scholarly journals Molecular Epidemiology of Vancomycin-Resistant Enterococci Bloodstream Infections in Germany: A Population-Based Prospective Longitudinal Study

2022 ◽  
Vol 10 (1) ◽  
pp. 130
Author(s):  
Carlos L. Correa-Martínez ◽  
Annette Jurke ◽  
Janne Schmitz ◽  
Frieder Schaumburg ◽  
Stefanie Kampmeier ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Demographic Data ◽  
Bloodstream Infections ◽  
Population Based ◽  
Federal State ◽  
Glycopeptide Resistance ◽  
Prospective Longitudinal Study ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant ◽  
Prospective Longitudinal

Vancomycin-resistant enterococci (VRE) pose a public health challenge worldwide. While VRE bloodstream infections (VREBI) increase in Germany and Europe, population-based molecular data are scarce. We aimed to analyze the molecular epidemiology, demographic aspects, and geographical distribution of VREBI in the German Federal State of North-Rhine–Westphalia (NRW), located in the German–Dutch–Belgian border area, representing over 20% of Germany’s population. VREBI isolates were collected from hospitals across NRW between 2016 and 2019. Demographic data were gathered and anonymized upon sample collection. Multilocus sequence typing (MLST) and identification of glycopeptide resistance were carried out. Epidemiological analysis and geographical mapping were performed. Single VREBI isolates from 755 patients were analyzed. In total, 38.9% were female, and 80.0% were aged ≥ 60 years. The VREBI incidence per 100,000 inhabitants nearly tripled, from 0.52 (2016) to 1.48 (2019), particularly in male patients aged ≥ 50 years. The proportion of vanB reached 83% (n = 202/243) in 2018, overtaking vanA as the predominant glycopeptide resistance determinant, detected in close relation with ST117 isolates. The proportion of MLST sequence type (ST) 117 peaked in 2018, at 78.2% (n = 190/243). The major role of these emerging strains in invasive infections in central Europe requires novel strategies for their diagnosis, treatment, and prevention.

Molecular epidemiology of vancomycin-resistant enterococci in Singapore

Pathology ◽  
2009 ◽  
pp. 1-5
Author(s):  
Tse Koh ◽  
Beng Low ◽  
Nicholas Leo ◽  
Li-Yang Hsu ◽  
Raymond Lin ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant

Molecular epidemiology of vancomycin–resistant enterococci in Singapore

Pathology ◽  
2009 ◽  
Vol 41 (7) ◽  
pp. 676-680 ◽  
Author(s):  
Tse H. Koh ◽  
Beng S. Low ◽  
Nicholas Leo ◽  
Li-Yang Hsu ◽  
Raymond T.P. Lin ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant

scholarly journals Efficacy of betadine vaginal toileting before caesarean section in postoperative infections

2020 ◽  
Vol 9 (6) ◽  
pp. 2457
Author(s):  
Tarang Preet Kaur ◽  
Asmita M. Rathore ◽  
Latika Sahu
Keyword(s):  
Caesarean Section ◽  
Postoperative Morbidity ◽  
Placenta Previa ◽  
Demographic Data ◽  
Febrile Illness ◽  
Wound Sepsis ◽  
Prospective Longitudinal Study ◽  
Group 2 ◽  
Foley’S Catheter ◽  
Prospective Longitudinal

Background: The objective of the current study was to evaluate the efficacy of preoperative betadine vaginal toileting in reducing post caesarean infections (endometritis, febrile illness, wound sepsis).Methods: This prospective longitudinal study was conducted at Maulana Azad Medical College, New Delhi over 3 months among 200 women who underwent caesarean delivery. Inclusion criteria were defined as women undergoing caesarean section. Exclusion criteria included placenta previa, active genital herpes, cord prolapse, chorioamnionitis, allergy to iodine. After taking informed consent, subjects were divided into two groups by simple randomization method using computer generated random numbers- Group 1 (case) - subjects who underwent 5% povidone iodine sponge stick cleansing in all the fornices and walls of vagina for 30 seconds after foley’s catheter insertion and before abdominal scrubbing. Group 2 (control) - subjects who didn't receive betadine vaginal toileting before caesarean section Subjects were followed for 10 days postpartum (or till suture removal/ discharge from hospital, whichever was late). Demographic data, operative details and postoperative parameters were compared between the two groups.Results: Both groups were matched for baseline patients’ characteristics (age, BMI, gestational age, operative time). Women who received preoperative betadine vaginal toileting had markedly less incidence of endometritis (case-3%, control-10%, p<0.05), overall postoperative morbidity (case-13%, control-33%, p<0.001). Incidence of postoperative febrile illness (case-6%, control-12%, p>0.05) and wound sepsis (case-5%, control-12%, p>0.05) were found to be less but not significant between both groups.Conclusions: Preoperative vaginal cleansing helps in reducing postoperative morbidity by decreasing incidence of postoperative infection.

scholarly journals Vancomycin-Resistant Enterococci from Humans and Retail Chickens in Taiwan with Unique VanB Phenotype-vanA Genotype Incongruence

2002 ◽  
Vol 46 (2) ◽  
pp. 525-527 ◽  
Author(s):  
Tsai-Ling Lauderdale ◽  
L. Clifford McDonald ◽  
Yih-Ru Shiau ◽  
Pei-Chen Chen ◽  
Hui-Yin Wang ◽  
...  
Keyword(s):  
Glycopeptide Resistance ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant

ABSTRACT Vancomycin resistant enterococci (VRE) with VanB phenotype-vanA genotype incongruence were found in all 39 VRE isolated from chicken carcasses and four human VRE isolates in Taiwan. Three identical mutations in the vanS gene were found in the VanB phenotype-vanA genotype VRE sequenced. This finding indicates possible transmission of glycopeptide resistance among different hosts.

scholarly journals Oritavancin Activity against Vancomycin-Susceptible and Vancomycin-Resistant Enterococci with Molecularly Characterized Glycopeptide Resistance Genes Recovered from Bacteremic Patients, 2009-2010

2011 ◽  
Vol 56 (3) ◽  
pp. 1639-1642 ◽  
Author(s):  
Rodrigo E. Mendes ◽  
Leah N. Woosley ◽  
David J. Farrell ◽  
Helio S. Sader ◽  
Ronald N. Jones
Keyword(s):  
Resistance Genes ◽  
Glycopeptide Resistance ◽  
Content Type ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant

ABSTRACTOritavancin exhibited potent activity against vancomycin-susceptible (MIC50and MIC90, 0.015/0.03 μg/ml) andvanB-carryingE. faecalisisolates (MIC50and MIC90, 0.015 and 0.015 μg/ml). Higher (16- to 32-fold) MIC50s and MIC90s forvanA-harboringE. faecaliswere noted (MIC50and MIC90, 0.25 and 0.5 μg/ml), although oritavancin inhibited all strains at ≤0.5 μg/ml. Vancomycin-susceptible andvanB-carryingE. faeciumstrains (MIC50and MIC90, ≤0.008 and ≤0.008 μg/ml for both) were very susceptible to oritavancin, as were VanA-producing isolates (MIC50and MIC90, 0.03 and 0.06 μg/ml). Oritavancin exhibited goodin vitropotency against this collection of organisms, including vancomycin-resistant enterococci.

Enterokokken mit speziellen Resistenzen – Epidemiologie, Hygiene und Therapie

2019 ◽  
Vol 144 (08) ◽  
pp. 553-560 ◽  
Author(s):  
Alexander Mischnik ◽  
Guido Werner ◽  
Jennifer Bender ◽  
Nico Mutters
Keyword(s):  
Scientific Evidence ◽  
Bloodstream Infections ◽  
Multidrug Resistant ◽  
Vancomycin Resistant Enterococci ◽  
Resistance Patterns ◽  
Single Intervention ◽  
Vancomycin Resistant ◽  
Meta Analyses ◽  
Resistance Rates ◽  
Insight Into

AbstractEnterococci with special resistance patterns (mainly vancomycin-resistant enterococci) play an important role in everyday clinical practice. Rising resistance rates to linezolid, daptomycin or tigecycline are also increasingly reported. Therapeutically, linezolid and daptomycin are the most important substances mainly in infections due to vancomycin-resistant enterococci. Several systematic meta-analyses of bloodstream infections showed discrepant results in the comparison of mortality of linezolid and daptomycin-treated bacteraemias. The containment of enterococci with special resistance patterns is currently receiving great attention. The key hygienic issue in all recommendations for dealing with multidrug-resistant enterococci can be summarized very simply: current scientific evidence is often inconsistent and studies that have clearly tested a single intervention for efficacy are lacking. The present work gives an insight into the current epidemiology and therapeutic strategies. Furthermore, the recently published German KRINKO recommendations are presented.

A change in the molecular epidemiology of vancomycin resistant enterococci in Western Australia

Pathology ◽  
2014 ◽  
Vol 46 (1) ◽  
pp. 73-75 ◽  
Author(s):  
Geoffrey W. Coombs ◽  
Denise Daley ◽  
Julie C. Pearson ◽  
Paul R. Ingram
Keyword(s):  
Molecular Epidemiology ◽  
Western Australia ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant

scholarly journals Sibling Bullying: A Prospective Longitudinal Study of Associations with Positive and Negative Mental Health during Adolescence

2021 ◽  
Author(s):  
Umar Toseeb ◽  
Dieter Wolke
Keyword(s):  
Mental Health ◽  
Health Outcomes ◽  
Early Adolescence ◽  
Developmental Trajectories ◽  
Late Adolescence ◽  
Population Based ◽  
Poor Mental Health ◽  
Mental Health Outcomes ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

AbstractSibling bullying is associated with poor mental health outcomes, but the relevance of specific bullying roles remains unclear. Data from a population-based study (n = 17,157, 48% female) focusing on early (11 years), middle (14 years), and late (17 years) adolescence were analyzed. Associations between sibling bullying roles in early adolescence and positive and negative mental health outcomes in late adolescence were investigated. Generally, bullying, irrespective of role, was associated with poorer mental health outcomes in late adolescence. As the frequency of bullying victimization increased between early and middle adolescence so did the severity of mental health outcomes in late adolescence. The developmental trajectories of externalizing problems were influenced by bullying in early adolescence. Sibling bullying, irrespective of role, is associated with poor mental health outcomes.

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