scholarly journals Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2005
Author(s):  
Adolfo Virgen-Ortiz ◽  
Alejandro Apolinar-Iribe ◽  
Irene Díaz-Reval ◽  
Hortensia Parra-Delgado ◽  
Saraí Limón-Miranda ◽  
...  

Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured in long-term treatments and with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs acute effects on glycemia during the next six h after an oral or intraperitoneal administration of the treatment in healthy and diabetic rats. In this study, the streptozotocin-nicotinamide intraperitoneal administration in male Wistar rats were used as a diabetes model. 10 mg/kg ZnONPs did not modify the baseline glucose in any group. Nevertheless, the ZnONPs short-term administration (100 mg/kg) induced a hyperglycemic response in a dose and route-dependent administration in healthy (130 ± 2 and 165 ± 10 mg/dL with oral and intraperitoneal, respectively) and diabetic rats (155 ± 2 and 240 ± 20 mg/dL with oral, and intraperitoneal, respectively). The diabetic rats were 1.5 fold more sensitive to ZnONPs effect by the intraperitoneal route. In conclusion, this study provides new information about the acute response of ZnONPs on fasting glycemia in diabetic and healthy rat models; these data are essential for possible future clinical approaches.

2019 ◽  
Author(s):  
Jesús José Ibarra-Leal ◽  
Luis Yocupicio ◽  
Alejandro Apolinar-Iribe ◽  
Irene Díaz-Reval ◽  
Hortensia Parra-Delgado ◽  
...  

In recent years, different studies carried out in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) can be good antidiabetic agents, this evidence was obtained from long-term treatments using repeated doses of zinc oxide nanoparticles. The goal of this work was to evaluate the acute effects during six hours post-administration of ZnONPs on glycemia in healthy and diabetic rats and to compare the effects of oral and intraperitoneal administration. For this study male Wistar rats were used and experimental diabetes was induced by streptozotocin-nicotinamide intraperitoneal administration. At short-term ZnONPs administration induced hyperglycemic response in healthy and diabetic rats, the effect was dose-dependent and administration route. The diabetic rats were more sensitive to ZnONPs effect. In conclusion, this study provides novel information about the acute effects of zinc oxide nanoparticles on the fasting glycemia in experimental diabetes in vivo model and healthy rats, these data are important for its future clinical applications.


Life Sciences ◽  
2021 ◽  
pp. 119823
Author(s):  
Maryam Farokhcheh ◽  
Leilabeigom Hejazian ◽  
Zeinab Akbarnejad ◽  
Fereshteh Pourabdolhossein ◽  
Seyed Mohammad Hosseini ◽  
...  

2015 ◽  
Vol 84 ◽  
pp. 154-160 ◽  
Author(s):  
Roghayeh Abbasalipourkabir ◽  
Hemen Moradi ◽  
Sadegh Zarei ◽  
Soheila Asadi ◽  
Aref Salehzadeh ◽  
...  

2020 ◽  
Vol 14 (8) ◽  
pp. 680-687
Author(s):  
Norhan Elassy ◽  
Shady El-Dafrawy ◽  
Amira O. Abd El-Azim ◽  
Om Ali Y. El-Khawaga ◽  
Amr Negm

2019 ◽  
Vol 56 (22-Suppl) ◽  
Author(s):  
Mohammed Kamal ◽  
Mohamed Khairy ◽  
Nada ELSadek ◽  
Mohamed Hussein

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mohamed Afifi ◽  
Omar A. Almaghrabi ◽  
Naif Mohammed Kadasa

The present study investigated the impact of zinc oxide nanoparticles (ZnONPs) on the oxidative status and sperm characteristics in diabetic rat testicular tissue. Forty male albino rats were used in this study; 10 of them served as a control and 30 rats were injected with a single dose (100 mg/kg) of streptozotocin intraperitoneally. They were subdivided into diabetic, diabetic + ZnONPs (10 mg/kg B.W.), and diabetic and cotreated with ZnONPs + insulin groups. The sperm count and motility were assessed. The activity and mRNA expression of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GRD), and Glutathion-S-Transferase (GST) were determined in the testicular tissue. Malondialdehyde (MDA) and reduced glutathione (GSH) levels were estimated in the testicular tissue. Sperm count and motility increased in ZnONPs treated diabetic rats. A significant increase in the activity and mRNA expression of SOD, CAT, GPx, GRD, and GST was shown in ZnONPs treated diabetic rats. MDA significantly decreased, while GSH increased in testicular tissue of ZnONPs treated diabetic rats. It was concluded that ZnONPs either alone or in combination with insulin have the ability to increase the sperm count and motility and protect the testicular tissue against the oxidative stress induced by diabetes in rats.


2019 ◽  
Vol 0 (0) ◽  
pp. 0-0 ◽  
Author(s):  
Mie Afify ◽  
Nervana Samy ◽  
Naglaa Hafez ◽  
Ahmed Alazzouni ◽  
El sayed Mahdy ◽  
...  

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