scholarly journals Crocins, the Bioactive Components of Crocus sativus L., Counteract the Disrupting Effects of Anesthetic Ketamine on Memory in Rats

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 528
Author(s):  
Nikolaos Pitsikas ◽  
Petros A. Tarantilis
Keyword(s):  
Recognition Memory ◽  
Memory Deficits ◽  
Nmda Receptor Antagonist ◽  
Crocus Sativus ◽  
Bioactive Components ◽  
Memory Impairments ◽  
Bioactive Ingredients ◽  
Behavioral Memory ◽  
Spatial Recognition ◽  
Crocus Sativus L

Consistent experimental evidence suggests that anesthetic doses of the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist ketamine cause severe memory impairments in rodents. Crocins are among the various bioactive ingredients of the plant Crocus sativus L., and their implication in memory is well-documented. It has not yet been elucidated if crocins are able to attenuate the memory deficits produced by anesthetic ketamine. The present study was undertaken aiming to clarify this issue in the rat. For this aim, the object recognition, the object location and the habituation tests, reflecting non-spatial recognition memory, spatial recognition memory and associative memory, respectively, were utilized. A post-training challenge with crocins (15–30 mg/kg, intraperitoneally (i.p.), acutely) counteracted anesthetic ketamine (100 mg/kg, i.p.)-induced performance impairments in all the above-mentioned behavioral memory paradigms. The current findings suggest that crocins modulate anesthetic ketamine’s amnestic effects.

scholarly journals Crocus sativus L. Extracts and Its Constituents Crocins and Safranal; Potential Candidates for Schizophrenia Treatment?

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1237
Author(s):  
Nikolaos Pitsikas
Keyword(s):  
Antipsychotic Agents ◽  
Crocus Sativus ◽  
Current Therapy ◽  
Bioactive Components ◽  
Memory Problems ◽  
Beneficial Action ◽  
The Central Nervous System ◽  
Anxiety Depression ◽  
New Antipsychotics ◽  
Crocus Sativus L

Schizophrenia is a chronic mental devastating disease. Current therapy suffers from various limitations including low efficacy and serious side effects. Thus, there is an urgent necessity to develop new antipsychotics with higher efficacy and safety. The dried stigma of the plant Crocus sativus L., (CS) commonly known as saffron, are used in traditional medicine for various purposes. It has been demonstrated that saffron and its bioactive components crocins and safranal exert a beneficial action in different pathologies of the central nervous system such as anxiety, depression, epilepsy and memory problems. Recently, their role as potential antipsychotic agents is under investigation. In the present review, I intended to critically assess advances in research of these molecules for the treatment of schizophrenia, comment on their advantages over currently used neuroleptics as well-remaining challenges. Up to our days, few preclinical studies have been conducted to this end. In spite of it, results are encouraging and strongly corroborate that additional research is mandatory aiming to definitively establish a role for saffron and its bioactive components for the treatment of schizophrenia.

scholarly journals Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice

2020 ◽  
Vol 94 ◽  
pp. 281-286
Author(s):  
David V.C. Brito ◽  
Kubra Gulmez Karaca ◽  
Janina Kupke ◽  
Franziska Mudlaff ◽  
Benjamin Zeuch ◽  
...  
Keyword(s):  
Young Adult ◽  
Recognition Memory ◽  
Memory Impairments ◽  
Adult Mice ◽  
Spatial Recognition

scholarly journals Minocycline-induced microbiome alterations predict cafeteria diet-induced spatial recognition memory impairments in rats

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sarah-Jane Leigh ◽  
Nadeem O. Kaakoush ◽  
R. Frederick Westbrook ◽  
Margaret J. Morris
Keyword(s):  
Recognition Memory ◽  
Cafeteria Diet ◽  
Memory Impairments ◽  
Spatial Recognition

scholarly journals The GABAA-Benzodiazepine Receptor Antagonist Flumazenil Abolishes the Anxiolytic Effects of the Active Constituents of Crocus sativus L. Crocins in Rats

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5647
Author(s):  
Nikolaos Pitsikas ◽  
Petros A. Tarantilis
Keyword(s):  
Receptor Antagonist ◽  
Open Field ◽  
Field Tests ◽  
Benzodiazepine Receptor ◽  
Crocus Sativus ◽  
Acute Administration ◽  
Beneficial Effects ◽  
Bioactive Ingredients ◽  
Benzodiazepine Receptor Antagonist ◽  
Crocus Sativus L

Anxiety is a chronic severe psychiatric disorder. Crocins are among the various bioactive components of the plant Crocus sativus L. (Iridaceae) and their implication in anxiety is well-documented. However, which is the mechanism of action underlying the anti-anxiety effects of crocins remains unknown. In this context, it has been suggested that these beneficial effects might be ascribed to the agonistic properties of these bioactive ingredients of saffron on the GABA type A receptor. The current experimentation was undertaken to clarify this issue in the rat. For this research project, the light/dark and the open field tests were used. A single injection of crocins (50 mg/kg, i.p., 60 min before testing) induces an anti-anxiety-like effect revealed either in the light-dark or open field tests. Acute administration of the GABAA-benzodiazepine receptor antagonist flumazenil (10 mg/kg, i.p., 30 min before testing) abolished the above mentioned anxiolytic effects of crocins. The current findings suggest a functional interaction between crocins and the GABAA receptor allosteric modulator flumazenil on anxiety.

Dermoprotective effects of saffron: A mini review

2021 ◽  
Vol 27 ◽  
Author(s):  
Hamid Rigi ◽  
Leila Mohtashami ◽  
Maryam Asnaashari ◽  
Zahra Tayarani-Najaran
Keyword(s):  
Skin Diseases ◽  
Food Additive ◽  
Crocus Sativus ◽  
Chemical Components ◽  
Protective Effects ◽  
Memory Impairments ◽  
Anti Oxidant ◽  
Crocus Sativus L

: Crocus sativus L. (Iridaceae), known as saffron, is widely used as a coloring agent, food additive, and medicinal spice. Saffron can be beneficial for treating convulsions, tumors, oxidative-related diseases, inflammation, memory impairments, and depression. These effects are due to its chemical components like anthocyanins, flavonoids and terpenoids. Saffron has been shown to be of benefit for treating skin diseases as a result of its anti-oxidant, anti-microbial, depigmenting, and repairing activities. Therefore, it is used for formulating various lotions, creams, and cosmetics emulsions, namely sunscreens, moisturizers, and anti-spot and anti-aging products. In this review, we have presented various skin protective effects of saffron and its components.

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