scholarly journals HBV and HDV: New Treatments on the Horizon

2021 ◽  
Vol 10 (18) ◽  
pp. 4054
Author(s):  
Valentina Zuccaro ◽  
Erika Asperges ◽  
Marta Colaneri ◽  
Lea Nadia Marvulli ◽  
Raffaele Bruno
Keyword(s):  
Chronic Hepatitis ◽  
Special Populations ◽  
Functional Cure ◽  
Critical Issues ◽  
Investigational Therapies ◽  
Drug Actions ◽  
Hdv Infection ◽  
New Treatments ◽  
Global Health Problem

Despite the accumulating knowledge, chronic hepatitis B (CHB) and HDV infection represent a global health problem, and there are still several critical issues, which frequently remain uncovered. In this paper, we provided an overview of the current therapeutic options and summarized the investigational therapies in the pipeline. Furthermore, we discussed some critical issues such as a “functional cure” approach, the futility of long-term NA therapy and the relevance of understanding drug actions and safety of antivirals, especially in special populations.

Durable virological response and functional cure of chronic hepatitis D after long‐term peginterferon therapy

2021 ◽  
Author(s):  
Julian Hercun ◽  
Grace E. Kim ◽  
Ben L. Da ◽  
Yaron Rotman ◽  
David E. Kleiner ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Virological Response ◽  
Functional Cure ◽  
Hepatitis D

Combinatorial RNAi/vaccination therapy for chronic hepatitis B achieves long-term functional cure in preclinical mouse model

2018 ◽  
Vol 68 ◽  
pp. S16 ◽  
Author(s):  
T. Michler ◽  
A. Kosinska ◽  
T. Bunse ◽  
M. Heikenwälder ◽  
D. Grimm ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Mouse Model ◽  
Chronic Hepatitis B ◽  
Functional Cure ◽  
Vaccination Therapy

scholarly journals RAGAMAN GENETIK GEN POLIMERASE VIRUS HEPATITIS B PADA PASIEN HEPATITIS B KRONIK DENGAN PENGOBATAN TELBIVUDIN

2018 ◽  
Vol 21 (2) ◽  
pp. 138
Author(s):  
Gondo Mastutik ◽  
Juniastuti Juniastuti ◽  
Ali Rohman ◽  
Mochamad Amin ◽  
Poernomo Boedi Setiawan
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Point Mutations ◽  
Virus Hepatitis ◽  
Polymerase Gene ◽  
Mutation Profile ◽  
B Virus ◽  
Global Health Problem

Infection caused by hepatitis B virus (HBV) is still a major global health problem and can cause liver cirrhosis and hepatocellularcarcinoma as well. Telbivudine is one among the drugs used to treat the disease routinely. However, using this drug in a long term therapymight cause mutations in HBV polymerase gene that decreases the effectiveness of the therapy. Here with the researchers report the geneticvariations of the gene isolated from telbivudine-which is used treated chronic hepatitis B patients in Surabaya, Indonesia. The blood serawere collected at Dr. Soetomo hospital from 10 telbivudine-treated and 10 untreated chronic hepatitis B patients. The DNA viral wasisolated and purified from each serum. Sequence polymerase gene at nucleotides 455 to 796 was amplified by PCR, and then analyzedbio informatically to determine their mutation profile. This study revealed a point mutation in HBV25 sample at nucleotide A1525G thatgives rise to I509V modification. Such mutation is also observed in a sequence that is available in Gen Bank with an accession numberAY641562. Additionally, the researchers found point mutations A1554G, T1593C, and C1629T in HBV25 sample and a point mutationA1554G in HBV20 sample. However, these mutations are silent. To conclude, the mutation in HBV polymerase gene among telbivudinetreatedchronic hepatitis B patients in Surabaya is known as A1525G.

Absence of long term relapse in patients with a good virological response at 5 months after treatment for chronic hepatitis C

2001 ◽  
Vol 120 (5) ◽  
pp. A380-A380
Author(s):  
P PONSODAJR ◽  
P BLANCSR ◽  
G PHILIPPEPAGEAUXSR ◽  
J RAMOSSR ◽  
J DUCOSSR ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Virological Response
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