Polyelectrolyte Multilayers: An Overview on Fabrication, Properties, and Biomedical and Environmental Applications

Polyelectrolyte multilayers are versatile materials that are used in a large number of domains, including biomedical and environmental applications. The fabrication of polyelectrolyte multilayers using the layer-by-layer technique is one of the simplest methods to obtain composite functional materials. The properties of the final material can be easily tuned by changing the deposition conditions and the used building blocks. This review presents the main characteristics of polyelectrolyte multilayers, the fabrication methods currently used, and the factors influencing the layer-by-layer assembly of polyelectrolytes. The last section of this paper presents some of the most important applications of polyelectrolyte multilayers, with a special focus on biomedical and environmental applications.

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Effect of metal ions on physical properties of multilayers from hyaluronan and chitosan and adhesion, growth and adipogenic differentiation of multipotent mouse fi-broblasts

Soft Matter ◽

10.1039/d1sm00405k ◽

2021 ◽

Author(s):

Husnia Muftah Kindi ◽

Matthias Menzel ◽

Andreas Heilmann ◽

Christian EH Schmelzer ◽

Martin Herzberg ◽

...

Keyword(s):

Hyaluronic Acid ◽

Physical Properties ◽

Metal Ions ◽

Adipogenic Differentiation ◽

Polyelectrolyte Multilayers ◽

Layer By Layer ◽

Layer Technique ◽

Layer By Layer Technique

Polyelectrolyte multilayers (PEM) consisting of the polysaccharides hyaluronic acid (HA) as polyanion and chitosan (Chi) as polycation are prepared by the layer-by-layer technique (LbL). The [Chi/HA]5 multilayers are exposed to...

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Compartmentalized bioencapsulated liquefied 3D macro-construct by perfusion-based layer-by-layer technique

RSC Advances ◽

10.1039/c4ra11674g ◽

2015 ◽

Vol 5 (4) ◽

pp. 2511-2516 ◽

Cited By ~ 8

Author(s):

Praveen Sher ◽

Clara R. Correia ◽

Rui R. Costa ◽

João F. Mano

Keyword(s):

Building Blocks ◽

Layer By Layer ◽

Hydrogel Beads ◽

Layer Technique ◽

Organ Printing ◽

Layer By Layer Technique

A novel biofabrication process via perfusion-based LbL technique for bioencapsulated hydrogel beads as building blocks to produce freeform 3D construct with controllable switching of a solid to liquefied microenvironment for use in TE/organ printing.

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Layer-by-layer technique for enhancing physicochemical properties of actives

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2020.101519 ◽

2020 ◽

Vol 56 ◽

pp. 101519

Author(s):

Pravin Shende ◽

Amar Patil ◽

Bala Prabhakar

Keyword(s):

Physicochemical Properties ◽

Layer By Layer ◽

Layer Technique ◽

Layer By Layer Technique

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Pectin-Chitosan Multilayer Coated Microbeads of Diclofenac Sodium Prepared by Layer-by-Layer Technique

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1060.45 ◽

2014 ◽

Vol 1060 ◽

pp. 45-49

Author(s):

Kamonrak Cheewatanakornkool ◽

Pornsak Sriamornsak

Keyword(s):

Controlled Release ◽

Drug Release ◽

Diclofenac Sodium ◽

Gastric Fluid ◽

Layer By Layer ◽

Release Behavior ◽

Freeze Dried ◽

Layer Technique ◽

Calcium Pectinate ◽

Layer By Layer Technique

The main objective of this study was to fabricate biopolymer-based microbeads, providing enteric properties and controlled release of diclofenac sodium, using layer-by-layer technique. The calcium pectinate microbeads have been designed and coated with chitosan and pectin multilayers. Drug release was performed in simulate gastric fluid (pH 1.2) for 2 hours, followed by pH 6.8 buffer for 8 hours. The effects of chitosan concentration, number of layer and drying technique on drug release were investigated. The results showed that the calcium pectinate microbeads could be simply prepared by ionotropic gelation and then coated with chitosan and pectin solutions using layer-by-layer procedure. The diameter of the microbeads ranged from 800 to 1000 μm for air-dried samples and from 1 to 2 mm for freeze-dried samples. The freeze-dried microbeads had a rough surface and many pores inside, as observed by SEM. The microbeads coated with 4% chitosan/4% pectin revealed a slower drug release than those coated with 1% chitosan/4% pectin and demonstrated a controlled release pattern. Moreover, different drying techniques and numbers of layer also influenced drug release behavior of the prepared microbeads.

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