scholarly journals Transcutaneous Spinal Cord Stimulation Enhances Quadriceps Motor Evoked Potential in Healthy Participants: A Double-Blind Randomized Controlled Study

2020 ◽  
Vol 9 (10) ◽  
pp. 3275
Author(s):  
Álvaro Megía-García ◽  
Diego Serrano-Muñoz ◽  
Julian Taylor ◽  
Juan Avendaño-Coy ◽  
Natalia Comino-Suárez ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
Motor Evoked Potentials ◽  
Motor Evoked Potential ◽  
Controlled Study ◽  
Invasive Technique ◽  
Vertebral Level ◽  
Double Blind ◽  
Cord Injury ◽  
Healthy Participants

Transcutaneous electrical spinal cord stimulation (tSCS) is a non-invasive technique for neuromodulation and has therapeutic potential for motor rehabilitation following spinal cord injury. The main aim of the present study is to quantify the effect of a single session of tSCS on lower limb motor evoked potentials (MEPs) in healthy participants. A double-blind, sham-controlled, randomized, crossover, clinical trial was carried out in 15 participants. Two 10-min sessions of tSCS (active-tSCS and sham-tSCS) were applied at the T11-T12 vertebral level. Quadriceps (Q) and tibialis anterior (TA) muscle MEPs were recorded at baseline, during and after tSCS. Q and TA isometric maximal voluntary contraction was also recorded. A significant increase of the Q-MEP amplitude was observed during active-tSCS (1.96 ± 0.3 mV) when compared from baseline (1.40 ± 0.2 mV; p = 0.01) and when compared to sham-tSCS at the same time-point (1.13 ± 0.3 mV; p = 0.03). No significant modulation was identified for TA-MEP amplitude or for Q and TA isometric maximal voluntary isometric strength. In conclusion, tSCS applied over the T11-T12 vertebral level increased Q-MEP but not TA-MEP compared to sham stimulation. The specific neuromodulatory effect of tSCS on Q-MEP may reflect optimal excitation of this motor response at the interneuronal or motoneuronal level.

scholarly journals Alendronate Prevents Bone Loss in Patients with Acute Spinal Cord Injury: A Randomized, Double-Blind, Placebo-Controlled Study

2007 ◽  
Vol 92 (4) ◽  
pp. 1385-1390 ◽  
Author(s):  
N. L. Gilchrist ◽  
C. M. Frampton ◽  
R. H. Acland ◽  
M. G. Nicholls ◽  
R. L. March ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Loss ◽  
Acute Spinal Cord Injury ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Cord Injury

Motor Evoked Potentials Elicited from Pyramidal Stimulation and Recorded from the Spinal Cord in the Rat

Neurosurgery ◽  
1991 ◽  
Vol 28 (4) ◽  
pp. 550-558 ◽  
Author(s):  
John Ryder ◽  
Rosario Zappulla ◽  
Julia Nieves
Keyword(s):  
Spinal Cord ◽  
Electrical Stimulation ◽  
Sensorimotor Cortex ◽  
Pyramidal Tract ◽  
Motor Evoked Potentials ◽  
Motor Evoked Potential ◽  
Evoked Response ◽  
Cord Injury ◽  
Latency Response ◽  
Stimulation Of

Abstract This study investigated the spinal evoked response to focal electrical stimulation of the sensorimotor cortex in 32 rats. The results demonstrate a long-latency response (beginning at 8 milliseconds); elicited by electrical stimulation, which is distinct from the short-latency motor evoked potential previously reported. The conduction velocity of this later response is similar to that reported for the pyramidal tract in the rat. Experiments confirm that the longer latency response depends upon the integrity of the pyramidal system. Focal stimulation outside the sensorimotor cortex failed to elicit a response. Experimental lesions of the pyramidal tract or ablating the sensorimotor cortex eliminated the spinal cord evoked response. The results demonstrate that focal stimulation of the sensorimotor cortex results in a spinal cord evoked response that represents activity within the pyramidal system. The utility of this response in the rat model for assessing experimental cord injury is discussed.

Analgesic Efficacy of High-Frequency Spinal Cord Stimulation: A Randomized Double-Blind Placebo-Controlled Study

2013 ◽  
Vol 16 (4) ◽  
pp. 363-369 ◽  
Author(s):  
Christophe Perruchoud ◽  
Sam Eldabe ◽  
Alan M. Batterham ◽  
Grace Madzinga ◽  
Morag Brookes ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Stimulation ◽  
High Frequency ◽  
Analgesic Efficacy ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Effects of progesterone and vitamin D on outcome of patients with acute traumatic spinal cord injury; a randomized, double-blind, placebo controlled study

2015 ◽  
Vol 39 (3) ◽  
pp. 272-280 ◽  
Author(s):  
Bahram Aminmansour ◽  
Ali Asnaashari ◽  
Majid Rezvani ◽  
Fariborz Ghaffarpasand ◽  
Seyed Mohammad Amin Noorian ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Vitamin D ◽  
Spinal Cord Injury ◽  
Controlled Study ◽  
Traumatic Spinal Cord Injury ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Cord Injury

Magnetic motor evoked potential monitoring in the rat

1999 ◽  
Vol 91 (2) ◽  
pp. 205-210 ◽  
Author(s):  
R. Dean Linden ◽  
Yi-Ping Zhang ◽  
Darlene A. Burke ◽  
Matthew A. Hunt ◽  
John E. Harpring ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Evoked Potentials ◽  
Stimulus Intensity ◽  
Magnetic Stimulation ◽  
Motor Evoked Potentials ◽  
Motor Evoked Potential ◽  
Onset Latency ◽  
Content Type ◽  
Cord Injury ◽  
Fine Print

Object. The authors conducted a study to provide an objective electrophysiological assessment of descending motor pathways in rats, which may become a means for predicting outcome in spinal cord injury research. Methods. Transcranial magnetic motor evoked potentials (TMMEPs) were recorded under various conditions in awake, nonanesthetized, restrained rats. Normative data were collected to determine the reproducibility of the model and to evaluate the effect of changing the stimulus intensity on the evoked signals. In addition, an experiment was performed to determine if the TMMEPs produced were the result of auditory startle response (ASR) potentials elicited by the sound generated by the movement of the copper coil inside its casing during magnetic stimulation. Transcranial magnetic motor evoked potentials were elicited after magnetic stimulation. At 100% stimulus intensity, the mean forelimb onset latency was 4.2 ± 0.39 msec, and the amplitude was 9.16 ± 3.44 mV. The hindlimb onset latency was 6.5 ± 0.47 msec, and the amplitude was 11.47 ± 5.25 mV. As the stimulus intensity was decreased, the TMMEP onset latency increased and the response amplitude decreased. The ASR potentials were shown to have longer latencies, smaller amplitudes, and were more variable than those of the TMMEPs. Conclusions. These experiments demonstrate that TMMEPs can be recorded in awake, nonanesthetized rats. The evoked signals were easy to elicit and reproduce. This paper introduces noninvasive TMMEPs as a new technique for monitoring the physiological integrity of the rat spinal cord.

scholarly journals Reduction of spinal sensory transmission by facilitation of 5-HT1B/D receptors in noninjured and spinal cord-injured humans

2013 ◽  
Vol 109 (6) ◽  
pp. 1485-1493 ◽  
Author(s):  
Jessica M. D'Amico ◽  
Yaqing Li ◽  
David J. Bennett ◽  
Monica A. Gorassini
Keyword(s):  
Spinal Cord ◽  
H Reflex ◽  
Controlled Study ◽  
Double Blind ◽  
Afferent Pathways ◽  
Persistent Inward Currents ◽  
Sensory Transmission ◽  
Cord Injury ◽  
Inward Currents ◽  
Spinal Cord Injured

Activation of receptors by serotonin (5-HT1) and norepinephrine (α2) on primary afferent terminals and excitatory interneurons reduces transmission in spinal sensory pathways. Loss or reduction of descending sources of serotonin and norepinephrine after spinal cord injury (SCI) and the subsequent reduction of 5-HT1/α2 receptor activity contributes, in part, to the emergence of excessive motoneuron activation from sensory afferent pathways and the uncontrolled triggering of persistent inward currents that depolarize motoneurons during muscle spasms. We tested in a double-blind, placebo-controlled study whether facilitating 5-HT1B/D receptors with the agonist zolmitriptan reduces the sensory activation of motoneurons during an H-reflex in both noninjured control and spinal cord-injured participants. In both groups zolmitriptan, but not placebo, reduced the size of the maximum soleus H-reflex with a peak decrease to 59% (noninjured) and 62% (SCI) of predrug values. In SCI participants we also examined the effects of zolmitriptan on the cutaneomuscular reflex evoked in tibialis anterior from stimulation to the medial arch of the foot. Zolmitriptan, but not placebo, reduced the long-latency, polysynaptic component of the cutaneomuscular reflex (first 200 ms of reflex) by ∼50%. This ultimately reduced the triggering of the long-lasting component of the reflex (500 ms poststimulation to end of reflex) known to be mediated by persistent inward currents in the motoneuron. These results demonstrate that facilitation of 5-HT1B/D receptors reduces sensory transmission in both monosynaptic and polysynaptic reflex pathways to ultimately reduce long-lasting reflexes (spasms) after SCI.

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