scholarly journals Reusable Nano-Zirconia-Catalyzed Synthesis of Benzimidazoles and Their Antibacterial and Antifungal Activities

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4219
Author(s):  
Tentu Nageswara Rao ◽  
Suliman Yousef AlOmar ◽  
Faheem Ahmed ◽  
Fadwa Albalawi ◽  
Naushad Ahmad ◽  
...  
Keyword(s):  
Bond Formation ◽  
Xrd Analysis ◽  
One Pot ◽  
Hydrothermal Technique ◽  
Phase Purity ◽  
Antibacterial And Antifungal Activities ◽  
Fused Heterocycles ◽  
Nano Catalyst ◽  
Antibacterial And Antifungal ◽  
Synthesized Materials

In this article, a zirconia-based nano-catalyst (Nano-ZrO2), with intermolecular C-N bond formation for the synthesis of various benzimidazole-fused heterocycles in a concise method is reported. The robustness of this reaction is demonstrated by the synthesis of a series of benzimidazole drugs in a one-pot method. All synthesized materials were characterized using 1HNMR, 13CNMR, and LC-MS spectroscopy as well as microanalysis data. Furthermore, the synthesis of nano-ZrO2 was processed using a standard hydrothermal technique in pure form. The crystal structure of nano-ZrO2 and phase purity were studied, and the crystallite size was calculated from XRD analysis using the Debye–Scherrer equation. Furthermore, the antimicrobial activity of the synthesized benzimidazole drugs was evaluated in terms of Gram-positive, Gram-negative, and antifungal activity, and the results were satisfactory.

scholarly journals Silver-calcium-borates as better replacement for conventional organic antimicrobials in cosmetic products

2022 ◽  
Vol 11 (1) ◽  
pp. 113-120 ◽  
Author(s):  
A.L. Arunachalam ◽  
S. Induja ◽  
V. Parthasarathy ◽  
P.S. Raghavan
Keyword(s):  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Xrd Analysis ◽  
New Drugs ◽  
The Novel ◽  
Cosmetic Products ◽  
Bacterial Reduction ◽  
Phase Purity ◽  
Powder Xrd Analysis ◽  
Antibacterial And Antifungal

Microbes generally develop resistance towards organic antibacterial agents like ampicillin, Sulfonamides, methicillin, etc., and progressively new drugs are being invented to replace them. Hence, replacement of organic antibacterial agents with inorganic analogues requires constant research and the present investigation reports alternatives for conventional antimicrobial agents like methylparaben, diazolidinyl urea, etc., in the cosmetic products with silver incorporated calcium borates. The chemically synthesized silver-calcium borates have been analyzed for phase purity using powder XRD analysis, nature of bonding using FTIR vibrations, and morphology using SEM. The antibacterial and antifungal studies were carried out for the novel inorganic silver-calcium borates incorporated cosmetic products. The products were also subjected to thermal & photostability studies and found to be comparable with that of commercially available products. A minimum quantity of 3 ppm of silver-calcium borate concentration was required to bring about nearly 100% bacterial reduction in the cosmetic products.

scholarly journals Bicyclic [1,3,4]Thiadiazolo[3,2-α]Pyrimidine Analogues: Novel One-Pot Three-Component Synthesis, Antimicrobial, and Antioxidant Evaluation

2021 ◽  
Vol 11 (5) ◽  
pp. 12925-12936
Keyword(s):  
Spectral Data ◽  
Elemental Analysis ◽  
Sulfonic Acid ◽  
Aromatic Aldehydes ◽  
One Pot ◽  
Antibacterial And Antifungal Activities ◽  
Toluene Sulfonic Acid ◽  
Antioxidant Evaluation ◽  
Pyrimidine Analogues ◽  
Antibacterial And Antifungal

A novel one-pot three-component synthesis of 1-(7-methyl-2,5-diphenyl-5H-[1,3,4]thiadiazolo(3,2-α)pyrimidine-6-yl)ethanone (4a-i) derivatives via cyclo-condensation of substituted 2-amino-[1,3,4]thiadiazole (1a-c), acetylacetone (2) and various aromatic aldehydes (3a-c) in the presence of p-toluene sulfonic acid (PTSA) in acetonitrile. Spectral data and elemental analysis have characterized the newly synthesized compounds. The new analogs were screened for their antibacterial and antifungal activities. The majority of the tested compounds displayed significant to moderate efficacy against most of the designated organisms. Among the tested compounds, 4b, 4e, and 4h showed noteworthy efficacy against selected microbes, and compounds 4c and 4i were found to be exceptionally efficient against selected fungal strains. Compound 4c, 4e, 4f, 4i were also designated as best antioxidants against NOx.

scholarly journals An efficient, microwave-assisted, one-pot synthesis of novel 5,6,7,8-tetrahydroquinoline-3-carbonitriles

2011 ◽  
Vol 76 (6) ◽  
pp. 823-830 ◽  
Author(s):  
Dipti Dodiya ◽  
Haresh Ram ◽  
Amit Trivedi ◽  
Viresh Shah
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Microwave Assisted Synthesis ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
Antifungal Activities ◽  
Microwave Assisted ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

An efficient, microwave-assisted synthesis of novel 2-alkoxy- 5,6,7,8-tetrahydroquinoline-3-carbonitriles, which have not hitherto been reported, via reactions of cyclohexanone and arylidene malononitriles in the corresponding alcohols in presence of sodium is described. All the newly synthesized compounds were characterized by the IR, 1H-NMR, 13C-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

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