Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (1H and 13C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32–128 µg/mL; 0.145–0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).

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Antibacterial activity of Taxodium ascendens Diterpenes against Methicillin-resistant Staphylococcus aureus

Natural Product Communications ◽

10.1177/1934578x1400900817 ◽

2014 ◽

Vol 9 (8) ◽

pp. 1934578X1400900 ◽

Cited By ~ 2

Author(s):

Courtney M. Starks ◽

Vanessa L. Norman ◽

Russell B. Williams ◽

Matt G. Goering ◽

Stephanie M. Rice ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Antibacterial Activity ◽

Bacterial Infections ◽

Methicillin Resistant Staphylococcus Aureus ◽

Clinical Isolates ◽

Drug Resistant ◽

Methicillin Resistant

One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens. Of these, demethylcryptojaponol (2), 6-hydroxysalvinolone (3), hydroxyferruginol (4), and hinokiol (5) demonstrated potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). These compounds represent a class of synthetically accessible compounds that could be further developed for treatment of drug-resistant bacterial infections.

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Antibacterial Activity and Mechanism of Action of Aspidinol Against Multi-Drug-Resistant Methicillin-Resistant Staphylococcus aureus

Frontiers in Pharmacology ◽

10.3389/fphar.2018.00619 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 5

Author(s):

Xin Hua ◽

Qin Yang ◽

Wanjiang Zhang ◽

Zhimin Dong ◽

Shenye Yu ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Antibacterial Activity ◽

Mechanism Of Action ◽

Methicillin Resistant Staphylococcus Aureus ◽

Drug Resistant ◽

Methicillin Resistant

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Antibacterial Activity of BSA-Capped Gold Nanoclusters against Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Intermediate Staphylococcus aureus (VISA)

Journal of Nanomaterials ◽

10.1155/2019/4101293 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Shu-Hua Kuo ◽

Chi-Sheng Chien ◽

Chun-Chi Wang ◽

Chi-Jen Shih

Keyword(s):

Staphylococcus Aureus ◽

Antibacterial Activity ◽

Bovine Serum Albumin ◽

Serum Albumin ◽

Bovine Serum ◽

Methicillin Resistant Staphylococcus Aureus ◽

Gold Nanoclusters ◽

Drug Resistant ◽

Fluorescence Image ◽

Methicillin Resistant

The emergence of drug-resistant pathogens and the abuse of antibiotics have posed dominant threats to society. In this study, we propose an antibacterial use of bovine serum albumin-capped gold nanoclusters (BSA-AuNCs) to address the issue. BSA-AuNCs have a great antibacterial activity against MRSA and VISA which is proved by time-killing curves (TKC). The possible antibacterial mechanisms of BSA-AuNCs against MRSA and VISA are confirmed by fluorescence image observation.

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