scholarly journals Drug-Induced Esophageal Ulcer in Adolescent Population: Experience at a Single Medical Center in Central Taiwan

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1286
Author(s):  
Shu-Wei Hu ◽  
An-Chyi Chen ◽  
Shu-Fen Wu
Keyword(s):  
Gastrointestinal Endoscopy ◽  
Pediatric Patients ◽  
Upper Gastrointestinal Endoscopy ◽  
Esophageal Ulcer ◽  
Drug Induced ◽  
Inflammatory Drugs ◽  
The Mean ◽  
Anti Inflammatory ◽  
Upper Gastrointestinal ◽  
Esophageal Ulcers

Background and Objectives: Drug-induced esophageal ulcer is caused by focal drug stimulation. It may occur in adults and children. Limited research is available in pediatric patients with drug-induced esophageal ulcer; therefore, we designed this study to determine the characteristics of this disease in this population. Materials and Methods: Thirty-two pediatric patients diagnosed with drug-induced esophageal ulcers from a hospital database of upper gastrointestinal tract endoscopies were included. After treatment, patients were followed for 2 months after upper gastrointestinal endoscopy. Results: Female patients were predominant (56.2%/43.8%). The mean age of patients was 15.6 years (median, 16 years; interquartile range, 2 years). Doxycycline was administered in most cases (56.3%); other drugs were dicloxacillin, amoxicillin, clindamycin, L-arginine, and nonsteroidal anti-inflammatory drugs. Doxycycline was associated with kissing ulcers. Esophageal ulcers induced by nonsteroidal anti-inflammatory drugs were more often associated with gastric or duodenal ulcers. The most common location was the middle-third of the esophagus (78.1%). Patients were treated with proton pump inhibitors, sucralfate, or H2-blockers. The mean duration for which symptoms lasted was 9.2 days. No esophageal stricture was found in 24 patients who were followed for 2 months after upper gastrointestinal endoscopy. Conclusions: The authors suggest informing patients to take medicine with enough water (approximately 100 mL) and enough time (15–30 min) before recumbency, especially high-risk drugs, such as doxycycline or nonsteroidal anti-inflammatory drugs.

Esophageal Polyps in Pediatric Patients Undergoing Upper Gastrointestinal Endoscopy

2008 ◽  
Vol 67 (5) ◽  
pp. AB78-AB79
Author(s):  
Seth S. Septer ◽  
Carmen Cuffari ◽  
Christine Reyes ◽  
Neil J. Rawlinson ◽  
Thomas Attard
Keyword(s):  
Gastrointestinal Endoscopy ◽  
Pediatric Patients ◽  
Upper Gastrointestinal Endoscopy ◽  
Upper Gastrointestinal

scholarly journals Helicobacter pylori Infection: Clinical, Endoscopic, and Histological Findings in Lebanese Pediatric Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
F. AL Kirdy ◽  
M. Rajab ◽  
N. El-Rifai
Keyword(s):  
Helicobacter Pylori ◽  
Gastrointestinal Endoscopy ◽  
Pediatric Patients ◽  
Epigastric Pain ◽  
Demographic Data ◽  
Upper Gastrointestinal Endoscopy ◽  
Histopathological Findings ◽  
Increased Risk ◽  
H Pylori ◽  
Upper Gastrointestinal

Background. Helicobacter pylori (H. pylori) is a common and universally distributed bacterial infection. However, in children, active gastritis and ulcer are rarely seen. Objectives. The aims of this study were to establish the prevalence of H. pylori infection and to compare the clinical, endoscopic, and histopathological findings between infected and noninfected pediatric patients at Makassed General Hospital. Methods. Patients aged between 1 month and 17 years who underwent upper gastrointestinal endoscopy from January 2011 to January 2017 were included. The diagnosis of H. pylori was confirmed by a CLO test and/or its presence on biopsy specimens. Demographic data, clinical characteristics, endoscopic and histopathological findings, and gastritis score were recorded retrospectively. Results. During the study period, 651 children underwent upper gastrointestinal endoscopy. The main indication was abdominal pain (61%). The prevalence of H. pylori infection was 16.5%. The infection was most commonly seen among children aged between 6 and 10 years (43%). A large number of family members were associated with increased risk of infection (4.8±1.5 versus 5.2±1.8; p<0.05). Epigastric pain was more associated with H. pylori (61.3% versus 14.6% in noninfected patients; p<0.05). Nodular gastritis was commonly seen in infected patients (41.5% vs. 7.9%; p<0.05). Mild and moderate gastritis was seen more in infected versus noninfected patients (mild: 53.8% vs. 14%; moderate: 27.4% vs. 2.4%, respectively). Conclusion. Although epigastric pain was associated with H. pylori, other diagnoses should be considered since the infection are rarely symptomatic in children. Antral nodularity was associated with H. pylori infection; however, its absence does not preclude the diagnosis.

scholarly journals HELICOBACTER PYLORI INFECTION;

2012 ◽  
Vol 19 (02) ◽  
pp. 202-207
Author(s):  
NABIHA FAISAL ◽  
MUHAMMAD MANSOOR UL HAQ ◽  
HAFEEZULLAH SHAIKH ◽  
Pervez Ashraf ◽  
Jamila. H. Esmail
Keyword(s):  
Gastrointestinal Endoscopy ◽  
Tertiary Care ◽  
Upper Gastrointestinal Endoscopy ◽  
National Hospital ◽  
Cross Sectional ◽  
Duration Of Symptoms ◽  
Data Source ◽  
The Mean ◽  
H Pylori ◽  
Upper Gastrointestinal

Objective: To determine the frequency of H. pylori infection in dyspeptic patients undergoing endoscopy at a tertiary care centerin Karachi. Data source: Patients undergoing endoscopy at Liaquat National Hospital, Karachi. Design of study: Cross sectional descriptivestudy. Setting: Department of Gastroenterology, Liaquat National Hospital, Karachi. Period: May 2008–October 2008. Material andmethods: All adult patients with symptoms of dyspepsia for more than 1 month duration were included. Patients with upper gastrointestinalbleed, anemia or weight loss were excluded. Upper gastrointestinal endoscopy was performed in all patients and biopsy specimens two eachfrom antrum and body and one from fundus were taken for histology. Results: A total of 123 dyspeptic patients were included in the study. 76(61.8%) patients were males and 47 (38.2%) were females. H pylori was detected in mucosa of 49 (39.8%) patients. The mean age of thepatients was 41.41 ± 13.15 Years (95%CI; 39.06 to 43.75). Rate of H.pylori infection was not found statistical significant with age, gender,duration of symptoms and BMI. Conclusions: The prevalence of H pylori infection in dyspeptic patients was lower than reported in previousstudies from other centers in Pakistan. Other environmental factors should be evaluated in every patient especially who is negative for H. pyloriin our setup.

scholarly journals Pre-Endoscopy Drink of Simethicone and N-Acetylcysteine Significantly Improves Visualization in Upper Gastrointestinal Endoscopy

2021 ◽  
Vol 12 (01) ◽  
pp. 011-018
Author(s):  
Shrihari Anil Anikhindi ◽  
Ashish Kumar ◽  
Noriya Uedo ◽  
Vikas Singla ◽  
Akshay Anikhindi ◽  
...  
Keyword(s):  
Gastrointestinal Endoscopy ◽  
Duodenal Bulb ◽  
Gastric Fundus ◽  
Gastric Body ◽  
Upper Gastrointestinal Endoscopy ◽  
Optimal Outcomes ◽  
The Mean ◽  
The Difference ◽  
Upper Gastrointestinal ◽  
Control Study

Abstract Introduction With the advancements in diagnostic and therapeutic upper gastrointestinal endoscopy (UGIE), clear mucosal visualization is essential to ensure optimal outcomes. Though routinely followed in Japan and Korea, pre-endoscopic preparation is seldom used in India. We evaluated the efficacy of a pre-endoscopic drink of N-acetylcysteine (NAC) and simethicone in improving mucosal visibility during UGIE. Patients and Methods This study was a retrospective, investigator blind study with a case–control study design. Cases included patients who received a pre-endoscopy drink of NAC and simethicone in 100 mL water administered 10 to 30 minutes prior to UGIE. Controls only had mandatory fasting for 6 to 8 hours prior to UGIE. Propensity score matching was done to ensure comparability between the groups. Digital images were taken at six standard landmarks during UGIE and stored. A blinded investigator subsequently analyzed the images and rated the mucosal visibility on a 3-point scale. The difference in the mean mucosal visibility between the cases and controls was compared. Results Mean mucosal visibility during UGIE was significantly better using NAC with simethicone as compared with no preparation at esophagus (1.14 [0.37] vs. 1.47 [0.62], p < 0.05), gastric fundus (1.10 [0.30] vs. 1.55 [0.64], p < 0.05), gastric body (1.22 [0.50] vs. 1.62 [0.73], p < 0.05), gastric antrum (1.13 [0.37] vs. 1.47 [0.62], p < 0.05), and duodenal bulb (1.13 [0.34] vs. 1.33 [0.56], p < 0.05). In distal duodenum, though visibility improved with NAC with simethicone, the difference was insignificant. There were no adverse events related to the pre-endoscopy drink. Conclusion A pre-endoscopy drink of NAC with simethicone can significantly improve mucosal visibility during UGIE. It is safe, cheap, easily available and maybe considered for routine utilization for ensuring optimal endoscopic outcomes.

scholarly journals Aspiration in the Context of Upper Gastrointestinal Endoscopy

2007 ◽  
Vol 21 (4) ◽  
pp. 223-225 ◽  
Author(s):  
A Thomson ◽  
J Tye-Din ◽  
S Tonga ◽  
J Scott ◽  
C Mclaren ◽  
...  
Keyword(s):  
Pilot Study ◽  
Gastrointestinal Endoscopy ◽  
Pulmonary Aspiration ◽  
Upper Gastrointestinal Endoscopy ◽  
Life Threatening ◽  
The Mean ◽  
Clinically Significant ◽  
Upper Gastrointestinal ◽  
Nuclear Scanning ◽  
Present Pilot Study

BACKGROUND: Pulmonary aspiration is a life-threatening complication of upper gastrointestinal endoscopy, the incidence of which has not been determined. Endoscopy-related aspiration has not been studied in procedures in which patients swallow a radiolabelled potential aspirate immediately before endoscopy and undergo nuclear scanning postprocedure.METHODS: A pilot study was conducted in which 200 MBq of non-absorbable technetium-99m phytate in 10 mL of water was administered orally to 50 patients who were about to undergo endoscopy. Gamma camera images were obtained to ensure that there had been no aspiration before endoscopy. After endoscopy, a repeat scan was performed. Fluid aspirated through the endoscope was also collected and analyzed for radioactivity using a hand-held radiation monitor.RESULTS: No evidence of pulmonary aspiration was found in any of the patients studied. The mean estimated percentage of the initially administered radioactivity aspirated through the endoscope was 2.66% (range 0% to 10.3%).CONCLUSION: The present pilot study confirms earlier observations that clinically significant aspiration in the context of upper gastrointestinal endoscopy is uncommon. The incidence of aspiration may, however, be different in acutely bleeding patients undergoing endoscopy. For logistic reasons, this group could not be studied.

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