scholarly journals Anti-Inflammatory Function of Fatty Acids and Involvement of Their Metabolites in the Resolution of Inflammation in Chronic Obstructive Pulmonary Disease

2021 ◽  
Vol 22 (23) ◽  
pp. 12803
Author(s):  
Stanislav Kotlyarov ◽  
Anna Kotlyarova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Fatty Acids ◽  
Lipid Metabolism ◽  
Pulmonary Disease ◽  
Unsaturated Fatty Acids ◽  
New Drugs ◽  
Chronic Obstructive ◽  
Resolution Of Inflammation ◽  
Obstructive Pulmonary Disease ◽  
Mediators Of Inflammation

Lipid metabolism plays an important role in many lung functions. Disorders of lipid metabolism are part of the pathogenesis of chronic obstructive pulmonary disease (COPD). Lipids are involved in numerous cross-linkages with inflammation. Recent studies strongly support the involvement of fatty acids as participants in inflammation. They are involved in the initiation and resolution of inflammation, including acting as a substrate for the formation of lipid mediators of inflammation resolution. Specialized pro-inflammatory mediators (SPMs) belonging to the classes of lipoxins, resolvins, maresins, and protectins, which are formed enzymatically from unsaturated fatty acids, are now described. Disorders of their production and function are part of the pathogenesis of COPD. SPMs are currently the subject of active research in order to find new drugs. Short-chain fatty acids are another important participant in metabolic and immune processes, and their role in the pathogenesis of COPD is of great clinical interest.

Dietary intake of fatty acids and its relationship with FEV1/FVC in patients with chronic obstructive pulmonary disease

2019 ◽  
Vol 29 ◽  
pp. 92-96
Author(s):  
Abril Jiménez-Cepeda ◽  
Giselle Dávila-Said ◽  
Arturo Orea-Tejeda ◽  
Dulce González-Islas ◽  
Marcela Elizondo-Montes ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Fatty Acids ◽  
Dietary Intake ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Chemerin: A Potential Regulator of Inflammation and Metabolism for Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation

2020 ◽  
Vol 2020 ◽  
pp. 1-20
Author(s):  
Jian Li ◽  
Yufan Lu ◽  
Ning Li ◽  
Peijun Li ◽  
Zhengrong Wang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lipid Metabolism ◽  
Pulmonary Disease ◽  
Inflammatory Responses ◽  
Therapeutic Interventions ◽  
Chronic Obstructive ◽  
Barrier Dysfunction ◽  
Obstructive Pulmonary Disease ◽  
Glucose And Lipid Metabolism

Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are also closely related to inflammation processes. Further insights into the interactions of inflammation and glucose and lipid metabolism might therefore inspire novel therapeutic interventions to promote lung rehabilitation. Chemerin, as a recently discovered adipokine, has been shown to play a role in inflammatory response and glucose and lipid metabolism in many diseases (including COPD). Chemerin recruits inflammatory cells to sites of inflammation during the early stages of COPD, leading to endothelial barrier dysfunction, early vascular remodeling, and angiogenesis. Moreover, it supports the recruitment of antigen-presenting cells that guide immune cells as part of the body’s inflammatory responses. Chemerin also regulates metabolism via activation of its cognate receptors. Glucose homeostasis is affected via effects on insulin secretion and sensitivity, and lipid metabolism is changed by increased transformation of preadipocytes to mature adipocytes through chemerin-binding receptors. Controlling chemerin signaling may be a promising approach to improve various aspects of COPD-related dysfunction. Importantly, several studies indicate that chemerin expression in vivo is influenced by exercise. Although available evidence is still limited, therapeutic alterations of chemerin activity may be a promising target of therapeutic approaches aimed at the rehabilitation of COPD patients based on exercises. In conclusion, chemerin plays an essential role in COPD, especially in the inflammatory responses and metabolism, and has a potential to become a target for, and a biomarker of, curative mechanisms underlying exercise-mediated lung rehabilitation.

scholarly journals Lipid metabolism in chronic obstructive pulmonary disease

2019 ◽  
Vol Volume 14 ◽  
pp. 1009-1018 ◽  
Author(s):  
Haipin Chen ◽  
Zhouyang Li ◽  
Lingling Dong ◽  
Yinfang Wu ◽  
Huahao Shen ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lipid Metabolism ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease
Sign in / Sign up

Export Citation Format

Share Document