scholarly journals The Role of Neuropeptides in Pathogenesis of Dry Dye

2021 ◽  
Vol 10 (18) ◽  
pp. 4248
Author(s):  
Daniel Duck-Jin Hwang ◽  
Seok-Jae Lee ◽  
Jeong-Hun Kim ◽  
Sang-Mok Lee
Keyword(s):  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Future Research ◽  
Immune Systems ◽  
Pathogenic Mechanisms ◽  
Corneal Nerves ◽  
Ocular Surface Diseases ◽  
Corneal Nerve

Neuropeptides are known as important mediators between the nervous and immune systems. Recently, the role of the corneal nerve in the pathogenesis of various ocular surface diseases, including dry eye disease, has been highlighted. Neuropeptides are thought to be important factors in the pathogenesis of dry eye disease, as suggested by the well-known role between the nervous and immune systems, and several recently published studies have elucidated the previously unknown pathogenic mechanisms involved in the role of the neuropeptides secreted from the corneal nerves in dry eye disease. Here, we reviewed the emerging concept of neurogenic inflammation as one of the pathogenic mechanisms of dry eye disease, the recent results of related studies, and the direction of future research.

scholarly journals The immunoregulatory role of corneal epithelium-derived thrombospondin-1 in dry eye disease

2018 ◽  
Vol 16 (4) ◽  
pp. 470-477 ◽  
Author(s):  
Xuhua Tan ◽  
Yihe Chen ◽  
William Foulsham ◽  
Afsaneh Amouzegar ◽  
Takenori Inomata ◽  
...  
Keyword(s):  
Dry Eye ◽  
Corneal Epithelium ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Thrombospondin 1

The Role of Oxidative Stress and Inflammation in Dry Eye Disease

Cornea ◽  
2009 ◽  
Vol 28 (Suppl 1) ◽  
pp. S70-S74 ◽  
Author(s):  
Murat Dogru ◽  
Tais Wakamatsu ◽  
Takashi Kojima ◽  
Yukihiro Matsumoto ◽  
Tetsuya Kawakita ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease

scholarly journals Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Thomas John ◽  
Sean Tighe ◽  
Hosam Sheha ◽  
Pedram Hamrah ◽  
Zeina M. Salem ◽  
...  
Keyword(s):  
Nerve Regeneration ◽  
Dry Eye ◽  
Amniotic Membrane ◽  
Signs And Symptoms ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Study Group ◽  
Corneal Sensitivity ◽  
Corneal Nerve

Purpose. To evaluate the efficacy of self-retained cryopreserved amniotic membrane (CAM) in promoting corneal nerve regeneration and improving corneal sensitivity in dry eye disease (DED).Methods. In this prospective randomized clinical trial, subjects with DED were randomized to receive CAM (study group) or conventional maximum treatment (control). Changes in signs and symptoms, corneal sensitivity, topography, and in vivo confocal microscopy (IVCM) were evaluated at baseline, 1 month, and 3 months.Results. Twenty subjects (age 66.9 ± 8.9) were enrolled and 17 completed all follow-up visits. Signs and symptoms were significantly improved in the study group yet remained constant in the control. IVCM showed a significant increase in corneal nerve density in the study group (12,241 ± 5083 μm/mm2at baseline, 16,364 ± 3734 μm/mm2at 1 month, and 18,827 ± 5453 μm/mm2at 3 months,p=0.015) but was unchanged in the control. This improvement was accompanied with a significant increase in corneal sensitivity (3.25 ± 0.6 cm at baseline, 5.2 ± 0.5 cm at 1 month, and 5.6 ± 0.4 cm at 3 months,p<0.001) and corneal topography only in the study group.Conclusions. Self-retained CAM is a promising therapy for corneal nerve regeneration and accelerated recovery of the ocular surface health in patients with DED. The study is registered at clinicaltrials.gov with trial identifier:NCT02764814.

scholarly journals Tear Film – Physiology and Disturbances in Various Diseases and Disorders

2021 ◽  
Author(s):  
Dorota Kopacz ◽  
Łucja Niezgoda ◽  
Ewa Fudalej ◽  
Anna Nowak ◽  
Piotr Maciejewicz
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Fluid Layer ◽  
Dynamic Balance ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Immune Protection ◽  
Topical Medications

The tear film is a thin fluid layer covering the ocular surface. It is responsible for ocular surface comfort, mechanical, environmental and immune protection, epithelial health and it forms smooth refractive surface for vision. The traditional description of the tear film divides it into three layers: lipid, aqueous and mucin. The role of each layer depends on the composition of it. Tear production, evaporation, absorption and drainage concur to dynamic balance of the tear film and leads to its integrity and stability. Nonetheless, this stability can be disturb in tear film layers deficiencies, defective spreading of the tear film, in some general diseases and during application of some general and/or topical medications. Dry eye disease is the result of it. In this review not only physiology of the tear film is presented. Moreover, we would like to discuss the influence of various diseases and conditions on the tear film and contrarily, spotlight tear film disorders as a manifestation of those diseases.

scholarly journals Omega-3 supplementation is neuroprotective to corneal nerves in dry eye disease: a pilot study

2017 ◽  
Vol 37 (4) ◽  
pp. 473-481 ◽  
Author(s):  
Holly R. Chinnery ◽  
Cecilia Naranjo Golborne ◽  
Laura E. Downie
Keyword(s):  
Pilot Study ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Omega 3 ◽  
Corneal Nerves

scholarly journals A cross-sectional study of ocular surface discomfort and corneal nerve dysfunction after paclitaxel treatment for cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jeremy Chung Bo Chiang ◽  
David Goldstein ◽  
Terry Trinh ◽  
Kimberley Au ◽  
Susanna B. Park ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Dry Eye ◽  
Ocular Surface ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Peripheral Neurotoxicity ◽  
Patient Reported ◽  
Paclitaxel Group ◽  
Corneal Nerve ◽  
Paclitaxel Treatment

AbstractOcular surface dysfunction is common in patients receiving anti-cancer drug treatment. The effects of paclitaxel, a neurotoxic chemotherapeutic drug, on ocular surface discomfort associated with dry eye disease was investigated. Patients with cancer who had completed paclitaxel treatment between 3 and 24 months prior to assessment (n = 29) and age- and sex-matched healthy control subjects (n = 29) were recruited and assessed with the Ocular Surface Disease Index (OSDI) to measure ocular surface discomfort. In-vivo corneal confocal microscopy was used to evaluate corneal nerve parameters in the right eye. Peripheral neurotoxicity was assessed using patient-reported outcomes and clinical grading scales. The paclitaxel group had significantly worse OSDI total scores compared with controls (Median, Md = 19.3 and Md = 0, p = 0.007, respectively). Corneal nerve fiber and inferior whorl lengths were reduced in the paclitaxel group compared with controls (14.2 ± 4.0 and 14.4 ± 4.0 mm/mm2 vs. 16.4 ± 4.0 and 16.9 ± 4.9 mm/mm2, respectively, p = 0.04). When analyzed by presence of peripheral neuropathy, paclitaxel-treated patients with neuropathy showed worse OSDI total scores compared to those without peripheral neuropathy post-treatment (p = 0.001) and healthy controls (p < 0.001). More severe ocular discomfort and worse visual function was associated with greater peripheral neurotoxicity symptoms (r = 0.60, p = 0.001) and neuropathy severity (r = 0.49, p = 0.008), respectively. Patients who have been treated with paclitaxel have a higher risk of ocular surface discomfort associated with dry eye disease, particularly those with peripheral neuropathy. Future longitudinal studies should investigate the clinical impact of corneal nerve reduction in dry eye disease.

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