  
Livija Šimičević ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Gene Family ◽  
Genetic Polymorphisms ◽  
Poor Metabolisers ◽  
Southeast Europe ◽  
Individual Variations ◽  
Different Populations ◽  
Variant Alleles ◽  
Important Variant

Abstract Cytochrome P450 genetic polymorphisms are responsible for individual variations in drug metabolism and drug-drug interactions. They are very important for pharmacogenetics, and their frequency varies across different populations. There is a big gap in the knowledge about the CYP gene family polymorphisms in the population of Kosovo, and the aim of our study was to fill that gap by determining the frequency of the most important variant alleles of CYP2C9, CYP2C19, and CYP3A5 in 234 nonrelated Kosovars. The allele frequencies of CYP2C9*2 and 2C9*3 were 17.52 %, and 10.89 %, respectively. Sixteen participants (6.81 %) were CYP2C9 poor metabolisers. The CYP2C19*2 and *17 variant frequencies were 13.03 % and 19.01 %, respectively. There were 2.13 % CYP2C19 poor and 4.27 % ultra-rapid metabolisers (homozygous carriers of the *17 allele). With regard to CYP3A5, the frequency of the *3 variant allele was 98.29 % (non-expressors), while the remaining participants (1.70 %) were expressors of CYP3A5. These findings are comparable with other European ethnicities, specifically those of Southeast Europe.

Genetic polymorphisms in cytochrome P450 oxidoreductase influence microsomal P450-catalyzed drug metabolism

2008 ◽  
Vol 18 (1) ◽  
pp. 11-24 ◽  
Author(s):  
Steven N. Hart ◽  
Shuang Wang ◽  
Kaori Nakamoto ◽  
Christopher Wesselman ◽  
Ye Li ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Genetic Polymorphisms ◽  
P450 Oxidoreductase ◽  
Cytochrome P450 Oxidoreductase

Biology of Heme: Drug Interactions and Adverse Drug Reactions with CYP450

2019 ◽  
Vol 18 (23) ◽  
pp. 2042-2055 ◽  
Author(s):  
Neeraj Kumar ◽  
Heerak Chugh ◽  
Damini Sood ◽  
Snigdha Singh ◽  
Aarushi Singh ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Drug Interactions ◽  
Adverse Drug Reactions ◽  
Genetic Defects ◽  
Drug Reactions ◽  
Detailed Structure ◽  
Synthesis And Degradation ◽  
Porphyrin Rings

Heme is central to functions of many biologically important enzymes (hemoproteins). It is an assembly of four porphyrin rings joined through methylene bridges with a central Fe (II). Heme is present in all cells, and its synthesis and degradation balance its amount in the cell. The deregulations of heme networks and incorporation in hemoproteins lead to pathogenic state. This article addresses the detailed structure, biosynthesis, degradation, and transportation associated afflictions to heme. The article is followed by its roles in various diseased conditions where it is produced mainly as the cause of increased hemolysis. It manifests the symptoms in diseases as it is a pro-oxidant, pro-inflammatory and pro-hemolytic agent. We have also discussed the genetic defects that tampered with the biosynthesis, degradation, and transportation of heme. In addition, a brief about the largest hemoprotein group of enzymes- Cytochrome P450 (CYP450) has been discussed with its roles in drug metabolism.

P-300 Genetic polymorphisms of N-acetyltransferase 2 (NAT2) andL-myc can evaluate lung cancer susceptibility by smoking

Lung Cancer ◽  
2005 ◽  
Vol 49 ◽  
pp. S193-S194
Author(s):  
Y. Ohsawa ◽  
J. Takahashi ◽  
N. Inoue ◽  
C. Takahata ◽  
K. Yoshida ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Genetic Polymorphisms ◽  
Cancer Susceptibility ◽  
Lung Cancer Susceptibility
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