scholarly journals The Janus Face of PAMAM Dendrimers Used to Potentially Cure Nonenzymatic Modifications of Biomacromolecules in Metabolic Disorders—A Critical Review of the Pros and Cons

Molecules ◽  
2013 ◽  
Vol 18 (11) ◽  
pp. 13769-13811 ◽  
Author(s):  
Magdalena Labieniec-Watala ◽  
Kamil Karolczak ◽  
Karolina Siewiera ◽  
Cezary Watala
2020 ◽  
Vol 26 ◽  
Author(s):  
Sridevi Vaadala ◽  
Naveen Ponneri ◽  
Venkat Shashank Karnam ◽  
Ramachandra Reddy Pamuru ◽  
Mohammed Arifullah

Background: Phytoestrogens are non-endocrine, non-steroidal secondary derivatives of plants and consumed through plant-based diet also named as “dietary estrogens”. The major sources of phytoestrogens are soy and soy-based foods, flax seed, chickpeas, green beans, dairy products, etc. The dietary inclusion of phytoestrogen based foods play a crucial role in the maintenance of metabolic syndrome cluster including obesity, diabetes, blood pressure, cancer, inflammation, cardiovascular diseases, postmenopausal ailments and their complications. In recent days, phytoestrogens are the preferred molecules for hormone replacement therapy. On the other hand, they act as endocrine disruptors via estrogen receptor mediated pathways. These effects are not restricted to adult males or females and identified even in development. Objective: Since phytoestrogenic occurrence is high at daily meal for most people from all over the world, they focused to study for its beneficiary effects towards developing pharmaceutical drugs for treating various metabolic disorders by keeping an eye on endocrine disruption. Conclusion: The present review emphasizes the pros and cons of phytoestrogens on human health, which may help to direct the pharmaceutical industry to produce various phytoestrongen based drugs against various metabolic disorders.


2020 ◽  
Vol 17 (9) ◽  
pp. 4167-4171
Author(s):  
Mausumi Goswami ◽  
M. Niranjanamurthy ◽  
Anlin Assisi ◽  
Sanjana Pillai ◽  
Christy Sunny ◽  
...  

Unstructured data is outcome of various major business applications. Summarizing unstructured data is considered as a significant task in this era of smart digital evolution. Text summarization is basically done using the common approaches on the basis of certain predefined rules. Text summarization is a branch of text mining which helps in bringing together the main content of the text from the original text or document. This work was an attempt to understand the existing literature and make a critical review on the pros and cons of the methods used. A gap analysis is also included after inspecting various methods. A comparative study of intrinsic and extrinsic evaluation techniques is included. A methodology is proposed for text summarization using machine learning.


Author(s):  
Hong Yang ◽  
Lingling Chen ◽  
Qian Sun ◽  
Fangyao Yao ◽  
Saeed Muhammad ◽  
...  

Author(s):  
Ehsan Malekipour ◽  
Hazim El-Mounayri

Abstract The powder-bed fusion (PBF) process is capable of producing near-fully dense metallic parts; however, various defects — particularly thermal abnormalities — can still be observed during the process. Some of these thermal defects — cracks, distortion, delamination of layers, and microporosity — cannot be removed by post-processing operations. The majority of these abnormalities are the result of residual stress, heat accumulation, lack of inter-track /inter-layer bonding, lack of powder fusion, or a combination of these factors. Modifying the scanning strategy (the topology of scanning tracks) can efficiently mitigate these abnormalities by adjusting the process parameters and adopting proper scanning patterns. The implementation of different scanning strategies significantly changes the ultimate quality of printed parts and manufacturing process lead time. Choosing a proper scanning strategy minimizes the residual stress and internal porosity, generates homogeneous microstructure, and avoids heat accumulation throughout the part during the printing process. In this work, we conducted a critical review of different scanning strategies, their pros and cons, limitations, and influence on the resulting properties of fabricated parts. Furthermore, we report the latest efforts for improvement of the current scanning strategies and introduce the-state-of-the-art strategies in the multi-laser PBF (ML-PBF) process. The insights provided here can assist scholars in evaluating existing scanning strategies and scanning patterns, and in identifying ways both to overcome scanning limitations and to modify them. On the other hand, it can assist manufacturers in selecting the best scanning strategies for their products based on their designs, demands, and resources.


2017 ◽  
Vol 237 (3) ◽  
pp. 163-189 ◽  
Author(s):  
Margit Schratzenstaller ◽  
Alexander Krenek ◽  
Danuše Nerudová ◽  
Marian Dobranschi

Abstract EU taxes play a key role in political and economic discussions about the future of the EU own resource system, and their desirability can vary accordingly. It is therefore essential to clearly articulate the goals which are to be achieved by the introduction of this new financing tool. This paper provides a critical review of pros and cons of EU taxes put forward in the literature. Reviewing the conventional fiscal federalism and political economy literature on this topic it can be concluded that there is no convincing (overall) case for funding the EU budget with EU taxes rather than with contributions by Member States which currently make up for the lion’s share of EU own resources. There are, however, some specific issues arising from a sustainability perspective, which could be addressed with the introduction of EU taxes. Departing from a comprehensive concept of sustainability which is based on the economic, the social, the environmental and the cultural/institutional pillar of sustainability, the paper identifies existing sustainability gaps in taxation in the EU. EU taxes if designed accordingly may be suitable instruments to reduce these sustainability gaps and thus to strengthen sustainability-orientation of taxation in the EU.


RSC Advances ◽  
2014 ◽  
Vol 4 (48) ◽  
pp. 25310-25318 ◽  
Author(s):  
Zea Strassberger ◽  
Stefania Tanase ◽  
Gadi Rothenberg

Wood to chemicals is the subject of this short critical review, that outlines the chemical and economic aspects of several short-term and long-term perspectives for the valorisation of lignin to aromatics, polymers and materials.


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