scholarly journals The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease

2021 ◽  
Vol 10 (18) ◽  
pp. 4055
Author(s):  
Magdalena Stojek ◽  
Anna Jabłońska ◽  
Krystian Adrych

The exact pathogenesis of inflammatory bowel disease (IBD) is still not completely understood. It is hypothesized that a genetic predisposition leads to an exaggerated immune response to an environmental trigger, leading to uncontrolled inflammation. As there is no known causative treatment, current management strategies for inflammatory bowel disease focus on correcting the excessive immune response to environmental (including microbial) triggers. In recent years, there has been growing interest in new avenues of treatment, including targeting the microbial environment itself. Fecal microbiota transplantation (FMT) is a novel treatment modality showing promising results in early studies. The article discusses the rationale for the use of FMT in inflammatory bowel disease and the yet-unresolved questions surrounding its optimal use in practice.

2019 ◽  
Vol 12 ◽  
pp. 175628481983689 ◽  
Author(s):  
Alexander N. Levy ◽  
Jessica R. Allegretti

Fecal microbiota transplantation (FMT) has changed the treatment landscape of Clostridium difficile infection (CDI). Emerging evidence has shown that FMT can also be an effective and safe treatment strategy in CDI with underlying inflammatory bowel disease (IBD). Recently, randomized controlled trials of FMT in ulcerative colitis support its expanding role in restoring gut homeostasis in this disease. However, heterogeneous study designs leave several questions yet to be answered, including how to best position this novel therapy in the treatment approach of Crohn’s disease and pouchitis. Additional studies are needed to validate whether FMT can assume a complementary role in the standard treatment of IBD.


2018 ◽  
Vol 19 (6) ◽  
pp. 322-334 ◽  
Author(s):  
Irene D'Odorico ◽  
Stefano Di Bella ◽  
Jacopo Monticelli ◽  
Daniele R Giacobbe ◽  
Emma Boldock ◽  
...  

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