scholarly journals Natural Products from Cyanobacteria: Focus on Beneficial Activities

Marine Drugs ◽  
2019 ◽  
Vol 17 (6) ◽  
pp. 320 ◽  
Author(s):  
Justine Demay ◽  
Cécile Bernard ◽  
Anita Reinhardt ◽  
Benjamin Marie
Keyword(s):  
Natural Products ◽  
Molecular Diversity ◽  
Direct Relationship ◽  
Extreme Environments ◽  
Toxin Production ◽  
Ecological Niches ◽  
Synthetic Analog ◽  
Photosynthetic Microorganisms ◽  
Chemical Class ◽  
Dolastatin 10

Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products that they synthesize, support cyanobacterial success in colonization of their respective ecological niches. Although cyanobacteria are well-known for their toxin production and their relative deleterious consequences, they also produce a large variety of molecules that exhibit beneficial properties with high potential in various fields (e.g., a synthetic analog of dolastatin 10 is used against Hodgkin’s lymphoma). The present review focuses on the beneficial activities of cyanobacterial molecules described so far. Based on an analysis of 670 papers, it appears that more than 90 genera of cyanobacteria have been observed to produce compounds with potentially beneficial activities in which most of them belong to the orders Oscillatoriales, Nostocales, Chroococcales, and Synechococcales. The rest of the cyanobacterial orders (i.e., Pleurocapsales, Chroococcidiopsales, and Gloeobacterales) remain poorly explored in terms of their molecular diversity and relative bioactivity. The diverse cyanobacterial metabolites possessing beneficial bioactivities belong to 10 different chemical classes (alkaloids, depsipeptides, lipopeptides, macrolides/lactones, peptides, terpenes, polysaccharides, lipids, polyketides, and others) that exhibit 14 major kinds of bioactivity. However, no direct relationship between the chemical class and the respective bioactivity of these molecules has been demonstrated. We further selected and specifically described 47 molecule families according to their respective bioactivities and their potential uses in pharmacology, cosmetology, agriculture, or other specific fields of interest. With this up-to-date review, we attempt to present new perspectives for the rational discovery of novel cyanobacterial metabolites with beneficial bioactivity.

scholarly journals Natural Products from Cyanobacteria: Focus on Beneficial Activities

2019 ◽  
Author(s):  
Justine Demay ◽  
Cécile Bernard ◽  
Anita Reinhardt ◽  
Benjamin Marie
Keyword(s):  
Natural Products ◽  
Biosynthetic Pathway ◽  
Molecular Diversity ◽  
Extreme Environments ◽  
Toxin Production ◽  
Ecological Niches ◽  
Synthetic Analog ◽  
Direct Relation ◽  
Photosynthetic Microorganisms ◽  
Chemical Class

Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products (molecules, metabolites, or compounds) that they synthesize support the cyanobacterial success for the colonization of their respective ecological niches. Although cyanobacteria are well-known for their toxin production and their relative deleterious consequences, they also produce a large variety of molecules that exhibit beneficial properties with high potential for various fields of application (e.g., synthetic analog of the dolastatin 10 used against Hodgkin lymphoma). The present review specially focuses on the beneficial activities of cyanobacterial molecules described so far. Based on an analysis of 670 papers, it appears that more than 90 genera of cyanobacteria have been found to produce compounds with potential beneficial activities, most of them belonging to the orders Oscillatoriales, Nostocales Chroococcales, and Synechococcales. The rest of the cyanobacterial orders (i.e., Pleurocapsales, Chroococcidiopsales, and Gloeobacterales) remain poorly explored in terms of their molecular diversity and relative bioactivity. The diverse cyanobacterial molecules presenting beneficial bioactivities belong to 10 different chemical classes (alkaloids, depsipeptides, lipopeptides, macrolides/lactones, peptides, terpenes, polysaccharides, lipids, polyketides, and others) that exhibit 14 major kinds of bioactivity. However, no direct relation between the chemical class and the bioactivity of these molecules has been demonstrated. We further selected and specifically described 50 molecule families according to their specific bioactivities and their potential uses in pharmacology, cosmetology, agriculture, or other specific fields of interest. This up-to-date review takes advantage of the recent progresses in genome sequencing and biosynthetic pathway elucidation, and presents new perspectives for the rational discovery of new cyanobacterial metabolites with beneficial bioactivity.

A chemoinformatic analysis of atoms, scaffolds and functional groups in natural products

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Joelle Ngo Hanna ◽  
Boris D. Bekono ◽  
Luc C. O. Owono ◽  
Flavien A. A. Toze ◽  
James A. Mbah ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Physicochemical Properties ◽  
Functional Groups ◽  
Atomic Composition ◽  
Synthetic Compounds ◽  
Chemical Libraries ◽  
Synthetic Drugs ◽  
Drugs Analysis ◽  
Chemical Class

Abstract In the quest to know why natural products (NPs) have often been considered as privileged scaffolds for drug discovery purposes, many investigations into the differences between NPs and synthetic compounds have been carried out. Several attempts to answer this question have led to the investigation of the atomic composition, scaffolds and functional groups (FGs) of NPs, in comparison with synthetic drugs analysis. This chapter briefly describes an atomic enumeration method for chemical libraries that has been applied for the analysis of NP libraries, followed by a description of the main differences between NPs of marine and terrestrial origin in terms of their general physicochemical properties, most common scaffolds and “drug-likeness” properties. The last parts of the work describe an analysis of scaffolds and FGs common in NP libraries, focusing on huge NP databases, e.g. those in the Dictionary of Natural Products (DNP), NPs from cyanobacteria and the largest chemical class of NP – terpenoids.

scholarly journals Microbial Transformations of Organically Fermented Foods

Metabolites ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 165 ◽  
Author(s):  
Ruma Raghuvanshi ◽  
Allyssa G. Grayson ◽  
Isabella Schena ◽  
Onyebuchi Amanze ◽  
Kezia Suwintono ◽  
...  
Keyword(s):  
Natural Products ◽  
Fermentation Process ◽  
Molecular Diversity ◽  
Food Type ◽  
Fermented Foods ◽  
Microbial Fermentation ◽  
Soil Community ◽  
Specialized Metabolites ◽  
The World ◽  
Salt Brine

Fermenting food is an ancient form of preservation ingrained many in human societies around the world. Westernized diets have moved away from such practices, but even in these cultures, fermented foods are seeing a resurgent interested due to their believed health benefits. Here, we analyze the microbiome and metabolome of organically fermented vegetables, using a salt brine, which is a common ‘at-home’ method of food fermentation. We found that the natural microbial fermentation had a strong effect on the food metabolites, where all four foods (beet, carrot, peppers and radishes) changed through time, with a peak in molecular diversity after 2–3 days and a decrease in diversity during the final stages of the 4-day process. The microbiome of all foods showed a stark transition from one that resembled a soil community to one dominated by Enterobacteriaceae, such as Erwinia spp., within a single day of fermentation and increasing amounts of Lactobacillales through the fermentation process. With particular attention to plant natural products, we observed significant transformations of polyphenols, triterpenoids and anthocyanins, but the degree of this metabolism depended on the food type. Beets, radishes and peppers saw an increase in the abundance of these compounds as the fermentation proceeded, but carrots saw a decrease through time. This study showed that organically fermenting vegetables markedly changed their chemistry and microbiology but resulted in high abundance of Enterobacteriaceae which are not normally considered as probiotics. The release of beneficial plant specialized metabolites was observed, but this depended on the fermented vegetable.

Regioselective enzymatic acylation of complex natural products: expanding molecular diversity

2011 ◽  
Vol 40 (11) ◽  
pp. 5321 ◽  
Author(s):  
Javier González-Sabín ◽  
Roberto Morán-Ramallal ◽  
Francisca Rebolledo
Keyword(s):  
Natural Products ◽  
Molecular Diversity ◽  
Enzymatic Acylation

scholarly journals Baikalomycins A-C, New Aquayamycin-Type Angucyclines Isolated from Lake Baikal Derived Streptomyces sp. IB201691-2A

2020 ◽  
Vol 8 (5) ◽  
pp. 680
Author(s):  
Irina Voitsekhovskaia ◽  
Constanze Paulus ◽  
Charlotte Dahlem ◽  
Yuriy Rebets ◽  
Suvd Nadmid ◽  
...  
Keyword(s):  
Natural Products ◽  
Lake Baikal ◽  
Structure Elucidation ◽  
Genome Mining ◽  
Ecological Niches ◽  
Hydroxyl Groups ◽  
Streptomyces Sp ◽  
Drug Leads ◽  
Promising Source ◽  
Antiproliferative Activities

Natural products produced by bacteria found in unusual and poorly studied ecosystems, such as Lake Baikal, represent a promising source of new valuable drug leads. Here we report the isolation of a new Streptomyces sp. strain IB201691-2A from the Lake Baikal endemic mollusk Benedictia baicalensis. In the course of an activity guided screening three new angucyclines, named baikalomycins A–C, were isolated and characterized, highlighting the potential of poorly investigated ecological niches. Besides that, the strain was found to accumulate large quantities of rabelomycin and 5-hydroxy-rabelomycin, known shunt products in angucyclines biosynthesis. Baikalomycins A–C demonstrated varying degrees of anticancer activity. Rabelomycin and 5-hydroxy-rabelomycin further demonstrated antiproliferative activities. The structure elucidation showed that baikalomycin A is a modified aquayamycin with β-d-amicetose and two additional hydroxyl groups at unusual positions (6a and 12a) of aglycone. Baikalomycins B and C have alternating second sugars attached, α-l-amicetose and α-l-aculose, respectively. The gene cluster for baikalomycins biosynthesis was identified by genome mining, cloned using a transformation-associated recombination technique and successfully expressed in S. albus J1074. It contains a typical set of genes responsible for an angucycline core assembly, all necessary genes for the deoxy sugars biosynthesis, and three genes coding for the glycosyltransferase enzymes. Heterologous expression and deletion experiments allowed to assign the function of glycosyltransferases involved in the decoration of baikalomycins aglycone.

Molecular Diversity of the Ribulose-1,5-Diphosphate Carboxylase from Photosynthetic Microorganisms

Science ◽  
1968 ◽  
Vol 161 (3840) ◽  
pp. 482-484 ◽  
Author(s):  
L. E. Anderson ◽  
G. B. Price ◽  
R. C. Fuller
Keyword(s):  
Molecular Diversity ◽  
Photosynthetic Microorganisms

scholarly journals Bioactive Molecules from Extreme Environments II

Marine Drugs ◽  
2021 ◽  
Vol 19 (11) ◽  
pp. 642
Author(s):  
Daniela Giordano
Keyword(s):  
Natural Products ◽  
Functional Properties ◽  
Extreme Environments ◽  
Marine Organisms ◽  
Bioactive Molecules ◽  
Structural And Functional Properties

Marine organisms are known to produce a wide variety of natural products that are unique in terms of diversity, structural, and functional properties [...]

ChemInform Abstract: Regioselective Enzymatic Acylation of Complex Natural Products: Expanding Molecular Diversity

ChemInform ◽  
2012 ◽  
Vol 43 (6) ◽  
pp. no-no
Author(s):  
Javier Gonzalez-Sabin ◽  
Roberto Moran-Ramallal ◽  
Francisca Rebolledo
Keyword(s):  
Natural Products ◽  
Molecular Diversity ◽  
Enzymatic Acylation
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