scholarly journals The Future of Origin of Life Research: Bridging Decades-Old Divisions

Life ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 20 ◽  
Author(s):  
Martina Preiner ◽  
Silke Asche ◽  
Sidney Becker ◽  
Holly C. Betts ◽  
Adrien Boniface ◽  
...  
Keyword(s):  
Origin Of Life ◽  
Historical Development ◽  
Rna World ◽  
Early Career ◽  
Top Down ◽  
Early Career Researchers ◽  
The Future ◽  
Recent Developments ◽  
Divergence Points ◽  
The Origin Of Life

Research on the origin of life is highly heterogeneous. After a peculiar historical development, it still includes strongly opposed views which potentially hinder progress. In the 1st Interdisciplinary Origin of Life Meeting, early-career researchers gathered to explore the commonalities between theories and approaches, critical divergence points, and expectations for the future. We find that even though classical approaches and theories—e.g., bottom-up and top-down, RNA world vs. metabolism-first—have been prevalent in origin of life research, they are ceasing to be mutually exclusive and they can and should feed integrating approaches. Here we focus on pressing questions and recent developments that bridge the classical disciplines and approaches, and highlight expectations for future endeavours in origin of life research.

scholarly journals Are Scientific Models of Life Testable? A Lesson from Simpson’s Paradox

Sci ◽  
2020 ◽  
Vol 2 (3) ◽  
pp. 73
Author(s):  
Prasanta S. Bandyopadhyay ◽  
Nolan Grunska ◽  
Don Dcruz ◽  
Mark C. Greenwood
Keyword(s):  
Origin Of Life ◽  
Rna World ◽  
Scientific Models ◽  
Scientific Model ◽  
Simpson’S Paradox ◽  
World Theory ◽  
Life Issues ◽  
The Origin Of Life ◽  
Logical Sense ◽  
Simpson's Paradox

We address the need for a model by considering two competing theories regarding the origin of life: (i) the Metabolism First theory and (ii) the RNA World theory. We discuss two inter-related points. (I) Models are valuable tools in understanding both the processes and intricacies of the origin of life issues. (II) Insights from models also help us to evaluate the core objection to origin of life theories called “the inefficiency objection” commonly raised by proponents of both the Metabolism First theory and the RNA World theory against each other. We use Simpson’s paradox as a tool for challenging this objection. We will use models in various senses ranging from taking them as representations of reality to treating them as theories/accounts that provide heuristics for probing reality. In this paper, we will frequently use models and theories interchangeably. Additionally, we investigate Conway’s Game of Life and contrast it with our Simpson’s Paradox (SP)-based approach to emergence of life issues. Finally, we discuss some of the consequences of our view. A scientific model is testable in three senses: (i) a logical sense, (ii) a nomological sense, and (iii) a current technological sense. The SP-based model is testable in the logical sense. It is also testable nomologically. However, it is not currently feasible to test it.

scholarly journals ‘Whole Organism’, Systems Biology, and Top-Down Criteria for Evaluating Scenarios for the Origin of Life

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 690
Author(s):  
Clifford F. Brunk ◽  
Charles R. Marshall
Keyword(s):  
Origin Of Life ◽  
Top Down ◽  
Chemical Systems ◽  
Biochemical Pathways ◽  
The Origin Of Life ◽  
Energy And Material Flows ◽  
Complex Scenario ◽  
Life On Earth ◽  
Physical Laws ◽  
Equilibrium Chemical

While most advances in the study of the origin of life on Earth (OoLoE) are piecemeal, tested against the laws of chemistry and physics, ultimately the goal is to develop an overall scenario for life’s origin(s). However, the dimensionality of non-equilibrium chemical systems, from the range of possible boundary conditions and chemical interactions, renders the application of chemical and physical laws difficult. Here we outline a set of simple criteria for evaluating OoLoE scenarios. These include the need for containment, steady energy and material flows, and structured spatial heterogeneity from the outset. The Principle of Continuity, the fact that all life today was derived from first life, suggests favoring scenarios with fewer non-analog (not seen in life today) to analog (seen in life today) transitions in the inferred first biochemical pathways. Top-down data also indicate that a complex metabolism predated ribozymes and enzymes, and that full cellular autonomy and motility occurred post-LUCA. Using these criteria, we find the alkaline hydrothermal vent microchamber complex scenario with a late evolving exploitation of the natural occurring pH (or Na+ gradient) by ATP synthase the most compelling. However, there are as yet so many unknowns, we also advocate for the continued development of as many plausible scenarios as possible.

Condensation Reactions Synthesize Random Polymers

2019 ◽  
Author(s):  
David Ross
Keyword(s):  
Origin Of Life ◽  
Rna World ◽  
Functional Polymers ◽  
Peptide Bonds ◽  
Individual Molecular Species ◽  
Condensation Reactions ◽  
Past Half Century ◽  
Working Together ◽  
The Origin Of Life ◽  
The Individual

Over the past half century of serious research on the origin of life, several schools of thought have emerged that focus on “worlds” and what came first in the pathway to the origin of life. One example is the RNA World, a term coined by Walter Gilbert after the discovery of ribozymes. Other examples include the Iron-Sulfur World of Günther Wächtershäuser and the Lipid World proposed by Doron Lancet and coworkers. Then we have a competition between “metabolism first” and “replication first” schools. The worlds and schools have the positive effect of sharpening arguments and forcing us to think carefully, but they also can lock researchers into defending their individual approaches rather than looking for patterns in a larger perspective. One of the main themes of this book is the notion that the first living cells were systems of functional polymers working together within membranous compartments. Therefore, it is best not to think of “worlds” and “firsts” as fundamentals but instead as components evolving together toward the assembly of an encapsulated system of functional polymers. At first the polymers will be composed of random sequences of their monomers, and the compartments will contain random assortments of polymers. Here, we refer to these structures as protocells which are being produced in vast numbers as they form and decompose in continuous cycles driven by a variety of impinging, free-energy sources. This chapter describes how thermodynamic principles can be used to test the feasibility of a proposed mechanism by which random polymers can be synthesized. There is a current consensus that early life may have passed through a phase in which RNA served as a ribozyme catalyst, as a replicating system, and as a means for storing and expressing genetic information. For this reason, we will use RNA as a model polymer, but condensation reactions also produce peptide bonds and oligopeptides. At some point in the evolutionary steps leading to life, peptides and RNA formed complexes with novel functional properties beyond those of the individual molecular species.

scholarly journals Support of Early-Career Researchers Supports the Future of ASLO

2019 ◽  
Vol 28 (1) ◽  
pp. 34-34
Author(s):  
Kaitlin J. Farrell ◽  
Alli N. Cramer ◽  
Kelly L. Hondula ◽  
Seth K. Thompson ◽  
Jacob A. Zwart
Keyword(s):  
Early Career ◽  
Early Career Researchers ◽  
The Future

scholarly journals Dispositives of newness and change: academic organisations’ discursive practice at the intersection of excellence and gender

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Sarah Wieners ◽  
Susanne Maria Weber
Keyword(s):  
Discourse Analysis ◽  
Gender Equality ◽  
Early Career ◽  
Discursive Practice ◽  
Top Down ◽  
Common Features ◽  
Early Career Researchers ◽  
Excellence Initiative ◽  
Institutional Innovations ◽  
And Gender

AbstractOn the basis of a genealogical discourse analysis, Weber distinguishes four dispositives of creation. The ‘new’ is created and organised within systematic rationalities of creation. It emerges in (a) an organic cyclical transcendence, (b) a top-down pattern, (c) an entrepreneurial mode that designates man as creator and (d) a collective cyclical dynamic. The dispositives of man as creator and creation as an act are becoming particularly dominant in today’s academic organisations and these dispositives systematically produce institutional programmatics and organisational strategies. In this paper, we analyse how the new emerges in two academic organisations. The starting points of our analyses are two institutional innovations that emerged in Germany in the 2000s: the Excellence Initiative and the gender equality programme. Although they derive from different fields of discourse, both innovations share common features. The Excellence Initiative required universities to relate discourses of excellence and gender equality to each other, and this article investigates how the new emerges in academic organisations to understand whether these innovations produce equality or perpetuate traditional inequalities. Based on Foucault’s dispositive methodology, we use website analyses and interviews with gender equality officers and heads of early-career researchers’ departments. We highlight the discursive connections between gender and excellence for early-career researchers and outline various discursive organisational strategies.

Early Career Researchers and Mentors Work Together to Shape the Future of the Arctic Monitoring and Assessment Programme

ARCTIC ◽  
2012 ◽  
Vol 65 (1) ◽  
Author(s):  
J.F. Provencher ◽  
N. Gantner ◽  
J. Schmale ◽  
H. Swanson ◽  
J.L. Baeseman
Keyword(s):  
Early Career ◽  
The Arctic ◽  
Assessment Programme ◽  
Early Career Researchers ◽  
The Future

Understanding Life: A Bioinformatics Perspective

2016 ◽  
Vol 25 (2) ◽  
pp. 231-245 ◽  
Author(s):  
Natalia Szostak ◽  
Szymon Wasik ◽  
Jacek Blazewicz
Keyword(s):  
Origin Of Life ◽  
Rna World ◽  
Origins Of Life ◽  
Life Itself ◽  
Wet Lab ◽  
The Origin Of Life ◽  
To Come ◽  
World Hypothesis ◽  
Definition Of ◽  
Rna World Hypothesis

According to some hypotheses, from a statistical perspective the origin of life seems to be a highly improbable event. Although there is no rigid definition of life itself, life as it is, is a fact. One of the most recognized hypotheses for the origins of life is the RNA world hypothesis. Laboratory experiments have been conducted to prove some assumptions of the RNA world hypothesis. However, despite some success in the ‘wet-lab’, we are still far from a complete explanation. Bioinformatics, supported by biomathematics, appears to provide the perfect tools to model and test various scenarios of the origins of life where wet-lab experiments cannot reflect the true complexity of the problem. Bioinformatics simulations of early pre-living systems may give us clues to the mechanisms of evolution. Whether or not this approach succeeds is still an open question. However, it seems likely that linking efforts and knowledge from the various fields of science into a holistic bioinformatics perspective offers the opportunity to come one step closer to a solution to the question of the origin of life, which is one of the greatest mysteries of humankind. This paper illustrates some recent advancements in this area and points out possible directions for further research.

scholarly journals Following Up on Interdisciplinary Encounters: Benefits for Early Career Researchers

2018 ◽  
Vol 26 (S2) ◽  
pp. S6-S20 ◽  
Author(s):  
Helen Bridle
Keyword(s):  
Career Development ◽  
Interdisciplinary Research ◽  
Early Career ◽  
Project Delivery ◽  
Social Challenges ◽  
Early Career Researchers ◽  
The Future

Interdisciplinarity is often quoted as a means to solve the complex social challenges faced by humanity, and the future of research is thus seen as increasingly interdisciplinary. However, there are risks and challenges to embarking on interdisciplinary research, particularly for early-career researchers. Encounters – bringing together early-career researchers to cultivate their interdisciplinary skills or to develop new projects – have been proposed and trialled as a means to boost interdisciplinarity amongst early-career researchers and equip them with the necessary skills for successful project delivery. However, little follow-up evaluation has been undertaken, especially considering career impacts several years after encounter participation. This article focuses on two encounter types and evaluates the level of interdisciplinary interactions obtained and the benefits experienced by participants. In conclusion, encounters are found to be highly successful, resulting in many projects and skills/career development. As such, further funding should be allocated to this type of event.

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