scholarly journals 20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 440 ◽  
Author(s):  
Xiao-Dong Li ◽  
Xin Li ◽  
Xiao-Ming Li ◽  
Gang-Ming Xu ◽  
Yang Liu ◽  
...  
Keyword(s):  
Deep Sea ◽  
Density Functional ◽  
Pathogenic Bacteria ◽  
Pathogenic Fungi ◽  
Antimicrobial Activities ◽  
Crystallographic Analysis ◽  
Edwardsiella Tarda ◽  
Separation And Purification ◽  
Deep Sea Sediment ◽  
Aspergillus Wentii

Four new uncommon 20-nor-isopimarane diterpenoid epimers, aspewentins I−L (1–4), together with a new methylated derivative of 3, aspewentin M (5), were isolated from the deep sea sediment-derived fungus Aspergillus wentii SD-310. The very similar structures of these epimers made the separation and purification procedures difficult. The structures of compounds 1–5 were illustrated based on spectroscopic analysis, and the absolute configurations of compounds 1–5 were unambiguously determined by the combination of NOESY, time-dependent density functional (TDDFT)-ECD calculations, and X-ray crystallographic analysis. These metabolites represented the rare examples of 20-nor-isopimarane analogues possessing a cyclohexa-2,5-dien-1-one moiety. These compounds were tested for antimicrobial activities against human and aquatic pathogenic bacteria, as well as plant-pathogenic fungi. While compounds 1 and 2 exhibited inhibitory activities against zoonotic pathogenic bacteria such as Escherichia coli, Edwardsiella tarda, Vibrio harveyi, and V. parahaemolyticus, compound 5 showed potent activity against the plant pathogen Fusarium graminearum.

scholarly journals Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330

Marine Drugs ◽  
2019 ◽  
Vol 17 (10) ◽  
pp. 563 ◽  
Author(s):  
Xiao-Dong Li ◽  
Xiao-Ming Li ◽  
Xiu-Li Yin ◽  
Xin Li ◽  
Bin-Gui Wang
Keyword(s):  
Deep Sea ◽  
Pathogenic Bacteria ◽  
Vibrio Anguillarum ◽  
Antimicrobial Activities ◽  
Crystallographic Analysis ◽  
Edwardsiella Tarda ◽  
Aspergillus Versicolor ◽  
Deep Sea Sediment ◽  
X Ray ◽  
The Absolute

Two new antimicrobial bisabolane-type sesquiterpenoid derivatives, ent-aspergoterpenin C (compound 1) and 7-O-methylhydroxysydonic acid (2), and two new butyrolactone-type monoterpenoids, pestalotiolactones C (3) and D (4), along with a known monoterpenoid pestalotiolactone A (5) and four known bisabolane sesquiterpenoids (6−9), were isolated and identified from the deep-sea sediment-derived fungus Aspergillus versicolor SD-330. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and the absolute configurations of the new compounds 1−4 were determined by the combination of NOESY and TDDFT-ECD calculations and X-ray crystallographic analysis. Additionally, we first determined and reported the absolute configuration of the known monoterpenoid pestalotiolactone A (5) through the X-ray crystallographic experiment. All of these isolated compounds were evaluated for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1, 2, 6 and 9 exhibited selective inhibitory activities against zoonotic pathogenic bacteria such as Escherichia coli, Edwardsiella tarda, Vibrio anguillarum and V. harveyi, with MIC values ranging from 1.0 to 8.0 μg/mL.

scholarly journals Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406

Marine Drugs ◽  
2021 ◽  
Vol 20 (1) ◽  
pp. 4
Author(s):  
Li-Hong Yan ◽  
Xiao-Ming Li ◽  
Lu-Ping Chi ◽  
Xin Li ◽  
Bin-Gui Wang
Keyword(s):  
Aspergillus Fumigatus ◽  
Deep Sea ◽  
Pathogenic Bacteria ◽  
Pathogenic Fungus ◽  
Crystallographic Analysis ◽  
Amide Bond ◽  
Chiral Hplc ◽  
Deep Sea Sediment ◽  
Ring Compounds ◽  
Antimicrobial Metabolites

Six new metabolites, including a pair of inseparable mixtures of secofumitremorgins A (1a) and B (1b), which differed in the configuration of the nitrogen atom, 29-hydroxyfumiquinazoline C (6), 10R-15-methylpseurotin A (7), 1,4,23-trihydroxy-hopane-22,30-diol (10), and sphingofungin I (11), together with six known compounds (2–5 and 8–9), were isolated and identified from the deep-sea sediment-derived fungus Aspergillus fumigatus SD-406. Their structures were determined by detailed spectroscopic analysis of NMR and MS data, chiral HPLC analysis of the acidic hydrolysate, X-ray crystallographic analysis, J-based configuration analysis, and quantum chemical calculations of ECD, OR, and NMR (with DP4+ probability analysis). Among the compounds, 1a/1b represent a pair of novel scaffolds derived from indole diketopiperazine by cleavage of the amide bond following aromatization to give a pyridine ring. Compounds 1, 4, 6, 7, 10 and 11 showed inhibitory activities against pathogenic bacteria and plant pathogenic fungus, with MIC values ranging from 4 to 64 μg/mL.

scholarly journals Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus Penicillium cyclopium SD-413

Marine Drugs ◽  
2020 ◽  
Vol 18 (11) ◽  
pp. 553
Author(s):  
Yan-He Li ◽  
Xiao-Ming Li ◽  
Xin Li ◽  
Sui-Qun Yang ◽  
Xiao-Shan Shi ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Deep Sea ◽  
Density Functional ◽  
Pathogenic Bacteria ◽  
Micrococcus Luteus ◽  
Vibrio Anguillarum ◽  
2D Nmr ◽  
Edwardsiella Tarda ◽  
Spectrometric Analysis ◽  
Mic Minimum Inhibitory Concentration

Nine secondary metabolites (1–9), including two new polyketide derivatives 9-dehydroxysargassopenilline A (4) and 1,2-didehydropeaurantiogriseol E (5), along with seven known related secondary metabolites (1–3 and 6–9), were isolated and identified from the deep sea-derived fungus Penicilliumcyclopium SD-413. Their structures were elucidated on the basis of 1D/2D NMR spectroscopic and mass spectrometric analysis and the absolute configurations were determined by the combination of NOESY correlations and time-dependent density functional (TDDFT) ECD calculations. Compounds 1–9 inhibited some pathogenic bacteria including Escherichia coli, E. ictaluri, Edwardsiella tarda, Micrococcus luteus, Vibrio anguillarum, and V. harveyi, with MIC (minimum inhibitory concentration) values ranging from 4 to 32 μg/mL.

Tetranorlabdane Diterpenoids from the Deep Sea Sediment-Derived Fungus Aspergillus wentii SD-310

Planta Medica ◽  
2016 ◽  
Vol 82 (09/10) ◽  
pp. 877-881 ◽  
Author(s):  
Xiao-Dong Li ◽  
Xin Li ◽  
Xiao-Ming Li ◽  
Gang-Ming Xu ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Deep Sea ◽  
Deep Sea Sediment ◽  
Aspergillus Wentii

20-Nor-isopimarane cycloethers from the deep-sea sediment-derived fungus Aspergillus wentii SD-310

RSC Advances ◽  
2016 ◽  
Vol 6 (79) ◽  
pp. 75981-75987 ◽  
Author(s):  
Xin Li ◽  
Xiao-Ming Li ◽  
Xiao-Dong Li ◽  
Gang-Ming Xu ◽  
Yang Liu ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Deep Sea ◽  
Tumor Cell Lines ◽  
Deep Sea Sediment ◽  
Aspergillus Wentii ◽  
Tetracyclic System

Five new 20-nor-isopimaranes, asperethers A–E (1–5), were isolated from the deep-sea derived fungus Aspergillus wentii SD-310. These compounds possess a unique 6/6/6/5 tetracyclic system and exhibited cytotoxicity against several tumor cell lines.

scholarly journals Synthesis, characterization and microbial screening of some new methyl 4, 6-o-(4-methoxybenzylidene)-?-D-glucopyranoside Derivatives

2014 ◽  
Vol 37 (2) ◽  
pp. 145-158 ◽  
Author(s):  
Sarkar MA Kawsar ◽  
Abul K MS Kabir ◽  
Mohammad M R Bhuiyan ◽  
Jannatul Ferdous ◽  
Mohammad S Rahman
Keyword(s):  
Pathogenic Bacteria ◽  
Pathogenic Fungi ◽  
Antimicrobial Activities ◽  
Bacterial Strains ◽  
Additional Information ◽  
Fungal Phytopathogens ◽  
New Compounds ◽  
Academy Of Sciences ◽  
Derivatives Of

Regioselective pentanoylation of methyl 4,6-O-(4-methoxybenzylidene)-?-D-glucopyranoside by the direct acylation method provided the methyl 4,6-O-(4-methoxybenzylidene)-2-O-pentanoyl- ?-D-glucopyranoside in good yield. A number of 3-O-acyl derivatives of this 2-O-pentanoylation product were also prepared in order to obtain new compounds and also gather additional information for structure elucidation. The chemical structure of the newly synthesized compounds was characterized by analytical and spectral methods. Synthesized acylated derivatives of Dglucopyranoside were screened for in vitro antimicrobial activities against ten human pathogenic bacteria and four plant pathogenic fungi. The study revealed that the acylated products exhibited moderate to good antimicrobial activities. It was interesting to observe that the selected compounds were more sensitive against fungal phytopathogens than those of the bacterial strains. DOI: http://dx.doi.org/10.3329/jbas.v37i2.17554 Journal of Bangladesh Academy of Sciences, Vol. 37, No. 2, 145-158, 2013

scholarly journals Wentinoids A–F, six new isopimarane diterpenoids from Aspergillus wentii SD-310, a deep-sea sediment derived fungus

RSC Advances ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. 4387-4394 ◽  
Author(s):  
Xin Li ◽  
Xiao-Dong Li ◽  
Xiao-Ming Li ◽  
Gang-Ming Xu ◽  
Yang Liu ◽  
...  
Keyword(s):  
Deep Sea ◽  
Deep Sea Sediment ◽  
Aspergillus Wentii

Wentinoids A–F (1–6), presented as the first examples of isopimarane analogues from the fungus Aspergillus wentii, were isolated and identified.

scholarly journals The novel metallo-β-lactamase PNGM-1 from a deep-sea sediment metagenome: crystallization and X-ray crystallographic analysis

2018 ◽  
Vol 74 (10) ◽  
pp. 644-649 ◽  
Author(s):  
Kwang Seung Park ◽  
Myoung-Ki Hong ◽  
Jin Wan Jeon ◽  
Ji Hwan Kim ◽  
Jeong Ho Jeon ◽  
...  
Keyword(s):  
Deep Sea ◽  
Metagenomic Library ◽  
Crystallographic Analysis ◽  
Monoclinic Space Group ◽  
The Novel ◽  
Unit Cell Parameters ◽  
Deep Sea Sediment ◽  
X Ray ◽  
Cell Parameters ◽  
Great Health

Metallo-β-lactamases (MBLs) are present in major Gram-negative pathogens and environmental species, and pose great health risks because of their ability to hydrolyze the β-lactam rings of antibiotics such as carbapenems. PNGM-1 was the first reported case of a subclass B3 MBL protein that was identified from a metagenomic library from deep-sea sediments that predate the antibiotic era. In this study, PNGM-1 was overexpressed, purified and crystallized. Crystals of native and selenomethionine-substituted PNGM-1 diffracted to 2.10 and 2.30 Å resolution, respectively. Both the native and the selenomethionine-labelled PNGM-1 crystals belonged to the monoclinic space group P21, with unit-cell parameters a = 122, b = 83, c = 163 Å, β = 110°. Matthews coefficient (V M) calculations suggested the presence of 6–10 molecules in the asymmetric unit, corresponding to a solvent content of ∼31–58%. Structure determination is currently in progress.

scholarly journals Comparative Antimicrobial Activities of some Monosaccharide and Disaccharide Acetates

2013 ◽  
Vol 5 (3) ◽  
pp. 515-525 ◽  
Author(s):  
M. M. Matin ◽  
M. M. H. Bhuiyan ◽  
A. Afrin ◽  
D. C. Debnath
Keyword(s):  
Pathogenic Bacteria ◽  
Pathogenic Fungi ◽  
Salmonella Typhi ◽  
Antimicrobial Activities ◽  
Shigella Dysenteriae ◽  
Curvularia Lunata ◽  
Sucrose Octaacetate ◽  
Antimicrobial Studies ◽  
Activity Structure

A number of furanose (2,4) and pyranose (5,7,9,11,13) acetates were prepared by direct acetylation method. For comparative antimicrobial studies sucrose octaacetate (14) was also prepared. All the compounds (1-14) were screened for in vitro antibacterial activity against ten human pathogenic bacteria viz. Bacillus subtilis, Bacillus cereus, Bacillus megaterium, Staphylococcus aureus, Escherichia coli, INABA ET (Vibrio), Pseudomonas species, Salmonella paratyphi, Salmonella typhi and Shigella dysenteriae. These compounds were also screened for in vitro antifungal activity against four pathogenic fungi viz. Aspergillus niger, Alternaria alternata, Curvularia lunata and Fusarium equiseti. The study revealed that the pyranose acetate derivatives (5,7,9,11,13) are more prone towards antimicrobial functionality than those of the furanose acetates (2,4) and sucrose octaacetate (14).  Keywords: Glucofuranose; Glucopyranose; Acetylation; Antimicrobial activity; Structure activity relationship (SAR).  © 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.  doi: http://dx.doi.org/10.3329/jsr.v5i3.15695 J. Sci. Res. 5 (3), 515-525 (2013)

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