scholarly journals Doxorubicin Anticancer Drug Monitoring by ds-DNA-Based Electrochemical Biosensor in Clinical Samples

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 808
Author(s):  
Firouzeh Hassani Moghadam ◽  
Mohammad A. Taher ◽  
Hassan Karimi-Maleh
Keyword(s):  
Carbon Nanotubes ◽  
Detection Limit ◽  
Electrochemical Biosensor ◽  
Docking Study ◽  
Single Wall Carbon Nanotubes ◽  
Clinical Samples ◽  
Carbon Electrode ◽  
Molecular Docking Study ◽  
Voltammetric Sensing

In this research, glassy carbon electrode (GCE) amplified with single-wall carbon nanotubes (SWCNTs) and ds-DNA was fabricated and utilized for voltammetric sensing of doxorubicin with a low detection limit. In this technique, the reduction in guanine signal of ds-DNA in the presence of doxorubicin (DOX) was chosen as an analytical factor. The molecular docking study revealed that the doxorubicin drug interacted with DNA through intercalation mode, which was in agreement with obtained experimental results. The DOX detection performance of ds-DNA/SWCNTs/GCE was assessed at a concentration range of 1.0 nM–20.0 µM. The detection limit was found to be 0.6 nM that was comparable and even better (in many cases) than that of previous electrochemical reported sensors. In the final step, the ds-DNA/SWCNTs/GCE showed powerful ability for determination of the DOX in injection samples with acceptable recovery data.

A novel modified electrode based on terbium oxide and carbon nanotubes for the simultaneous determination of methyldopa and paracetamol

2016 ◽  
Vol 8 (23) ◽  
pp. 4711-4719 ◽  
Author(s):  
Aysegul Kutluay Baytak ◽  
Sehriban Duzmen ◽  
Tugce Teker ◽  
Mehmet Aslanoglu
Keyword(s):  
Carbon Nanotubes ◽  
Simultaneous Determination ◽  
Glassy Carbon Electrode ◽  
Modified Electrode ◽  
Glassy Carbon ◽  
Carbon Electrode ◽  
Terbium Oxide ◽  
Sensing Platform ◽  
Voltammetric Sensing

A novel voltammetric sensing platform was prepared ultrasonically by modifying a glassy carbon electrode (GCE) with a composite of terbium oxide (Tb4O7NPs) nanoparticles and carbon nanotubes (CNTs) for the simultaneous determination of methyldopa (MD) and paracetamol (PR).

scholarly journals Determination of Phenol and Chlorophenols at Single-Wall Carbon Nanotubes/Poly(3,4-ethylenedioxythiophene) Modified Glassy Carbon Electrode Using Flow Injection Amperometry

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Negussie Negash ◽  
Hailemichael Alemu ◽  
Merid Tessema
Keyword(s):  
Carbon Nanotubes ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Flow Injection ◽  
Analytical Performance ◽  
Single Wall Carbon Nanotubes ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Single Wall Carbon

Phenol and chlorophenols were investigated using single-wall carbon nanotubes (SWCNT) and poly(3,4-ethylenedioxythiophene) (PEDOT) composite modified glassy carbon electrode (SWCNT/PEDOT/GCE) as a detector in flow injection system. Optimization of experimental variables such as the detection potential, flow rate, and pH of the carrier solution (0.1 M sodium acetate) for the determination of phenol (P), 4-chlorophenol (CP), 2,4-dichlorophenol (DCP), 2,4,6-trichlorophenol (TCP), and pentachlorophenol (PCP) were performed. Under these conditions, analytical parameters were calculated from the calibration curve of measured amperometric responses as a function of concentrations of phenol and chlorophenols. The designed electrode exhibited very good analytical performance. The designed electrode was tested with 20 repetitive injections of each analyte and showed good operational stability. The analytical performance of the SWCNT/PEDOT/GCE electrode under flow through conditions was tested and was found to be impressive. The electrode showed a wider dynamic range for the detection of phenol and chlorophenols with low limits of detection compared with other enzymatic and nonenzymatic sensors. These results suggest that the method is quite useful for the analysis and monitoring of phenols and chlorophenols.

Molecularly Imprinted Electrochemical Sensor for the Determination of Sulfamethoxazole

2018 ◽  
Vol 21 (2) ◽  
pp. 077-080 ◽  
Author(s):  
Benzhi Liu ◽  
Guangqing Liu ◽  
Bo Xiao ◽  
Jinlong Yan
Keyword(s):  
Carbon Nanotubes ◽  
Detection Limit ◽  
Electrochemical Sensor ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Molecularly Imprinted ◽  
Real Samples ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

A selective and sensitive molecularly imprinted electrochemical sensor was prepared based on the electropolymerization of methylthionine chloride on the multi-walled carbon nanotubes modified glassy carbon electrode. The proposed sensor was applied to the determination of sulfamethoxazole which showed a linear range of 2.4 to 23.6 µM, and a detection limit of 0.81 µM.The determination of sulfamethoxazole in real samples was also studied.

A novel label free long non-coding RNA electrochemical biosensor based on green l-cysteine electrodeposition and Au–Rh hollow nanospheres as tags

RSC Advances ◽  
2015 ◽  
Vol 5 (64) ◽  
pp. 51990-51999 ◽  
Author(s):  
Fei Liu ◽  
Guiming Xiang ◽  
Liqun Zhang ◽  
Dongneng Jiang ◽  
Linlin Liu ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Signal Amplification ◽  
Electrochemical Biosensor ◽  
Single Wall Carbon Nanotubes ◽  
Complex Signal ◽  
Ultrasensitive Detection ◽  
Label Free ◽  
Hollow Nanospheres ◽  
Non Coding Rna ◽  
Long Non Coding Rna

lncRNA biosensor based on single-wall carbon nanotubes wrapped with Au–Rh hollow nanospheres (Au/Rh-HNP@SWCNT) complex signal amplification and an l-Cys Au nano-film provided ultrasensitive detection for the nuclear paraspeckle assembly transcript 1 (NEAT1).

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