scholarly journals Yogurt Enriched with Inulin Ameliorated Reproductive Functions and Regulated Gut Microbiota in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Mice

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 279
Author(s):  
Tiange Li ◽  
Yue Zhang ◽  
Jiajia Song ◽  
Lijun Chen ◽  
Min Du ◽  
...  
Keyword(s):  
Bile Acid ◽  
Polycystic Ovary Syndrome ◽  
Gut Microbiota ◽  
Polycystic Ovary ◽  
Body Weight Gain ◽  
The Body ◽  
Mice Model ◽  
Ovary Syndrome ◽  
Kegg Pathways ◽  
Bile Acid Profiles

The effects of synbiotic yogurt supplemented with inulin on the pathological manifestations and gut microbiota–bile acid axis were investigated using a dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) mice model. Female C57BL/6J mice were injected subcutaneously with DHEA at a dose of 6 mg/100 g BW for 20 days to establish a PCOS mouse model. Then, the PCOS mice were treated with yogurt containing inulin (6% w/w) at 15 mL/kg BW for 24 days. Results showed that supplementation of synbiotic yogurt enriched with inulin to PCOS mice decreased the body weight gain, improved estrus cycles and ovary morphology, and reduced the levels of luteinizing hormone while increasing the levels of follicle-stimulating hormone and interleukin-22 in serum. At the genus level, synbiotic yogurt increased the relative abundance of Lactobacillus, Bifidobacterium, and Akkermansia. PICRUSt analysis indicated that KEGG pathways including bile acid biosynthesis were changed after inulin-enriched synbiotic yogurt supplementation. Synbiotic yogurt enriched with inulin also modulated the bile acid profiles. In conclusion, inulin-enriched synbiotic yogurt alleviated reproductive dysfunction and modulated gut microbiota and bile acid profiles in PCOS mice.

scholarly journals Troxerutin protects against DHT-induced polycystic ovary syndrome in rats

2020 ◽  
Author(s):  
Zixuan Gao ◽  
Xiaochen Ma ◽  
Yuhang Ge ◽  
Lei Wang ◽  
Ping Fu ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Protective Effect ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Body Weight Gain ◽  
Neuroprotective Effect ◽  
The Body ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Gonadotrophin Releasing Hormone

Abstract The exact pathogenesis of polycystic ovary syndrome (PCOS), the most common neuroendocrine disorder in women of reproductive age, has not been fully elucidated. Recent studies suggested that chronic inflammation and neurotransmitter disorder involved in the progress of PCOS. Troxerutin, a natural flavonoid, was reported to possess neuroprotective effect in several disease models by inhibiting inflammation or enhancing neurotrophic factor. In this study, we investigated the possible protective effect and mechanism of troxerutin in a dihydrotestosterone (DHT)-induced rat model of PCOS. The PCOS rat models were treated with troxerutin at a dose of 150mg/kg or 300mg/kg for up to 4 weeks. Results showed that 300mg/kg troxerutin significantly decreased the body weight gain and improved the pathological changes of ovary induced by DHT. Meanwhile, the elevated gonadotrophin-releasing hormone (GnRH), gonadotrophin and testosterone in the serum of PCOS rats were reduced with the treatment of troxerutin. The expression of kisspeptin and NKB in arcuate nucleus and their receptors kiss1r and NK3r in GnRH positive neurons of median eminence were markedly decreased in troxerutin-treated rats. Of note, the GnRH inhibitory regulator GABA and stimulatory regulator glutamate were also restored to the normal level by troxerutin. The present study indicated that troxerutin may exhibit a protective effect in PCOS rat model via regulating neurotransmitter release.

scholarly journals Troxerutin protects against DHT-induced polycystic ovary syndrome in rats

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Zixuan Gao ◽  
Xiaochen Ma ◽  
Jing Liu ◽  
Yuhang Ge ◽  
Lei Wang ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Protective Effect ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Body Weight Gain ◽  
Neuroprotective Effect ◽  
The Body ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Gonadotrophin Releasing Hormone

AbstractThe exact pathogenesis of polycystic ovary syndrome (PCOS), the most common neuroendocrine disorder in women of reproductive age, has not been fully elucidated. Recent studies suggested that chronic inflammation and neurotransmitter disorder involved in the progress of PCOS. Troxerutin, a natural flavonoid, was reported to possess neuroprotective effect in several disease models by inhibiting inflammation or enhancing neurotrophic factor. In this study, we investigated the possible protective effect and mechanism of troxerutin in a dihydrotestosterone (DHT)-induced rat model of PCOS. The PCOS rat models were treated with troxerutin at a dose of 150 mg/kg or 300 mg/kg for up to 4 weeks. Results showed that 300 mg/kg troxerutin significantly decreased the body weight gain and improved the pathological changes of ovary induced by DHT. Meanwhile, the elevated gonadotrophin-releasing hormone (GnRH), gonadotrophin and testosterone in the serum of PCOS rats were reduced with the treatment of troxerutin. The expression of kisspeptin and NKB in arcuate nucleus and their receptors kiss1r and NK3r in GnRH positive neurons of median eminence were markedly decreased in troxerutin-treated rats. Of note, the GnRH inhibitory regulator GABA and stimulatory regulator glutamate were also restored to the normal level by troxerutin. The present study indicated that troxerutin may exhibit a protective effect in PCOS rat model via regulating neurotransmitter release.

scholarly journals Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

2019 ◽  
Vol 25 (9) ◽  
pp. 1459-1459 ◽  
Author(s):  
Xinyu Qi ◽  
Chuyu Yun ◽  
Lulu Sun ◽  
Jialin Xia ◽  
Qing Wu ◽  
...  
Keyword(s):  
Bile Acid ◽  
Polycystic Ovary Syndrome ◽  
Gut Microbiota ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Interleukin 22

scholarly journals Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

2019 ◽  
Vol 25 (8) ◽  
pp. 1225-1233 ◽  
Author(s):  
Xinyu Qi ◽  
Chuyu Yun ◽  
Lulu Sun ◽  
Jialin Xia ◽  
Qing Wu ◽  
...  
Keyword(s):  
Bile Acid ◽  
Polycystic Ovary Syndrome ◽  
Gut Microbiota ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Interleukin 22

scholarly journals Evaluation on the characteristics of gut microbiome in polycystic ovary syndrome rats induced by dihydrotestosterone or letrozole

2021 ◽  
Author(s):  
Yan-hua Zheng ◽  
Ying Xu ◽  
Hong-xia Ma ◽  
Cheng-jie Liang ◽  
Tong Yang
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Polycystic Ovary ◽  
Nucleotide Metabolism ◽  
Control Group ◽  
Polycystic Ovaries ◽  
Ovary Syndrome ◽  
Kegg Pathways ◽  
Principal Coordinates

Abstract Background: Etiology of polycystic ovary syndrome (PCOS) is unclear. Recent reports indicated that gut microbiota regulates metabolism and plays a major role in the development of PCOS. The present study aimed to investigate and compare the effects of dihydrotestosterone or letrozole on the gut microbiome in rats.Methods: We used dihydrotestosterone (DHT) or letrozole (LET) to induce PCOS model rats. At the end of the experiment, ovarian morphology, hormonal and metabolic status were investigated in all rats. We analyzed the gut microbiome of rats by deep sequencing the 16S rDNA V3-V4 hypervariable regions. Predictive metagenomics profiling using PICRUST revealed functional alternation of the KEGG pathways in rats.Result: Rats induced by letrozole exhibited endocrine and reproductive characteristics, such as hyperandrogenism, abnormal oestrus cycles or complete acyclic, polycystic ovaries, and obesity. DHT-induced rats were obesity, irregular oestrus cycles, polycystic ovaries, with lower level of HDL-C and lower activity of SOD than controls. The bacterial diversity (Chao1 and Ace) of DHT group was decreased compared with the control group. Furthermore, principal coordinates analysis revealed that DHT and control groups could be distinguished from each other. The DHT group exhibited increased numbers of Firmicutes, Cyanobacteria, Actinobacteria and Saccharibacteria, and decreased Bacteroidetes compared with the control group at the phylum level. Moreover, PICRUST-predicted KEGG pathways related to Carbohydrate metabolism, Amino acid metabolism, Metabolism of terpenoids and polyketides, Metabolism of other amino acids, Replication and repair, Lipid metabolism and Energy metabolism, Translation, Folding, sorting and degradation and Xenobiotics biodegradation and metabolism were significantly elevated in the DHT group. And pathways related to Metabolism of terpenoids and polyketides, Replication and repair, Xenobiotics biodegradation and metabolism, Nucleotide metabolism, Infectious diseases and Excretory system were significantly elevated in the LET group.Conclusion: The findings of the present study indicated that DHT affected the composition and diversity of gut microbial community, and leads to the gut dysbiosis. KEGG function profiles calculated by PICRUST suggested that DHT may affect metabolism of the gut microbiota more directly than letrozle.

scholarly journals Troxerutin protects against DHT-induced polycystic ovary syndrome in rats

2020 ◽  
Author(s):  
Zixuan Gao ◽  
Xiaochen Ma ◽  
Jing Liu ◽  
Yuhang Ge ◽  
Lei Wang ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Protective Effect ◽  
Rat Model ◽  
Polycystic Ovary ◽  
Body Weight Gain ◽  
Neuroprotective Effect ◽  
The Body ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Gonadotrophin Releasing Hormone

Abstract The exact pathogenesis of polycystic ovary syndrome (PCOS), the most common neuroendocrine disorder in women of reproductive age, has not been fully elucidated. Recent studies suggested that chronic inflammation and neurotransmitter disorder involved in the progress of PCOS. Troxerutin, a natural flavonoid, was reported to possess neuroprotective effect in several disease models by inhibiting inflammation or enhancing neurotrophic factor. In this study, we investigated the possible protective effect and mechanism of troxerutin in a dihydrotestosterone (DHT)-induced rat model of PCOS. The PCOS rat models were treated with troxerutin at a dose of 150mg/kg or 300mg/kg for up to 4 weeks. Results showed that 300mg/kg troxerutin significantly decreased the body weight gain and improved the pathological changes of ovary induced by DHT. Meanwhile, the elevated gonadotrophin-releasing hormone (GnRH), gonadotrophin and testosterone in the serum of PCOS rats were reduced with the treatment of troxerutin. The expression of kisspeptin and NKB in arcuate nucleus and their receptors kiss1r and NK3r in GnRH positive neurons of median eminence were markedly decreased in troxerutin-treated rats. Of note, the GnRH inhibitory regulator GABA and stimulatory regulator glutamate were also restored to the normal level by troxerutin. The present study indicated that troxerutin may exhibit a protective effect in PCOS rat model via regulating neurotransmitter release.

scholarly journals Use of Inositols in Polycystic Ovary Syndrome

2020 ◽  
Vol 16 (28) ◽  
pp. 24-34
Author(s):  
O.A. Pustotina ◽  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Ovarian Function ◽  
Polycystic Ovary ◽  
The Body ◽  
Metabolic Parameters ◽  
Ovary Syndrome ◽  
Pathogenetic Role

The article presents key data on the physiology of inositols in the body, their pathogenetic role in the development of polycystic ovary syndrome, and the possibilities of myo-inositol and D-chiro-inositol in the restoration of ovarian function, metabolic parameters, and overcoming of infertility.

Polycystic ovary syndrome and gut microbiota

2021 ◽  
Vol 3_2021 ◽  
pp. 36-43
Author(s):  
Chernukha G.E. Chernukha ◽  
Miroshina E.D. Miroshina ◽  
Priputnevich T.V. Priputnevich ◽  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Gut Microbiota ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Inulin and metformin ameliorate polycystic ovary syndrome via anti-inflammation and modulating gut microbiota in mice

2019 ◽  
Vol 66 (10) ◽  
pp. 859-870 ◽  
Author(s):  
Jing Xue ◽  
Xiaorong Li ◽  
Ping Liu ◽  
Ke Li ◽  
Liping Sha ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Gut Microbiota ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Anti Inflammation

Circulating gut microbiota metabolite trimethylamine N‐oxide and oral contraceptive use in polycystic ovary syndrome

2019 ◽  
Vol 91 (6) ◽  
pp. 810-815 ◽  
Author(s):  
Nesrin Damla Eyupoglu ◽  
Ezgi Caliskan Guzelce ◽  
Aylin Acikgoz ◽  
Esra Uyanik ◽  
Bodil Bjørndal ◽  
...  
Keyword(s):  
Oral Contraceptive ◽  
Polycystic Ovary Syndrome ◽  
Gut Microbiota ◽  
Contraceptive Use ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Oral Contraceptive Use
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