scholarly journals Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis. A Nutritional Perspective

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 548 ◽  
Author(s):  
Andrea Ticinesi ◽  
Antonio Nouvenne ◽  
Giulia Chiussi ◽  
Giampiero Castaldo ◽  
Angela Guerra ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stones ◽  
Vegetable Intake ◽  
Stone Disease ◽  
Oxalobacter Formigenes ◽  
Oxalate Secretion ◽  
Gut Mucosa ◽  
Urinary Microbiota ◽  
Dietary Oxalate

Recent studies have shown that patients with kidney stone disease, and particularly calcium oxalate nephrolithiasis, exhibit dysbiosis in their fecal and urinary microbiota compared with controls. The alterations of microbiota go far beyond the simple presence and representation of Oxalobacter formigenes, a well-known symbiont exhibiting a marked capacity of degrading dietary oxalate and stimulating oxalate secretion by the gut mucosa. Thus, alterations of the intestinal microbiota may be involved in the pathophysiology of calcium kidney stones. However, the role of nutrition in this gut-kidney axis is still unknown, even if nutritional imbalances, such as poor hydration, high salt, and animal protein intake and reduced fruit and vegetable intake, are well-known risk factors for kidney stones. In this narrative review, we provide an overview of the gut-kidney axis in nephrolithiasis from a nutritional perspective, summarizing the evidence supporting the role of nutrition in the modulation of microbiota composition, and their relevance for the modulation of lithogenic risk.

Role of Oxalobacter formigenes in Calcium Oxalate Stone Disease: A Study from North India

2002 ◽  
Vol 41 (3) ◽  
pp. 318-322 ◽  
Author(s):  
R Kumar ◽  
M Mukherjee ◽  
M Bhandari ◽  
A Kumar ◽  
H Sidhu ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Stone Disease ◽  
North India ◽  
Oxalobacter Formigenes ◽  
Calcium Oxalate Stone

scholarly journals The role of Oxalobacter formigenes colonization in calcium oxalate stone disease

2013 ◽  
Vol 83 (6) ◽  
pp. 1144-1149 ◽  
Author(s):  
Roswitha Siener ◽  
Ursula Bangen ◽  
Harmeet Sidhu ◽  
Ruth Hönow ◽  
Gerd von Unruh ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Stone Disease ◽  
Oxalobacter Formigenes ◽  
Calcium Oxalate Stone

Insights about urinary hippuric and citric acid as biomarkers of fruit and vegetable intake in patients with kidney stones: The role of age and sex

Nutrition ◽  
2019 ◽  
Vol 59 ◽  
pp. 83-89 ◽  
Author(s):  
Angela Guerra ◽  
Andrea Ticinesi ◽  
Franca Allegri ◽  
Antonio Nouvenne ◽  
Beatrice Prati ◽  
...  
Keyword(s):  
Citric Acid ◽  
Kidney Stones ◽  
Vegetable Intake ◽  
Fruit And Vegetable Intake ◽  
Fruit And Vegetable ◽  
Age And Sex

scholarly journals Oxalobacter formigenes Colonization and Oxalate Dynamics in a Mouse Model

2015 ◽  
Vol 81 (15) ◽  
pp. 5048-5054 ◽  
Author(s):  
Xingsheng Li ◽  
Melissa L. Ellis ◽  
John Knight
Keyword(s):  
Kidney Stones ◽  
Host Bacterium ◽  
Urinary Oxalate ◽  
Oxalobacter Formigenes ◽  
Content Type ◽  
Oxalate Excretion ◽  
Urinary Oxalate Excretion ◽  
Dietary Oxalate ◽  
Different Levels ◽  
Unique Ability

ABSTRACTAnimal and human studies have provided compelling evidence that colonization of the intestine withOxalobacter formigenesreduces urinary oxalate excretion and lowers the risk of forming calcium oxalate kidney stones. The mechanism providing protection appears to be related to the unique ability ofO. formigenesto rely on oxalate as a major source of carbon and energy for growth. However, much is not known about the factors that influence colonization and host-bacterium interactions. We have colonized mice withO. formigenesOxCC13 and systematically investigated the impacts of diets with different levels of calcium and oxalate onO. formigenesintestinal densities and urinary and intestinal oxalate levels. Measurement of intestinal oxalate levels in mice colonized or not colonized withO. formigenesdemonstrated the highly efficient degradation of soluble oxalate byO. formigenesrelative to other microbiota. The ratio of calcium to oxalate in diets was important in determining colonization densities and conditions where urinary oxalate and fecal oxalate excretion were modified, and the results were consistent with those from studies we have performed with colonized and noncolonized humans. The use of low-oxalate purified diets showed that 80% of animals retainedO. formigenescolonization after a 1-week dietary oxalate deprivation. Animals not colonized withO. formigenesexcreted two times more oxalate in feces than they had ingested. This nondietary source of oxalate may play an important role in the survival ofO. formigenesduring periods of dietary oxalate deprivation. These studies suggest that the mouse will be a useful model to further characterize interactions betweenO. formigenesand the host and factors that impact colonization.

scholarly journals Genome Sequence of Oxalobacter formigenes Strain HC-1

2017 ◽  
Vol 5 (27) ◽  
Author(s):  
Marguerite Hatch ◽  
Milton J. Allison ◽  
Fahong Yu ◽  
William Farmerie
Keyword(s):  
Calcium Oxalate ◽  
Genome Sequence ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Human Strain ◽  
Oxalobacter Formigenes ◽  
Human Gut ◽  
Content Type

ABSTRACT The lack of Oxalobacter formigenes colonization of the human gut has been correlated with the formation of calcium oxalate kidney stones and also with the number of recurrent kidney stone episodes. Here, we present the genome sequence of HC-1, a human strain isolated from an individual residing in Iowa, USA.

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