Serum N-Glycosylation in Parkinson’s Disease: A Novel Approach for Potential Alterations

In this study, we present the application of a novel capillary electrophoresis (CE) method in combination with label-free quantitation and support vector machine-based feature selection (support vector machine-estimated recursive feature elimination or SVM-RFE) to identify potential glycan alterations in Parkinson’s disease. Specific focus was placed on the use of neutral coated capillaries, by a dynamic capillary coating strategy, to ensure stable and repeatable separations without the need of non-mass spectrometry (MS) friendly additives within the separation electrolyte. The developed online dynamic coating strategy was applied to identify serum N-glycosylation by CE-MS/MS in combination with exoglycosidase sequencing. The annotated structures were quantified in 15 controls and 15 Parkinson’s disease patients by label-free quantitation. Lower sialylation and increased fucosylation were found in Parkinson’s disease patients on tri-antennary glycans with 2 and 3 terminal sialic acids. The set of potential glycan alterations was narrowed by a recursive feature elimination algorithm resulting in the efficient classification of male patients.

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Using Artificial Neural Network to Discriminate Parkinson’s Disease from Other Parkinsonisms by Focusing on Putamen of Dopamine Transporter SPECT Images

Biomedicines ◽

10.3390/biomedicines9010012 ◽

2020 ◽

Vol 9 (1) ◽

pp. 12

Author(s):

Chung-Yao Chien ◽

Szu-Wei Hsu ◽

Tsung-Lin Lee ◽

Pi-Shan Sung ◽

Chou-Ching Lin

Keyword(s):

Neural Network ◽

Parkinson’S Disease ◽

Artificial Neural Network ◽

Support Vector Machine ◽

Parkinson's Disease ◽

Dopamine Transporter ◽

Support Vector ◽

Dat Spect ◽

Ann Classifier ◽

Spect Images

Background: The challenge of differentiating, at an early stage, Parkinson’s disease from parkinsonism caused by other disorders remains unsolved. We proposed using an artificial neural network (ANN) to process images of dopamine transporter single-photon emission computed tomography (DAT-SPECT). Methods: Abnormal DAT-SPECT images of subjects with Parkinson’s disease and parkinsonism caused by other disorders were divided into training and test sets. Striatal regions of the images were segmented by using an active contour model and were used as the data to perform transfer learning on a pre-trained ANN to discriminate Parkinson’s disease from parkinsonism caused by other disorders. A support vector machine trained using parameters of semi-quantitative measurements including specific binding ratio and asymmetry index was used for comparison. Results: The predictive accuracy of the ANN classifier (86%) was higher than that of the support vector machine classifier (68%). The sensitivity and specificity of the ANN classifier in predicting Parkinson’s disease were 81.8% and 88.6%, respectively. Conclusions: The ANN classifier outperformed classical biomarkers in differentiating Parkinson’s disease from parkinsonism caused by other disorders. This classifier can be readily included into standalone computer software for clinical application.

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Diagnosis of Parkinson's disease using genetic algorithm and support vector machine with acoustic characteristics

2012 5th International Conference on BioMedical Engineering and Informatics ◽

10.1109/bmei.2012.6513201 ◽

2012 ◽

Cited By ~ 2

Author(s):

Hanguang Xiao

Keyword(s):

Genetic Algorithm ◽

Parkinson’S Disease ◽

Support Vector Machine ◽

Parkinson's Disease ◽

Support Vector ◽

Acoustic Characteristics

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Tremor Identification Using Machine Learning in Parkinson's Disease

Early Detection of Neurological Disorders Using Machine Learning Systems - Advances in Medical Technologies and Clinical Practice ◽

10.4018/978-1-5225-8567-1.ch008 ◽

2019 ◽

pp. 128-151

Author(s):

Angana Saikia ◽

Vinayak Majhi ◽

Masaraf Hussain ◽

Sudip Paul ◽

Amitava Datta

Keyword(s):

Machine Learning ◽

Parkinson’S Disease ◽

Support Vector Machine ◽

Parkinson's Disease ◽

Discriminant Analysis ◽

Learning Algorithms ◽

The Body ◽

Machine Learning Algorithms ◽

Support Vector

Tremor is an involuntary quivering movement or shake. Characteristically occurring at rest, the classic slow, rhythmic tremor of Parkinson's disease (PD) typically starts in one hand, foot, or leg and can eventually affect both sides of the body. The resting tremor of PD can also occur in the jaw, chin, mouth, or tongue. Loss of dopamine leads to the symptoms of Parkinson's disease and may include a tremor. For some people, a tremor might be the first symptom of PD. Various studies have proposed measurable technologies and the analysis of the characteristics of Parkinsonian tremors using different techniques. Various machine-learning algorithms such as a support vector machine (SVM) with three kernels, a discriminant analysis, a random forest, and a kNN algorithm are also used to classify and identify various kinds of tremors. This chapter focuses on an in-depth review on identification and classification of various Parkinsonian tremors using machine learning algorithms.

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