scholarly journals Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 861 ◽  
Author(s):  
Claire S Byrne ◽  
Edward S Chambers ◽  
Tom Preston ◽  
Catriona Tedford ◽  
Jerusa Brignardello ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Energy Intake ◽  
Food System ◽  
Resting Energy Expenditure ◽  
Food Products ◽  
Fat Free Mass ◽  
Palatable Food ◽  
Ad Libitum ◽  
Bread Roll ◽  
Resting Energy

Supplementation with inulin-propionate ester (IPE), which delivers propionate to the colon, suppresses ad libitum energy intake and stimulates the release of satiety hormones acutely in humans, and prevents weight gain. In order to determine whether IPE remains effective when incorporated into food products (FP), IPE needs to be added to a widely accepted food system. A bread roll and fruit smoothie were produced. Twenty-one healthy overweight and obese humans participated. Participants attended an acclimatisation visit and a control visit where they consumed un-supplemented food products (FP). Participants then consumed supplemented-FP, containing 10 g/d inulin or IPE for six days followed by a post-supplementation visit in a randomised crossover design. On study visits, supplemented-FP were consumed for the seventh time and ad libitum energy intake was assessed 420 min later. Blood samples were collected to assess hormones and metabolites. Resting energy expenditure (REE) was measured using indirect calorimetry. Taste and appearance ratings were similar between FP. Ad libitum energy intake was significantly different between treatments, due to a decreased intake following IPE-FP. These observations were not related to changes in blood hormones and metabolites. There was an increase in REE following IPE-FP. However, this effect was lost after correcting for changes in fat free mass. Our results suggest that IPE suppresses appetite and may alter REE following its incorporation into palatable food products.

Increased resting energy expenditure, fat oxidation, and food intake in patients with highly active antiretroviral therapy-associated lipodystrophy

2007 ◽  
Vol 292 (3) ◽  
pp. E687-E692 ◽  
Author(s):  
Jussi Sutinen ◽  
Hannele Yki-Järvinen
Keyword(s):  
Antiretroviral Therapy ◽  
Food Intake ◽  
Energy Expenditure ◽  
Lipid Oxidation ◽  
Energy Intake ◽  
Highly Active Antiretroviral Therapy ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
Highly Active ◽  
Resting Energy

Highly active antiretroviral therapy (HAART) is associated with metabolic adverse events such as lipodystrophy in human immunodeficiency virus (HIV)-infected patients. The objective of the present study was to evaluate the effects of HAART-associated lipodystrophy on resting energy expenditure and caloric intake. In this cross-sectional study we compared resting energy expenditure (REE) and energy intake in 30 HAART-treated patients with lipodystrophy (HAART+LD+) with 13 HAART-treated patients without lipodystrophy (HAART+LD−). REE was measured using indirect calorimetry, and energy intake was recorded as a 3-day diary of food intake. REE (5,180 ± 160 vs. 4,260 ± 150 J/min, P < 0.01) and also REE expressed per fat-free mass (86 ± 1 vs. 78 ± 2 J·kg fat-free mass−1·min−1, P < 0.01) were significantly higher in the HAART+LD+ than the HAART+LD− group. Rate of lipid oxidation was significantly higher in the HAART+LD+ than the HAART+LD− group. Total energy and fat intakes were significantly increased in the HAART+LD+ compared with the HAART+LD− group. These results imply that HAART-associated lipodystrophy is associated with increased REE and lipid oxidation and with increased caloric and fat intake.

scholarly journals Reduced Albumin Concentration Predicts Weight Gain and Higher Ad Libitum Energy Intake in Humans

2021 ◽  
Vol 12 ◽  
Author(s):  
Alessio Basolo ◽  
Takafumi Ando ◽  
Douglas C. Chang ◽  
Tim Hollstein ◽  
Jonathan Krakoff ◽  
...  
Keyword(s):  
Weight Gain ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Fat Free Mass ◽  
Albumin Concentration ◽  
Plasma Albumin ◽  
Clinical Trial Registration ◽  
Ad Libitum ◽  
Intake Regulation

ObjectiveCirculating albumin is negatively associated with adiposity but whether it is associated with increased energy intake, lower energy expenditure or weight gain has not been examined.MethodsIn study 1 (n=238; 146 men), we evaluated whether fasting albumin concentration was associated with 24-h energy expenditure and ad libitum energy intake. In study 2 (n=325;167 men), we evaluated the association between plasma albumin and change in weight and body composition.ResultsAfter adjustment for known determinants of energy intake lower plasma albumin concentration was associated with greater total daily energy intake (β= 89.8 kcal/day per 0.1 g/dl difference in plasma albumin, p=0.0047). No associations were observed between plasma albumin concentrations and 24-h energy expenditure or 24-h respiratory quotient (p&gt;0.2). Over 6 years, volunteers gained on average 7.5 ± 11.7 kg (p&lt;0.0001). Lower albumin concentrations were associated with greater weight [β=3.53 kg, p=0.039 (adjusted for age, sex, follow up time), CI 0.16 to 6.21 per 1 g/dl difference albumin concentration] and fat mass (β=2.3 kg, p=0.022), respectively, but not with changes in fat free mass (p=0.06).ConclusionsLower albumin concentrations were associated with increased ad libitum food intake and weight gain, indicating albumin as a marker of energy intake regulation.Clinical Trial RegistrationClinicalTrials.gov, identifiers NCT00340132, NCT00342732.

Resting Energy Expenditure in Obese Women with Primary Hypothyroidism and Appropriate Levothyroxine Replacement Therapy

2020 ◽  
Vol 105 (4) ◽  
pp. e1741-e1748 ◽  
Author(s):  
Emanuele Muraca ◽  
Stefano Ciardullo ◽  
Alice Oltolini ◽  
Francesca Zerbini ◽  
Eleonora Bianconi ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Replacement Therapy ◽  
Resting Energy Expenditure ◽  
Primary Hypothyroidism ◽  
Normal Serum ◽  
Fat Free Mass ◽  
Model Assessment ◽  
Obese Women ◽  
Resting Energy

Abstract Context Growing evidence suggests that appropriate levothyroxine (LT4) replacement therapy may not correct the full set of metabolic defects afflicting individuals with hypothyroidism. Objective To assess whether obese subjects with primary hypothyroidism are characterized by alterations of the resting energy expenditure (REE). Design Retrospective analysis of a set of data about obese women attending the outpatients service of a single obesity center from January 2013 to July 2019. Patients A total of 649 nondiabetic women with body mass index (BMI) &gt; 30 kg/m2 and thyrotropin (TSH) level 0.4–4.0 mU/L were segregated into 2 groups: patients with primary hypothyroidism taking LT4 therapy (n = 85) and patients with normal thyroid function (n = 564). Main outcomes REE and body composition assessed using indirect calorimetry and bioimpedance. Results REE was reduced in women with hypothyroidism in LT4 therapy when compared with controls (28.59 ± 3.26 vs 29.91 ± 3.59 kcal/kg fat-free mass (FFM)/day), including when adjusted for age, BMI, body composition, and level of physical activity (P = 0.008). This metabolic difference was attenuated only when adjustment for homeostatic model assessment of insulin resistance (HOMA-IR) was performed. Conclusions This study demonstrated that obese hypothyroid women in LT4 therapy, with normal serum TSH level compared with euthyroid controls, are characterized by reduced REE, in line with the hypothesis that standard LT4 replacement therapy may not fully correct metabolic alterations related to hypothyroidism. We are not able to exclude that this feature may be influenced by the modulation of insulin sensitivity at the liver site, induced by LT4 oral administration.

Anthropometric measured fat-free mass as essential determinant of resting energy expenditure for pregnant and non-pregnant women

Nutrition ◽  
2011 ◽  
Vol 27 (9) ◽  
pp. 885-890 ◽  
Author(s):  
Miloslav Hronek ◽  
Petr Klemera ◽  
Jindrich Tosner ◽  
Dana Hrnciarikova ◽  
Zdenek Zadak
Keyword(s):  
Energy Expenditure ◽  
Pregnant Women ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
Resting Energy

Resting energy expenditure in girls with Turner syndrome

2017 ◽  
Vol 30 (3) ◽  
Author(s):  
Gerhard Binder ◽  
Laura Frank ◽  
Julian Ziegler ◽  
Gunnar Blumenstock ◽  
Roland Schweizer
Keyword(s):  
Energy Expenditure ◽  
Short Stature ◽  
Turner Syndrome ◽  
Resting Energy Expenditure ◽  
Bioelectrical Impedance ◽  
Fat Free Mass ◽  
Gh Treatment ◽  
Age Related ◽  
Resting Energy

AbstractBackground:Knowledge concerning energy metabolism in Turner syndrome (TS) is lacking. We compared the resting energy expenditure per fat-free mass (REE/FFM) in TS with other girls with short stature treated with growth hormone (GH) and age-related controls.Methods:We measured prospectively REE by spirometry under fasting conditions in the morning in 85 short prepubertal girls at the start of GH treatment. Diagnoses were TS (n=20), GH deficiency (GHD) (n=38) and small for gestational age (SGA) short stature (n=27). Additionally, 20 age-related controls were studied. Mean ages were 8.3 (TS), 7.1 (GHD), 6.9 (SGA) and 8.5 years (controls). Mean heights were −2.90 (TS), −3.32 (GHD), −3.69 (SGA) and −0.03 standard deviation scores (SDS) (controls). FFM was measured by bioelectrical impedance analysis (BIA).Results:At the start of GH girls with TS showed insignificantly higher REE per FFM (REE/FFM) (mean±SD; 65±9 kcal/kg×day) than did the other female patients (62±9 kcal/kg×day) (p>0.23). The healthy controls had significantly lower REE/FFM (35±4 kcal/kg×day) (p<0.001). Follow-up examination of the patients after 6 or 12 months revealed decreasing REE/FFM in TS (62±9 kcal/kg×day) resulting in comparable REE/FFM in all three patient groups.Conclusions:At baseline short girls with TS had insignificantly higher REE/FFM than short children with SGA or GHD, but in follow-up this difference was not detectable any more. Future studies are necessary to understand this observation.

Prediction of resting energy expenditure from fat-free mass and fat mass

1992 ◽  
Vol 56 (5) ◽  
pp. 848-856 ◽  
Author(s):  
K M Nelson ◽  
R L Weinsier ◽  
C L Long ◽  
Y Schutz
Keyword(s):  
Energy Expenditure ◽  
Fat Mass ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
Resting Energy

scholarly journals Body composition and resting energy expenditure in humans: role of fat, fat-free mass and extracellular fluid

2000 ◽  
Vol 24 (9) ◽  
pp. 1153-1157 ◽  
Author(s):  
S Nielsen ◽  
DD Hensrud ◽  
S Romanski ◽  
JA Levine ◽  
B Burguera ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Extracellular Fluid ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
Resting Energy

The contribution of fat-free mass to resting energy expenditure: implications for weight loss strategies in the treatment of adolescent obesity

2015 ◽  
Vol 27 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Matthew G. Browning ◽  
Ronald K. Evans
Keyword(s):  
Weight Loss ◽  
Energy Balance ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Strong Relationship ◽  
Adolescent Obesity ◽  
Normal Weight ◽  
Fat Free Mass ◽  
Weight Loss Outcomes ◽  
Resting Energy

AbstractOwing to the strong relationship between fat-free mass (FFM) and resting energy expenditure (REE), the preservation of FFM is often emphasized in the treatment of adolescent obesity. Typical treatment regimens including an increased dietary consumption of protein and participation in resistance training are common components of adolescent weight management programs, despite limited evidence of a positive influence of FFM on weight loss outcomes in adolescents. Given the larger volume of FFM in obese relative to normal weight adolescents and the common treatment goals of both maximizing weight loss and attenuating the loss of FFM, a better understanding of the influence of FFM on energy balance is needed to determine whether strategies to preserve lean tissue or maximize absolute weight loss should be most emphasized. We review the associations among FFM, REE, and weight loss outcomes, focusing on how these relationships might influence energy balance in obese adolescents.

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