scholarly journals Association of Anabolic Effect of Calcitriol with Osteoclast-Derived Wnt 10b Secretion

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1164 ◽  
Author(s):  
Chien-Lin Lu ◽  
Jia-Fwu Shyu ◽  
Chia-Chao Wu ◽  
Chi-Feng Hung ◽  
Min-Tser Liao ◽  
...  
Keyword(s):  
Bone Development ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Tartrate Resistant Acid Phosphatase ◽  
Dependent Manner ◽  
Mesenchymal Progenitor Cells ◽  
Micro Computed Tomography ◽  
Cross Sectional ◽  
Maintenance Hemodialysis Patients

Canonical Wnt (Wingless/Integrated) signaling is crucial in bone development and the Wnt ligand can promote osteoblast differentiation from mesenchymal progenitor cells. Calcitriol, an active vitamin D3, is used clinically for treatment of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) patients. The bone effects of calcitriol in SHPT remains uncertain. We hypothesized that calcitriol improves bone mass by suppressing osteoclast activity, and simultaneously promoting Wnt ligand secretion. We designed a cross-sectional study in maintenance hemodialysis patients to explore the effects of calcitriol on different bone turnover markers and specifically emphasized the Wnt 10b levels. Then, we explored the source of Wnt 10b secretion by using osteoclasts and osteoblasts treated with calcitriol in cell culture studies. Finally, we explored the effects of calcitriol on bone microarchitectures in CKD mice, using the 5/6 nephrectomy CKD animal model with analysis using micro-computed tomography. Calcitriol promoted the growth of both trabecular and cortical bones in the CKD mice. Wnt 10b and Procollagen 1 N-terminal Propeptide (P1NP) significantly increased, but Tartrate-resistant acid phosphatase 5b (Trap 5b) significantly decreased in the calcitriol-treated maintenance hemodialysis patients. Calcitriol enhanced Wnt 10b secretion from osteoclasts in a dose-dependent manner. Treatment of SHPT with calcitriol improved the bone anabolism by inhibiting osteoclasts and promoting osteoblasts that might be achieved by increasing the Wnt 10b level.

Blood Pressure of Maintenance Hemodialysis Patients in the Dalmatian Region of Croatia: Differences between Hospital and Out-of-Hospital Dialysis Centers

2017 ◽  
Vol 44 (2) ◽  
pp. 110-121
Author(s):  
Marijana Gulin ◽  
Dragan Klarić ◽  
Mario Ilić ◽  
Josipa Radić ◽  
Vedran Kovačić ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Gain ◽  
Beta Blockers ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Interdialytic Weight Gain ◽  
Maintenance Hemodialysis Patients

Aims: This study was aimed at comparing the incidence of arterial hypertension and blood pressure (BP) variance in hospital and out-of-hospital hemodialysis (HD) patients during HD sessions. Methods: A cross-sectional study was conducted for 1 week at all the HD centers in Dalmatia, Croatia. The pre-, intra-, and post-dialysis BP values were collected for 3 consecutive HD sessions per patient. Results: Of the 399 subjects, 73.9% were hypertensives, who showed higher interdialytic weight gain compared to the normotensives (2.58 vs. 2.40). Hospital and out-of-hospital HD patients received identical antihypertensive therapies, except that beta blockers were more frequently administered to out-of-hospital HD patients. Higher pre-, intra-, and post-dialysis BP values were recorded in patients at out-of-hospital HD centers. Conclusion: The differences in BP variability and antihypertensive therapies administered to hospital HD patients as compared to out-of-hospital HD patients may reflect differing approaches by the nephrologists at these centers.

Underreporting of Energy Intake in Maintenance Hemodialysis Patients: A Cross-sectional Study

2012 ◽  
Vol 22 (6) ◽  
pp. 578-583 ◽  
Author(s):  
Denise Mafra ◽  
Cristiane Moraes ◽  
Viviane O. Leal ◽  
Najla E. Farage ◽  
Milena B. Stockler-Pinto ◽  
...  
Keyword(s):  
Energy Intake ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Maintenance Hemodialysis Patients

Arteriosclerosis in Dialysis Patients

1996 ◽  
Vol 19 (11) ◽  
pp. 638-644 ◽  
Author(s):  
J. Bommer ◽  
E. Strohbeck ◽  
J. Goerich ◽  
M. Bahner ◽  
I. Zuna
Keyword(s):  
Calcium Phosphate ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Maintenance Hemodialysis ◽  
Time Interval ◽  
Dialysis Patients ◽  
Cross Sectional ◽  
Vldl Cholesterol

Arteriosclerosis is a constant problem in long-term hemodialysis patients. Computer tomography of the abdominal aorta allows a well-defined and reproducible evaluation of aortosclerosis. In the cross-sectional study, aortosclerosis was significantly accelerated in 84 chronic hemodialysis patients and was comparable to the results found in 20-year older control patients without renal disease. The increase of aortosclerosis correlated significantly with age of the patient, smoking, and duration of dialysis therapy. Furthermore, increased VLDL cholesterol and decreased HDL cholesterol seem to enhance aortosclerosis in our dialysis patients. In the longitudinal study (two CT scans with a time interval of 87 ± 62.7 months) in 36 dialysis patients, progressed aortosclerosis correlated significantly with the long duration of hypertriglyceridemia, VLDL cholesterol, uric acid, and calcium phosphate products. Progression of aortosclerosis was reduced in parathyroidectomized patients. The study suggests that premature aortosclerosis is found in dialysis patients. In addition to the common risk factor of aortosclerosis, disturbed calcium phosphate and parathyroid hormone metabolism seem to enhance aortosclerosis in patients under maintenance hemodialysis.

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