scholarly journals Embedding Ordered Mesoporous Carbons into Thermosensitive Hydrogels: A Cutting-Edge Strategy to Vehiculate a Cargo and Control Its Release Profile

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2165
Author(s):  
Monica Boffito ◽  
Rossella Laurano ◽  
Dimitra Giasafaki ◽  
Theodore Steriotis ◽  
Athanasios Papadopoulos ◽  
...  

The high drug loading capacity, cytocompatibility and easy functionalization of ordered mesoporous carbons (OMCs) make them attractive nanocarriers to treat several pathologies. OMCs’ efficiency could be further increased by embedding them into a hydrogel phase for an in loco prolonged drug release. In this work, OMCs were embedded into injectable thermosensitive hydrogels. In detail, rod-like (diameter ca. 250 nm, length ca. 700 nm) and spherical (diameter approximately 120 nm) OMCs were synthesized by nanocasting selected templates and loaded with ibuprofen through a melt infiltration method to achieve complete filling of their pores (100% loading yield). In parallel, an amphiphilic Poloxamer® 407-based poly(ether urethane) was synthesized (Mn¯ 72 kDa) and solubilized at 15 and 20% w/v concentration in saline solution to design thermosensitive hydrogels. OMC incorporation into the hydrogels (10 mg/mL concentration) did not negatively affect their gelation potential. Hybrid systems successfully released ibuprofen at a slower rate compared to control gels (gels embedding ibuprofen as such), but with no significant differences between rod-like and spherical OMC-loaded gels. OMCs can thus work as effective drug reservoirs that progressively release their payload over time and also upon encapsulation in a hydrogel phase, thus opening the way to their application to treat many different pathological states (e.g., as topical medications).

RSC Advances ◽  
2017 ◽  
Vol 7 (21) ◽  
pp. 12524-12533 ◽  
Author(s):  
Lei Liu ◽  
Shi-Da Xu ◽  
Feng-Yun Wang ◽  
Yue-Jun Song ◽  
Jie Liu ◽  
...  

Nitrogen doped ordered mesoporous carbons with a 3-D body-centered cubic pore structure have been synthesized by means of a low-temperature autoclaving route under basic conditions, showing excellent performances for supercapacitors and CO2 capture.


RSC Advances ◽  
2015 ◽  
Vol 5 (53) ◽  
pp. 42922-42930 ◽  
Author(s):  
Diganta Saikia ◽  
Tzu-Hua Wang ◽  
Chieh-Ju Chou ◽  
Jason Fang ◽  
Li-Duan Tsai ◽  
...  

Ordered mesoporous carbons CMK-3 and CMK-8 with different mesostructures are evaluated as anode materials for lithium-ion batteries. CMK-8 possesses higher reversible capacity, better cycling stability and rate capability than CMK-3.


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