scholarly journals Cholinergic Chemotransmission and Anesthetic Drug Effects at the Carotid Bodies

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5974
Author(s):  
Maarten Honing ◽  
Chris Martini ◽  
Monique van Velzen ◽  
Marieke Niesters ◽  
Albert Dahan ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Muscle Relaxation ◽  
Drug Effects ◽  
Muscle Relaxants ◽  
Control Of Breathing ◽  
Loss Of Consciousness ◽  
Anesthetic Drug ◽  
Carotid Bodies ◽  
Peripheral Chemoreflex

General anesthesia is obtained by administration of potent hypnotics, analgesics and muscle relaxants. Apart from their intended effects (loss of consciousness, pain relief and muscle relaxation), these agents profoundly affect the control of breathing, in part by an effect within the peripheral chemoreflex loop that originates at the carotid bodies. This review assesses the role of cholinergic chemotransmission in the peripheral chemoreflex loop and the mechanisms through which muscle relaxants and hypnotics interfere with peripheral chemosensitivity. Additionally, consequences for clinical practice are discussed.

Changing the prescription status of physiotherapists: Perception of Nigerian physiotherapists

2013 ◽  
Author(s):  
Ayodele T Onigbinde ◽  
Adebiyi S Adereni ◽  
Kayode DS Bamitale ◽  
Sylvia VK Kambalametore ◽  
Vyvienne M’kumbuzi ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Global Change ◽  
Muscle Relaxants ◽  
Descriptive Statistics ◽  
Moderate Number ◽  
Image Improvement ◽  
Self Administered Questionnaire ◽  
Prescription Status

Background: There appears to be a global change in the role of physiotherapists (most especially) in serving as supplementary prescribers of relevant drugs.Objectives: This study aimed to determine the opinion of physiotherapists on enlistment as supplementary prescribers of drugs, and the classes of drugs they would like to prescribe.Methods: 102 licensed physiotherapists from 5 purposively selected hospitals participated in the study. A self administered questionnaire was used to collect the data. Data were analyzed using descriptive statistics and Kruskal Wallis test.Results: Eighty-three physiotherapists (83.8%) wanted to be enlisted as supplementary prescribers and most would like to prescribe analgesics (74.8%), NSAIDS (74.8%) and muscle relaxants (59.2%). Also, 89 respondents (86.4%) supported the enactment of a law that will protect physiotherapists in case of professional litigation. A range of reasons were adduced for desiring to have a change in prescription status and these include effectiveness of clinical practice (77.7%), image improvement (67.0%) and the increased benefit for patients (82.5%). The number of respondents who would like to prescribe Analgesics, NSAIDS and Muscle relaxants were significantly higher than for other classes of drugs (P = 0.001). It was concluded that the majority of physiotherapists would want their status to change to that of supplementary prescribers. Also, most prescribers would like to prescribe analgesics and NSAIDS while a moderate number would like to prescribe muscle relaxants under the protection of an enabling law.

scholarly journals Computer Controlled Muscle Relaxation: A Comparison of Four Muscle Relaxants in the Sheep

1976 ◽  
Vol 4 (1) ◽  
pp. 16-22 ◽  
Author(s):  
N. M. Cass ◽  
D. G. Lampard ◽  
W. A. Brown ◽  
J. R. Coles
Keyword(s):  
Clinical Practice ◽  
Muscle Relaxant ◽  
Muscle Relaxation ◽  
Computer Control ◽  
Muscle Relaxants ◽  
Muscle Paralysis ◽  
Precise Control ◽  
Integrated Electromyogram ◽  
Computer Controlled

Computer control of anaesthesia has been extended to include muscle relaxant drugs. Injection of d-tubocurarine, gallamine, alcuronium or pancuronium was controlled by computer to reduce the integrated electromyogram to a preset level (40 per cent of control) for one hour. A programmed level of muscle paralysis is therefore possible for use in physiological and pharmacological experiments, and in clinical practice where precise control of the degree of paralysis together with minimal dosage is advantageous.

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Diseases ◽  
Hepatic Disease ◽  
Noninvasive Detection ◽  
Diagnosis And Prognosis ◽  
Expected Performance ◽  
Potential Biomarker ◽  
Disease Condition ◽  
Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Enhancing clinical practice: The role of practice guidelines.

1994 ◽  
Vol 49 (1) ◽  
pp. 30-33 ◽  
Author(s):  
J. Jarrett Clinton ◽  
Kathleen McCormick ◽  
Jacqueline Besteman
Keyword(s):  
Clinical Practice ◽  
Practice Guidelines

Man am I Stoned, I think! The role of experience and side effects in the perception of drug effects

1972 ◽  
Author(s):  
Cornelis Bakker ◽  
Albert S. Carlin ◽  
Robert Heaton ◽  
Reese T. Jones ◽  
Theodore X. Barber
Keyword(s):  
Side Effects ◽  
Drug Effects

Role of niacin in current clinical practice

2019 ◽  
Vol 110 (1) ◽  
Author(s):  
Abhishek Sharma ◽  
Nidhi Madan
Keyword(s):  
Clinical Practice ◽  
Current Clinical Practice

THE ROLE OF EBM AND CLINICAL PRACTICE GUIDELINES IN GENERATING RESEARCH AND INTERVENTIONS IN NEGLECTED TROPICAL DISEASES: A RATIONAL MODEL FOR DEVELOPING COUNTRIES

2020 ◽  
Author(s):  
Cristhian David Morales-Plaza
Keyword(s):  
Developing Countries ◽  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Neglected Tropical Diseases ◽  
Tropical Diseases ◽  
Rational Model ◽  
Clinical Practices ◽  
Vulnerable Communities

Guarantee better clinical practices among clinicians who attend NTDs in developing countries as well as provide education in vector control in hotspot vulnerable communities

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