scholarly journals Neutropenic Enterocolitis and Sepsis: Towards the Definition of a Pathologic Profile

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 638
Author(s):  
Giuseppe Bertozzi ◽  
Aniello Maiese ◽  
Giovanna Passaro ◽  
Alberto Tosoni ◽  
Antonio Mirijello ◽  
...  

Background: Neutropenic enterocolitis (NE), which in the past was also known as typhlitis or ileocecal syndrome for the segment of the gastrointestinal tract most affected, is a nosological entity that is difficult to diagnose and whose pathogenesis is not fully known to date. Initially described in pediatric patients with leukemic diseases, it has been gradually reported in adults with hematological malignancies and non-hematological conditions, such as leukemia, lymphoma, multiple myeloma, aplastic anemia, and also myelodysplastic syndromes, as well as being associated with other immunosuppressive causes such as AIDS treatment, therapy for solid tumors, and organ transplantation. Therefore, it is associated with high mortality due to the rapid evolution in worse clinical pictures: rapid progression to ischemia, necrosis, hemorrhage, perforation, multisystem organ failure, and sepsis. Case report: A case report is included to exemplify the clinical profile of patients with NE who develop sepsis. Literature Review: To identify a specific profile of subjects affected by neutropenic enterocolitis and the entity of the clinical condition most frequently associated with septic evolution, a systematic review of the literature was conducted. The inclusion criteria were as follows: English language, full-text availability, human subjects, and adult subjects. Finally, the papers were selected after the evaluation of the title and abstract to evaluate their congruity with the subject of this manuscript. Following these procedures, 19 eligible empirical studies were included in the present review. Conclusions: Despite the recent interest and the growing number of publications targeting sepsis and intending to identify biomarkers useful for its diagnosis, prognosis, and for the understanding of its pathogenesis, and especially for multi-organ dysfunction, and despite the extensive research period of the literature review, the number of publications on the topic “neutropenic enterocolitis and sepsis” appears to be very small. In any case, the extrapolated data allowed us to conclude that the integration of medical history, clinical and laboratory data, radiological imaging, and macroscopic and histological investigations can allow us to identify a specific pathological profile.

1998 ◽  
Vol 37 (04) ◽  
pp. 141-145
Author(s):  
F. J. C. Pallarés ◽  
A. R. Bartual ◽  
Susana Tenes Rodrigo ◽  
F. J. Ampudia-Blasco ◽  
C. R. de Ávila y Ávalos ◽  
...  

SummaryA case of a 49-year-old man suffering from bilateral adrenocortical carcinoma with local and secondary rapid progression is reported. The results of adrenocortical scintigraphy (NP 59) and histological findings allowed the diagnosis. This case report and a literature review showed the importance of using adrenocortical scintigraphy as a complementary imaging procedure of CT or MR images.


Lupus ◽  
2020 ◽  
pp. 096120332096570
Author(s):  
Juliana P Ocanha-Xavier ◽  
Camila O Cola-Senra ◽  
Jose Candido C Xavier-Junior

Reticular erythematous mucinosis (REM) was first described 50 years ago, but only around 100 case reports in English have been published. Its relation with other inflammatory skin disorders is still being debated. We report a case of REM, including the clinical and histopathological findings. Also, a systematic review of 94 English-language reported cases is provided. The described criteria for clinical and histopathological diagnosis are highlighted in order to REM can be confidently diagnosed.


2006 ◽  
Vol 10 (5) ◽  
pp. 249-252 ◽  
Author(s):  
Anna Zampetti ◽  
Claudio Feliciani ◽  
Francesco Landi ◽  
M.L. Capaldo ◽  
M. Rotoli ◽  
...  

Background: The relationship between pregnancy and a change in melanocytic nevi is still controversial. Moreover, management of the rapid evolution of a nevus in an unauspicious melanocytic lesion can be a clinical challenge in pregnancy. Methods: This article examines a case of a fast-growing deep penetrating nevus in a pregnant woman and provides a literature review of articles relative to pregnancy and nevi change, the management of fast-growing pigmented lesions, and the role and usefulness of dermoscopy in these cases. Results: Recent studies have documented that pregnancy is not associated with any significant change in the size of melanocytic nevi. The management of fast-growing melanocytic lesions during this period compulsorily leans toward excision. Dermoscopy can be useful, providing clinicohistopathologic correlations and a better assignment of the lesion. Conclusion: This case report and review provide important management considerations for nevi during pregnancy. Early intervention with aggressive treatment measures is the best management for fast-growing lesions, and epiluminescence dermoscopy can assist the management, although still remaining a second-level examination, useful for documentation and for a better classification of the lesion.


2010 ◽  
Vol 27 (2) ◽  
pp. 313-321 ◽  
Author(s):  
Dimitrios Paraskevopoulos ◽  
Ioannis Patsalas ◽  
Georgios Karkavelas ◽  
Nikolaos Foroglou ◽  
Ioannis Magras ◽  
...  

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Sarah Nelson

The syndrome of transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL syndrome) is a self-limited condition. Confusional states are uncommonly reported as a clinical manifestation of this syndrome. Here, I report a 76-year-old female who presented with headache, confusion, and agitation with a mild CSF lymphocytosis. Other workup to determine the cause of her altered mental status was otherwise negative. The literature available in the English language on HaNDL syndrome is reviewed, including its history, pathophysiology, possible associations with migraine and stroke, and previously reported cases of confusional states in this syndrome. While HaNDL syndrome has been a described entity since the 1980s, its pathophysiology has yet to be clearly defined.


2018 ◽  
Vol 6 (16) ◽  
pp. 1164-1168
Author(s):  
Hee-Young Yoon ◽  
Yookyung Kim ◽  
Heae Surng Park ◽  
Chung-Won Kang ◽  
Yon Ju Ryu

2021 ◽  
pp. 104063872199460
Author(s):  
Jeann Leal de Araújo ◽  
Alice C. A. M. Arruda ◽  
Nayadjala T. A. Santos ◽  
Glenison F. Dias ◽  
Thiago F. L. Nery ◽  
...  

A 4-mo-old northern red-shouldered macaw ( Diopsittaca nobilis) was admitted to the veterinary hospital of the Arruda Câmara Zoo, in the State of Paraiba, Brazil, for investigation of an orbital mass. Given rapid progression and lack of response to treatment, the bird was euthanized, and an autopsy was performed. Histologically, the mass consisted of a retrobulbar invasive tumor characterized by tubular and rosette-like structures, with interspersed heteroplastic tissues, such as aggregates of neuroglial cells and islands of hyaline cartilage. The tumor was immunopositive for pancytokeratin, GFAP, NSE, and S100. These findings were compatible with an ocular teratoid medulloepithelioma, a neoplasm best described in humans but also reported rarely in young cockatiels and African Grey parrots.


2015 ◽  
Vol 9 (6) ◽  
pp. 2713-2715 ◽  
Author(s):  
QIONG WANG ◽  
JING CHEN ◽  
MEERA DASSARATH ◽  
ZHONGYUAN YIN ◽  
XIUPING YANG ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document