scholarly journals Hormone Replacement Therapy in Endometrial Cancer Survivors: A Meta-Analysis

2021 ◽  
Vol 10 (14) ◽  
pp. 3165
Author(s):  
Ambrogio P. Londero ◽  
Nadia Parisi ◽  
Alice Tassi ◽  
Serena Bertozzi ◽  
Angelo Cagnacci
Keyword(s):  
Endometrial Cancer ◽  
Observational Studies ◽  
Hormone Replacement ◽  
Black American ◽  
Supporting Evidence ◽  
Risk Of Recurrence ◽  
American Women ◽  
Oncological Outcomes ◽  
Black American Women ◽  
Increased Risk

The purpose of this study is to investigate the effect of hormone therapy (HT) on the oncological outcomes of endometrial cancer (EC) survivors. A systematic literature review was conducted in July 2021 to identify studies detailing the effect size for the relationship between HT use in EC and oncological outcomes (survival and disease recurrence). This included studies that evaluated the different recurrence rates among women treated for EC who subsequently underwent HT and those who did not. The collected studies were evaluated for quality, heterogeneity, and publication bias, and a pooled odds ratio (OR) or hazard ratio (HR) was calculated with a confidence interval of 95% (95% CI). In total, 5291 studies were collated, and after the review process, one randomized trial and seven observational studies were included, comprising 1801 EC survivors treated with HT and 6015 controls. The time-dependent analysis could be conducted for four studies, and considering the disease-free survival, the pooled HR of 0.90 (95% CI 0.28 to 2.87) showed no significant differences. However, among Black American women treated with continuous estrogen HT, the HR was 7.58 (95% CI 1.96 to 29.31), showing a significantly increased risk of recurrence for women in this ethnic group. Considering the pooled OR of all included studies 0.63 (95% CI 0.48 to 0.83), a significantly reduced risk of recurrence was found among EC survivors treated with HT. Considering the type of HT, the most risk-reducing was combined estrogen and progestin therapy and the cyclic regimen. Although supporting evidence is based mainly upon observational studies, evidence of no increased risk or even decreased risk was generally found, apart from in Black American women where a significantly increased recurrence risk was evident. The data are rather reassuring for the short-term administration of HT to symptomatic EC survivors. Future studies with a longer follow-up are necessary to better clarify the long-term effects of HT.

scholarly journals Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness

2020 ◽  
Author(s):  
Sharon K Hunter ◽  
M Camille Hoffman ◽  
Lizbeth McCarthy ◽  
Angelo D’Alessandro ◽  
Anna Wyrwa ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Black Americans ◽  
Mental Illnesses ◽  
Black American ◽  
American Women ◽  
Black American Women ◽  
Increased Risk ◽  
Gestational Age At Birth ◽  
Age At Birth

Abstract Black Americans have increased risk for schizophrenia and other mental illnesses with prenatal origins. Prenatal choline promotes infant brain development and behavioral outcomes, but choline has not been specifically assessed in Black Americans. Pregnant women (N = 183, N = 25 Black Americans) enrolled in a study of prenatal stressors and interactions with prenatal choline. Black American women had lower 16-week gestation plasma choline than Whites. Lower choline was not related to obesity, income, or metabolic genotypes. Pregnant women in rural Uganda have higher choline levels than Black American women. Black Americans’ lower choline was associated with higher hair cortisol, indicative of higher stress. Lower maternal choline was associated with offsprings’ lower gestational age at birth and with decreased auditory P50 inhibition, a marker of inhibitory neuron development. Behavioral development was assessed on the Infant Behavior Questionnaire-R-SF (IBQ-R) at 3 months. Lower Black American maternal gestational choline was associated with lower infant IBQ-R Orienting/Regulation, indicating decreased attention and relation to caregivers. Additional evidence for developmental effects of choline in Black Americans comes from a randomized clinical trial of gestational phosphatidylcholine supplementation versus placebo that included 15 Black Americans. Phosphatidylcholine increased gestational age at birth and newborn P50 inhibition and decreased Social Withdrawn and Attention problems at 40 months of age in Black Americans’ offspring compared to placebo. Inhibitory and behavioral deficits associated with lower prenatal choline in offspring of Black American women indicate potential developmental predispositions to later mental illnesses that might be ameliorated by prenatal choline or phosphatidylcholine supplementation.

Black Beauty: Womanist Consciousness as a Protective Factor in Black Women’s Body Image Satisfaction

2021 ◽  
pp. 009579842110349
Author(s):  
Speshál Walker Gautier
Keyword(s):  
Body Image ◽  
Ethnic Identity ◽  
Body Satisfaction ◽  
Protective Factor ◽  
Skin Tone ◽  
Black American ◽  
Body Type ◽  
Body Image Satisfaction ◽  
American Women ◽  
Black American Women

Black American women are exposed to mainstream beauty standards, which may have implications for body image satisfaction. Given that beauty standards are often based on idealized depictions of White women’s physical features, scholars have called for body image research that extends beyond body type/weight (e.g., skin tone/hair) to better examine the experiences of Black women. In examining body image satisfaction and protective factors (e.g., ethnic identity), empirical research has yet to attend to these experiences at the intersection of race/ethnicity and gender. The current study used an online survey to examine whether womanist consciousness (WC) was a protective factor for Black American women ( N = 211). Findings indicated that after controlling for ethnic identity, higher womanist consciousness significantly predicted higher body satisfaction with historically racially defined features (e.g., skin tone/hair) and lower self-ideal discrepancy. Darker skin tone was linked to higher body importance and higher ethnic identity level. Last, increased frequency of wearing hair weaves was associated with lower body satisfaction while more frequently wearing Afrocentric hair styles/textures was associated with higher body satisfaction.

African American Women, Racism and Triple Oppression

2020 ◽  
Vol 1 (1) ◽  
pp. 113-117
Author(s):  
Rajendra Prasad Chapagain
Keyword(s):  
African American ◽  
African American Women ◽  
Racial Discrimination ◽  
Black Men ◽  
Black Males ◽  
White Women ◽  
Black American ◽  
American Women ◽  
Black American Women ◽  
Sexual Repression

African American women have been made multiple victims: racial discrimination by the white community and sexual repression by black males of their own community. They have been subjected to both kind of discrimination - racism and sexism. It is common experience of black American women. Black American women do have their own peculiar world and experiences unlike any white or black men and white women. They have to fight not only against white patriarchy and white women's racism but also against sexism of black men within their own race. To be black and female is to suffer from the triple oppression- sexism, racism and classicism.

scholarly journals Increased Risk of Recurrence After Hormone Replacement Therapy in Breast Cancer Survivors

2008 ◽  
Vol 100 (7) ◽  
pp. 475-482 ◽  
Author(s):  
L. Holmberg ◽  
O.-E. Iversen ◽  
C. M. Rudenstam ◽  
M. Hammar ◽  
E. Kumpulainen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Replacement Therapy ◽  
Cancer Survivors ◽  
Replacement Therapy ◽  
Breast Cancer Survivors ◽  
Hormone Replacement ◽  
Risk Of Recurrence ◽  
Increased Risk

Association between hormone replacement therapy and dementia: is it time to forget?

2005 ◽  
Vol 17 (2) ◽  
pp. 155-164 ◽  
Author(s):  
Osvaldo P. Almeida ◽  
Leon Flicker
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Observational Studies ◽  
Animal Studies ◽  
Hormone Replacement ◽  
Health Events ◽  
Increased Risk ◽  
Estrogen Plus Progestin ◽  
History Of

The results of in vitro and animal studies provide a strong rationale for the use of hormone replacement therapy (HRT) to prevent dementia and Alzheimer's disease (AD). In humans, the results of 16 observational studies are consistent with the hypothesis that estrogen use reduces the risk of AD by 10 to 60%. However, women who are prescribed HRT are less likely to have hypertension, diabetes and history of stroke than nonusers. As all of these factors have been associated with increased risk of dementia (including AD), this “prescription bias” may have a significant impact on the results of observational studies. Randomized trials are designed with the aim of avoiding many of the potential biases and confounding (measured or unmeasured) of observational studies. The results of the Women's Health Initiative Memory Study (WHIMS) indicate that HRT (estrogen plus progestin or estrogen alone) increases the risk of dementia (hazard ratio, HR=1.8, 95% CI=1.2–2.6). Taking into account the results of the WHIMS and the adverse health events associated with the use of estrogen plus progestin or estrogen alone, we conclude that HRT cannot be recommended as a safe and effective strategy to prevent dementia.

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