scholarly journals Increased Frequency of Copy Number Variations Revealed by Array Comparative Genomic Hybridization in the Offspring of Male Mice Exposed to Low Dose-Rate Ionizing Radiation

2021 ◽  
Vol 22 (22) ◽  
pp. 12437
Author(s):  
Keiji Ogura ◽  
Yoshiko Ayabe ◽  
Chihiro Harada ◽  
Ignacia Braga Tanaka ◽  
Satoshi Tanaka ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
Copy Number ◽  
Array Comparative Genomic Hybridization ◽  
Low Dose ◽  
De Novo ◽  
Copy Number Variations ◽  
Comparative Genomic ◽  
Male Mice ◽  
Low Dose Rate

There is very little information on the transgenerational or genetic effects of low dose-rate ionizing radiation. We report the detection of the transgenerational effects of chronic low dose-rate irradiation in mice, at the molecular level in the whole genome, using array comparative genomic hybridization technology. We observed that the number of the mice with de novo copy number variations (specifically, deletions) was significantly increased in the offspring of C57BL/6J male mice exposed to 20 mGy/day gamma-rays for 400 days (total dose: 8000 mGy), as compared to non-irradiated controls. We did not detect any difference in the size of the de novo deletions between the irradiated and the non-irradiated groups. An analysis of the life span of the offspring suggested a possibility that de novo copy-number variations may be associated with shorter life spans.

Using a Temperature-Switching Approach to Evaluate Low-Dose-Rate Ionizing Radiation Effects on SET in Linear Bipolar Circuits

2019 ◽  
Vol 66 (7) ◽  
pp. 1557-1565 ◽  
Author(s):  
Shuai Yao ◽  
Wu Lu ◽  
Xin Yu ◽  
Qi Guo ◽  
Chengfa He ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
Radiation Effects ◽  
Low Dose ◽  
Low Dose Rate

scholarly journals The Effects of Low Dose-Rate Ionizing Radiation on the Shapes of Transients in the L>M124 Operational Amplifier

2008 ◽  
Vol 55 (6) ◽  
pp. 3314-3320 ◽  
Author(s):  
Stephen Buchner ◽  
Dale McMorrow ◽  
Nicholas Roche ◽  
Laurent Dusseau ◽  
Ron L. Pease
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
Operational Amplifier ◽  
Low Dose ◽  
Low Dose Rate

Effects of a very low dose rate of chronic ionizing radiation on the division potential of human embryonic lung fibroblasts in vitro

1986 ◽  
Vol 21 (1) ◽  
pp. 1-11 ◽  
Author(s):  
F. Croute ◽  
S. Vidal ◽  
J.P. Soleilhavoup ◽  
C. Vincent ◽  
G. Serre ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
Low Dose ◽  
Lung Fibroblasts ◽  
Embryonic Lung ◽  
Human Embryonic Lung ◽  
Low Dose Rate

scholarly journals Gamma Low-Dose-Rate Ionizing Radiation Stimulates Adaptive Functional and Molecular Response in Human Aortic Endothelial Cells in a Threshold-, Dose-, and Dose Rate–Dependent Manner

Dose-Response ◽  
2018 ◽  
Vol 16 (1) ◽  
pp. 155932581875523 ◽  
Author(s):  
Juliana Vieira Dias ◽  
Celine Gloaguen ◽  
Dimitri Kereselidze ◽  
Line Manens ◽  
Karine Tack ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Cells ◽  
Ionizing Radiation ◽  
Dose Rate ◽  
Low Dose ◽  
Human Aorta ◽  
Dependent Manner ◽  
Inflammatory Genes ◽  
Low Dose Rate ◽  
Anti Inflammatory

A central question in radiation protection research is whether low-dose and low-dose-rate (LDR) exposures to ionizing radiation play a role in progression of cardiovascular disease. The response of endothelial cells to different LDR exposures may help estimate risk of cardiovascular disease by providing the biological mechanism involved. We investigated the effect of chronic LDR radiation on functional and molecular responses of human aorta endothelial cells (HAoECs). Human aorta endothelial cells were continuously irradiated at LDR (6 mGy/h) for 15 days and analyzed at time points when the cumulative dose reached 0.05, 0.5, 1.0, and 2.0 Gy. The same doses were administered acutely at high-dose rate (HDR; 1 Gy/min). The threshold for the loss of angiogenic capacity for both LDR and HDR radiations was between 0.5 and 1.0 Gy. At 2.0 Gy, angiogenic capacity returned to normal only for HAoEC exposed to LDR radiation, associated with increased expression of antioxidant and anti-inflammatory genes. Pre-LDR, but not pre-HDR, radiation, followed by a single acute 2.0 Gy challenge dose sustained the expression of antioxidant and anti-inflammatory genes and stimulated angiogenesis. Our results suggest that dose rate is important in cellular response and that a radioadaptive response is involved for a 2.0 Gy dose at LDR.

scholarly journals Association between low doses of ionizing radiation, administered acutely or chronically, and time to onset of stroke in a rat model

2020 ◽  
Vol 61 (5) ◽  
pp. 666-673
Author(s):  
Norio Takahashi ◽  
Munechika Misumi ◽  
Hideko Murakami ◽  
Yasuharu Niwa ◽  
Waka Ohishi ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Radiation Exposure ◽  
Dose Rate ◽  
Low Dose ◽  
Gamma Ray ◽  
Spontaneously Hypertensive Rat ◽  
Onset Time ◽  
High Sensitivity ◽  
Low Dose Rate ◽  
Model Animal

Abstract Exposure to high-doses of ionizing radiation has been reported to be associated with the risk of stroke. However, risks associated with lower dose exposures remain unclear, and there is little information available for the risk modification according to the dose-rate. There are few studies using animal models which might be able to provide complementary information on this association. In this study, the male stroke-prone spontaneously hypertensive rat (SHRSP) was used as a model animal. The rats were acutely irradiated with doses between 0 and 1.0 Gy or chronically irradiated with a cumulative dose of 0.5 or 1.0 Gy (at a dose rate of 0.05 or 0.1 Gy/day, respectively). The onset time of stroke related symptoms in SHRSP was used as an endpoint for evaluating the effects of low dose and the low dose-rate gamma-ray exposures. With respect to acute exposure, the time to the onset of stroke in the irradiated rats suggested the presence of a threshold around 0.1 Gy. For the low dose-rate chronically exposed, no significant increase in stroke symptom was observed. These findings are novel and demonstrate that the SHRSP system can be used to determine the association between the risk of stroke and radiation exposure with high sensitivity. Moreover, these studies provide important information regarding the association between the low dose and low dose-rate radiation exposure and circulatory diseases, especially stroke.

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