Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

The review discusses the theoretical, experimental and toxicological aspects of the prospective biomedical application of functionalized magnetic nanoparticles (MNPs) activated by a low frequency non-heating alternating magnetic field (AMF). In this approach, known as nano-magnetomechanical activation (NMMA), the MNPs are used as mediators that localize and apply force to such target biomolecular structures as enzyme molecules, transport vesicles, cell organelles, etc., without significant heating. It is shown that NMMA can become a biophysical platform for a family of therapy methods including the addressed delivery and controlled release of therapeutic agents from transport nanomodules, as well as selective molecular nanoscale localized drugless nanomechanical impacts. It is characterized by low system biochemical and electromagnetic toxicity. A technique of 3D scanning of the NMMA region with the size of several mm to several cm over object internals has been described.

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Combining a low frequency rotating magnetic field with highly responsive EGF-functionalized magnetic nanoparticles to treat malignant glioma by mechanical destruction

Nanomedicine Nanotechnology Biology and Medicine ◽

10.1016/j.nano.2017.11.082 ◽

2018 ◽

Vol 14 (5) ◽

pp. 1766

Author(s):

Yajing Shen ◽

Congyu Wu ◽

Taro Q.P. Uyeda ◽

Gustavo R. Plaza ◽

Bin Liu ◽

...

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Malignant Glioma ◽

Low Frequency ◽

Rotating Magnetic Field ◽

Mechanical Destruction ◽

Functionalized Magnetic Nanoparticles

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Transmittance measurements in non-alternating magnetic field as reliable method for determining of heating properties of Fe3O4 magnetic nanoparticles

10.21203/rs.3.rs-458080/v1 ◽

2021 ◽

Author(s):

Magdalena Radović ◽

Marija Mirković ◽

Aleksandar S. Nikolić ◽

Milorad Kuraica ◽

Predrag Iskrenović ◽

...

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Radiochemical Purity ◽

Biomedical Application ◽

Alternating Magnetic Field ◽

Hyperthermia Treatment ◽

High Heating ◽

Theranostic Agents

Abstract Different phosphates and phosphonates have shown excellent coating ability toward magnetic nanoparticles, improving their stability and biocompatibility which enables their biomedical application. The magnetic hyperthermia efficiency of phosphates (IDP and IHP) and phosphonates (MDP and HEDP) coated Fe3O4 magnetic nanoparticles (MNPs) were evaluated in an alternating magnetic field. For a deeper understanding of hyperthermia, the behavior of investigated MNPs in the non-alternating magnetic field was monitored by measuring the transparency of the sample. To investigate their theranostic potential coated Fe3O4-MNPs were radiolabeled with radionuclide 177Lu. Phosphate coated MNPs were radiolabeled in high radiolabeling yield (> 99%) while phosphonate coated MNPs reached maximum radiolabeling yield of 78%. Regardless lower radiolabeling yield both radiolabeled phosphonate MNPs may be further purified reaching radiochemical purity of more than 95%. In vitro stabile radiolabeled nanoparticles in saline and HSA were obtained. The high heating ability of phosphates and phosphonates coated MNPs as sine qua non for efficient in vivo hyperthermia treatment and satisfactory radiolabeling yield justifies their further research in order to develop new theranostic agents.

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INCLUSION OF MAGNETIC NANOPARTICLES ОF MAGNETITE INTO PROTEIN PARTICLES OF CATALASE

BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES ◽

10.37747/2312-640x-2020-18-83-84 ◽

2020 ◽

pp. 83-84

Author(s):

N. Balabushevich ◽

K. Vlasova ◽

D. Volodkin ◽

Yu. Golovin ◽

N. Klyachko

Keyword(s):

Magnetic Field ◽

Enzyme Activity ◽

Magnetic Nanoparticles ◽

Low Frequency ◽

Alternating Magnetic Field ◽

Precipitation Method ◽

Immobilized Catalase ◽

Protein Particles ◽

Co Precipitation

In this work, vaterite microparticles with an immobilized catalase (enzyme) and magnetic nanoparticles (MNPs) of magnetite, obtained by the co-precipitation method, were used to study the enzyme activity under low frequency alternating magnetic field.

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In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field

Theranostics ◽

10.7150/thno.17089 ◽

2017 ◽

Vol 7 (13) ◽

pp. 3326-3337 ◽

Cited By ~ 20

Author(s):

Irina V. Belyanina ◽

Tatiana N. Zamay ◽

Galina S. Zamay ◽

Sergey S. Zamay ◽

Olga S. Kolovskaya ◽

...

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Cancer Cells ◽

Low Frequency ◽

Alternating Magnetic Field

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Polyamine-induced tannic acid co-deposition on magnetic nanoparticles for enzyme immobilization and efficient biodiesel production catalysed by an immobilized enzyme under an alternating magnetic field

Catalysis Science & Technology ◽

10.1039/c9cy01350d ◽

2019 ◽

Vol 9 (21) ◽

pp. 6015-6026 ◽

Cited By ~ 2

Author(s):

Wen Tang ◽

Tonghao Ma ◽

Lina Zhou ◽

Gaoya Wang ◽

Xiaoli Wang ◽

...

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Enzyme Immobilization ◽

Tannic Acid ◽

Immobilized Enzyme ◽

Alternating Magnetic Field ◽

Biodiesel Production ◽

Functionalized Magnetic Nanoparticles

In this study, we report facile, rapid and stable polyamine TEPA-induced tannic acid (TA) co-deposition system-functionalized magnetic nanoparticles, which may provide an improved nanoplatform for enzyme immobilization.

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