scholarly journals Feasibility of Ultra-Low-Dose CT for Bronchoscopy of Peripheral Lung Lesions

Medicina ◽  
2020 ◽  
Vol 56 (9) ◽  
pp. 479 ◽  
Author(s):  
Jung Seop Eom ◽  
Geewon Lee ◽  
Jiyeon Roh ◽  
Hyun Sung Chung ◽  
Yeon Joo Jeong
Keyword(s):  
Thin Section ◽  
Wall Thickness ◽  
Low Dose ◽  
Standard Dose ◽  
Endobronchial Ultrasound ◽  
Lung Lesions ◽  
Low Dose Ct ◽  
Group 4 ◽  
Peripheral Lung ◽  
Group 2

Background and objectives: Thin-section computed tomography (CT) is essential for identifying small bronchi during bronchoscopy using radial endobronchial ultrasound. Some patients should receive an additional CT for a thin-section image. We performed a retrospective study with a prospectively collected database to identify the optimal radiation dose for thin-section CT during peripheral bronchoscopy. Materials and Methods: In total, 91 patients with peripheral lung lesions underwent thin-section CT (both standard CT as a reference and ultra-low-dose CT (ultra-LDCT)). The patients were randomly assigned to one of four groups according to the ultra-LDCT parameters: group 1 = 120 kVp, 25 mAs; group 2 = 100 kVp, 15 mAs; group 3 = 120 kVp, 5 mAs; and group 4 = 100 kVp, 5 mAs. Two radiologists and two physicians analyzed both the standard CT and ultra-LDCT. Results: The effective doses (EDs) of ultra-LDCT significantly differed among the four groups (median EDs were 0.88, 0.34, 0.19, and 0.12 mSv for groups 1–4, respectively; p < 0.001). Median differences in peripheral airway wall thickness were higher in group 4 than in other groups (differences in median wall thickness measured by two radiologists were 0.4–0.5 mm and 0.8–0.9 mm for groups 1–3 and group 4, respectively). Bronchus signs on ultra-LDCT in groups 1 and 2 were well correlated with those of the standard-dose CT (accuracies of two radiologists and two pulmonary physicians were 95–100%). Conclusions: Our results indicate that ultra-LDCT with ED of >0.34 mSv (ED of group 2) is feasible for peripheral bronchoscopy.

Feasibility of ultra-low dose CT for bronchoscopy of peripheral lung lesions

2020 ◽  
Author(s):  
Jung Seop Eom ◽  
Geewon Lee ◽  
Insu Kim ◽  
Hee Yun Seol ◽  
Jiyeon Roh ◽  
...  
Keyword(s):  
Thin Section ◽  
Wall Thickness ◽  
Low Dose ◽  
Standard Dose ◽  
Endobronchial Ultrasound ◽  
Lung Lesions ◽  
Low Dose Ct ◽  
Group 4 ◽  
Peripheral Lung ◽  
Group 2

Abstract Background Thin-section CT is essential for identification of small bronchi during bronchoscopy using radial endobronchial ultrasound. Some patients should receive an additional CT for a thin-section image. We performed a retrospective study with a prospectively collected database to identify the optimal radiation dose for thin-section CT during peripheral bronchoscopy. Methods In total, 91 patients with peripheral lung lesions underwent thin-section CT (both standard CT as a reference and ultra-low dose CT [LDCT]). The patients were randomly assigned to one of four groups according to the ultra-LDCT parameters: group 1 = 120 kVp, 25 mAs; group 2 = 100 kVp, 15 mAs; group 3 = 120 kVp, 5 mAs; and group 4 = 100 kVp, 5 mAs. Two radiologists and two physicians analyzed both the standard CT and ultra-LDCT. Results The effective doses (EDs) of ultra-LDCT significantly differed among the four groups (median EDs were 0.88, 0.34, 0.19, and 0.12 mSv for groups 1–4, respectively; P < 0.001). Median differences in peripheral airway wall thickness were higher in group 4 than in other groups (differences in median wall thickness measured by two radiologists were 0.4–0.5 mm and 0.8–0.9 mm for groups 1–3 and group 4, respectively). Bronchus signs on ultra-LDCT in groups 1 and 2 were well correlated with those of the standard dose CT (accuracies of two radiologists and two pulmonary physicians were 95–100%). Conclusions Our results indicate that ultra-LDCT with ED of > 0.34 mSv (ED of group 2) is feasible for peripheral bronchoscopy.

scholarly journals Standard-dose vs. low-dose CT protocols in the evaluation of localized lung lesions: Capability for lesion characterization—iLEAD study

2016 ◽  
Vol 3 ◽  
pp. 67-73 ◽  
Author(s):  
Takeshi Kubo ◽  
Yoshiharu Ohno ◽  
Daisuke Takenaka ◽  
Mizuki Nishino ◽  
Shiva Gautam ◽  
...  
Keyword(s):  
Low Dose ◽  
Standard Dose ◽  
Lung Lesions ◽  
Low Dose Ct ◽  
Lesion Characterization

scholarly journals Hypertrophy of unaffected cardiomyocytes correlates with severity of cardiomyopathy in female patients with Fabry disease

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Cristina Chimenti ◽  
Romina Verardo ◽  
Andrea Frustaci
Keyword(s):  
Fabry Disease ◽  
Wall Thickness ◽  
Left Ventricular ◽  
Female Patients ◽  
Maximal Wall Thickness ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract Aim To investigate the contribution of unaffected cardiomyocytes in Fabry disease cardiomyopathy. Findings Left ventricular (LV) endomyocardial biopsies from twenty-four females (mean age 53 ± 11 ys) with Fabry disease cardiomyopathy were studied. Diagnosis of FD was based on the presence of pathogenic GLA mutation, Patients were divided in four groups according with LV maximal wall thickness (MWT): group 1 MWT ≤ 10.5 mm, group 2 MWT 10.5–15 mm, group 3 MWT 16–20 mm, group 4 MWT > 20 mm. At histology mosaic of affected and unaffected cardiomyocytes was documented. Unaffected myocytes’ size ranged from normal to severe hypertrophy. Hypertrophy of unaffected cardiomyocytes correlated with severity of MWT (p < 0.0001, Sperman r 0,95). Hypertrophy of unaffected myocytes appear to concur to progression and severity of FDCM. It is likely a paracrine role from neighboring affected myocytes.

scholarly journals Low Dose X-Ray Sources and High Quantum Efficiency Sensors: The Next Challenge in Dental Digital Imaging?

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
Arnav R. Mistry ◽  
Daniel Uzbelger Feldman ◽  
Jie Yang ◽  
Eric Ryterski
Keyword(s):  
Low Dose ◽  
Image Resolution ◽  
X Ray ◽  
Imaging Technologies ◽  
Group 4 ◽  
X Ray Imaging ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

Objective(s). The major challenge encountered to decrease the milliamperes (mA) level in X-ray imaging systems is the quantum noise phenomena. This investigation evaluated dose exposure and image resolution of a low dose X-ray imaging (LDXI) prototype comprising a low mA X-ray source and a novel microlens-based sensor relative to current imaging technologies.Study Design. A LDXI in static (group 1) and dynamic (group 2) modes was compared to medical fluoroscopy (group 3), digital intraoral radiography (group 4), and CBCT scan (group 5) using a dental phantom.Results. The Mann-Whitney test showed no statistical significance(α=0.01)in dose exposure between groups 1 and 3 and 1 and 4 and timing exposure (seconds) between groups 1 and 5 and 2 and 3. Image resolution test showed group 1 > group 4 > group 2 > group 3 > group 5.Conclusions. The LDXI proved the concept for obtaining a high definition image resolution for static and dynamic radiography at lower or similar dose exposure and smaller pixel size, respectively, when compared to current imaging technologies. Lower mA at the X-ray source and high QE at the detector level principles with microlens could be applied to current imaging technologies to considerably reduce dose exposure without compromising image resolution in the near future.

A new low-dose CT examination compared with standard-dose CT in the diagnosis of acute sinusitis

2003 ◽  
Vol 13 (5) ◽  
pp. 976-980 ◽  
Author(s):  
T. Hagtvedt ◽  
T. Aaløkken ◽  
J. Nøtthellen ◽  
A. Kolbenstvedt
Keyword(s):  
Low Dose ◽  
Standard Dose ◽  
Acute Sinusitis ◽  
Low Dose Ct ◽  
Ct Examination

Air Trapping: Comparison of Standard-Dose and Simulated Low-Dose Thin-Section CT Techniques

Radiology ◽  
2007 ◽  
Vol 242 (3) ◽  
pp. 898-906 ◽  
Author(s):  
Alexander A. Bankier ◽  
Cornelia Schaefer-Prokop ◽  
Viviane De Maertelaer ◽  
Denis Tack ◽  
Peter Jaksch ◽  
...  
Keyword(s):  
Thin Section ◽  
Low Dose ◽  
Standard Dose ◽  
Air Trapping

Comparison of low dose CT and standard dose Cone-beam CT for periprocedural 3D-planning of TIPSS guidance

2020 ◽  
Author(s):  
A Estler ◽  
K Nikolaou ◽  
R Hoffmann ◽  
J Herrmann ◽  
U Grosse ◽  
...  
Keyword(s):  
Low Dose ◽  
Standard Dose ◽  
Cone Beam Ct ◽  
Cone Beam ◽  
Low Dose Ct

Prediction of invasive adenocarcinomas manifesting as pure ground-glass nodules based on radiomic signature of low-dose CT in lung cancer screening

2022 ◽  
Author(s):  
Yong Li ◽  
Jieke Liu ◽  
Xi Yang ◽  
Hao Xu ◽  
Haomiao Qing ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Screening ◽  
Low Dose ◽  
Validation Cohort ◽  
Standard Dose ◽  
Lung Cancer Screening ◽  
Ground Glass ◽  
Semantic Features ◽  
Low Dose Ct ◽  
Ground Glass Nodules

Objectives: To develop a radiomic model based on low-dose CT (LDCT) to distinguish invasive adenocarcinomas (IAs) from adenocarcinoma in situ/minimally invasive adenocarcinomas (AIS/MIAs) manifesting as pure ground-glass nodules (pGGNs) and compare its performance with conventional quantitative and semantic features of LDCT, radiomic model of standard-dose CT, and intraoperative frozen section (FS). Methods: A total of 147 consecutive pathologically confirmed pGGNs were divided into primary cohort (43 IAs and 60 AIS/MIAs) and validation cohort (19 IAs and 25 AIS/MIAs). Logistic regression models were built using conventional quantitative and semantic features, selected radiomic features of LDCT and standard-dose CT, and intraoperative FS diagnosis, respectively. The diagnostic performance was assessed by area under curve (AUC) of receiver operating characteristic curve, sensitivity, and specificity. Results: The AUCs of quantitative-semantic model, radiomic model of LDCT, radiomic model of standard-dose CT, and FS model were 0.879 (95% CI, 0.801–0.935), 0.929 (95% CI, 0.862–0.971), 0.941 (95% CI, 0.876–0.978), and 0.884 (95% CI, 0.805–0.938) in the primary cohort and 0.897 (95% CI, 0.768–0.968), 0.933 (95% CI, 0.815–0.986), 0.901 (95% CI, 0.773–0.970), and 0.828 (95% CI, 0.685–0.925) in the validation cohort. No significant difference of the AUCs was found among these models in both the primary and validation cohorts (all p > 0.05). Conclusions: The LDCT-based quantitative-semantic score and radiomic signature, with good predictive performance, can be preoperative and non-invasive biomarkers for assessing the invasive risk of pGGNs in lung cancer screening. Advances in knowledge: The LDCT-based quantitative-semantic score and radiomic signature, with the equivalent performance to the radiomic model of standard-dose CT, can be preoperative predictors for assessing the invasiveness of pGGNs in lung cancer screening and reducing excess examination and treatment.

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