scholarly journals The Origin and Early Evolution of Life: Prebiotic Chemistry

Life ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 73 ◽  
Author(s):  
Michele Fiore

Microfossil evidence indicates that cellular life on Earth emerged during the Paleoarchean era be-tween 3 [...]

2014 ◽  
Vol 57 (5) ◽  
pp. 897-902 ◽  
Author(s):  
AnHuai Lu ◽  
Xin Wang ◽  
Yan Li ◽  
HongRui Ding ◽  
ChangQiu Wang ◽  
...  

2019 ◽  
Vol 201 (15) ◽  
Author(s):  
Milton H. Saier

ABSTRACTThe universal triple-nucleotide genetic code is often viewed as a given, randomly selected through evolution. However, as summarized in this article, many observations and deductions within structural and thermodynamic frameworks help to explain the forces that must have shaped the code during the early evolution of life on Earth.


1990 ◽  
Vol 18 (1) ◽  
pp. 317-356 ◽  
Author(s):  
J Oro ◽  
S L Miller ◽  
A Lazcano

2018 ◽  
Vol 19 (10) ◽  
pp. 3275 ◽  
Author(s):  
Yunsoo Kim ◽  
Bruce Kowiatek ◽  
Kristopher Opron ◽  
Zachary Burton

Because tRNA is the core biological intellectual property that was necessary to evolve translation systems, tRNAomes, ribosomes, aminoacyl-tRNA synthetases, and the genetic code, the evolution of tRNA is the core story in evolution of life on earth. We have previously described the evolution of type-I tRNAs. Here, we use the same model to describe the evolution of type-II tRNAs, with expanded V loops. The models are strongly supported by inspection of typical tRNA diagrams, measuring lengths of V loop expansions, and analyzing the homology of V loop sequences to tRNA acceptor stems. Models for tRNA evolution provide a pathway for the inanimate-to-animate transition and for the evolution of translation systems, the genetic code, and cellular life.


Life ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 17 ◽  
Author(s):  
Peter Strazewski

Extant life uses two kinds of linear biopolymers that mutually control their own production, as well as the cellular metabolism and the production and homeostatic maintenance of other biopolymers. Nucleic acids are linear polymers composed of a relatively low structural variety of monomeric residues, and thus a low diversity per accessed volume. Proteins are more compact linear polymers that dispose of a huge compositional diversity even at the monomeric level, and thus bear a much higher catalytic potential. The fine-grained diversity of proteins makes an unambiguous information transfer from protein templates too error-prone, so they need to be resynthesized in every generation. But proteins can catalyse both their own reproduction as well as the efficient and faithful replication of nucleic acids, which resolves in a most straightforward way an issue termed “Eigen’s paradox”. Here the importance of the existence of both kinds of linear biopolymers is discussed in the context of the emergence of cellular life, be it for the historic orgin of life on Earth, on some other habitable planet, or in the test tube. An immediate consequence of this analysis is the necessity for translation to appear early during the evolution of life.


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