scholarly journals A Systematic Review of Epstein–Barr Virus Latent Membrane Protein 1 (LMP1) Gene Variants in Nasopharyngeal Carcinoma

Pathogens ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1057
Author(s):  
Ana Banko ◽  
Danijela Miljanovic ◽  
Ivana Lazarevic ◽  
Andja Cirkovic
Keyword(s):  
Systematic Review ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Meta Analysis ◽  
Biological Significance ◽  
Potential Contribution ◽  
Gene Variants ◽  
Barr Virus ◽  
Lmp1 Gene ◽  
Epstein Barr

Nasopharyngeal carcinoma (NPC) is an aggressive tumor with a complex etiology. Although Epstein–Barr virus (EBV) infection is known environmental factor for NPC development, the degree to which EBV naturally infects nasopharyngeal epithelium and the moment when and why the virus actively begins to affect cell transformation remains questionable. The aim of this study was to explore the association between LMP1 gene variability and potential contribution to NPC development. A systematic review was performed through searches of PubMed, Web of Science (WoS) and SCOPUS electronic databases. Additionally, meta-analysis of the difference in the frequency of seven LMP1 gene variants in NPC and control individuals was accomplished. The results from this study give a proof of concept for the association between 30 bp deletion (OR = 3.53, 95% CI = 1.48–8.43) and Xhol loss (OR = 14.17, 95% CI = 4.99–40.20) and NPC susceptibility when comparing biopsies from NPC and healthy individuals. Otherwise, 30 bp deletion from NPC biopsies could not distinguish NPC from EBV-associated non-NPC tumors (OR = 1.74, 95% CI = 0.81–3.75). However, B95-8, China1 and North Carolina variants were uncommon for NPC individuals. Much more efforts remains to be done to verify the biological significance of the differences observed, define so-called “high-risk” EBV variants and make it available for clinical application.

scholarly journals The initial study of EBNA-2 polymorphisms in nasopharyngeal carcinoma in Vietnam

2020 ◽  
Vol 8 (1) ◽  
pp. 60-67
Author(s):  
Ngo Dong Kha ◽  
Huynh Thi Mong Tuyen ◽  
Lam Hong Ngoc ◽  
Thieu Hong Hue ◽  
Le Quang Anh Tuan ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Initial Data ◽  
Epstein Barr Virus ◽  
Initial Study ◽  
Nucleotide Sequencing ◽  
Potential Contribution ◽  
Barr Virus ◽  
Ebv Infection ◽  
Vietnamese Population ◽  
Epstein Barr

Epstein-Barr virus (EBV) infection is the main cause of Nasopharyngeal Carcinoma (NPC). EBNA-2, one of the most important genes participating in the formation of NPC, also helps EBV evade an attack on the immune system. EBNA-2 has 4 variants including E2-A, E2-B, E2-C and E-2D, of which E2-A and E2-C are the characterized variants for NPC. This study aimed to evaluate the variations of EBNA-2 in NPC biopsy samples of Vietnamese patients. This initial study used 10 biopsy samples, which were positively confirmed to NPC, collected from Cho Ray Hospital. Nested PCR – nucleotide sequencing was applied to analyze the variants of EBNA-2. The results showed that 8 out of 10 samples, accounting for 80%, were positive to EBNA-2. Additionally, only two variants, E-2A and E-2C were detected in our study, in which, E2-A subtype was identified as the predominant subtype. These findings would provide initial data about potential contribution of EBNA-2 polymorphisms to etiology of NPC in Vietnamese population.

scholarly journals Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis

2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Robert J. Ball ◽  
Alison Avenell ◽  
Lorna Aucott ◽  
Peter Hanlon ◽  
Mark A. Vickers
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Epstein Barr Virus ◽  
Meta Analysis ◽  
Barr Virus ◽  
Epstein Barr ◽  
Epidemiological Association

scholarly journals Assessing the potential association between Epstein-Barr virus and oral squamous cell carcinoma: a systematic review and meta- analysis

2020 ◽  
Vol 9 (4) ◽  
pp. 3092-3100 ◽  
Author(s):  
Shivaranjhany Sivakumar ◽  
Archana A. Gupta ◽  
Nik Mohd Mazuan Nik Mohd Rosdy ◽  
Annapurny Venkiteswaran ◽  
A. Thirumal Raj ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epstein Barr Virus ◽  
Meta Analysis ◽  
Barr Virus ◽  
Potential Association ◽  
Epstein Barr

scholarly journals Systematic Review on Epstein-Barr Virus (EBV) DNA in Diagnosis of Nasopharyngeal Carcinoma in Asian Populations

2012 ◽  
Vol 13 (6) ◽  
pp. 2577-2581 ◽  
Author(s):  
Bao-Lin Han ◽  
Xiang-Ying Xu ◽  
Chun-Zhi Zhang ◽  
Jian-Juan Wu ◽  
Chun-Feng Han ◽  
...  
Keyword(s):  
Systematic Review ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Asian Populations ◽  
Ebv Dna ◽  
Epstein Barr

scholarly journals Prevalence of Epstein–Barr virus antibodies in different age groups in Europe and Asia: a systematic review and meta-analysis

2021 ◽  
Vol 65 (3) ◽  
pp. 276-286
Author(s):  
Tatyana V. Solomay ◽  
Tatyana A. Semenenko ◽  
Alexey I. Blokh
Keyword(s):  
Systematic Review ◽  
Growth Rate ◽  
Epstein Barr Virus ◽  
Meta Analysis ◽  
Age Groups ◽  
Maximum Growth ◽  
Small Samples ◽  
Barr Virus ◽  
Cochrane Reviews ◽  
Epstein Barr

Introduction. Attempts to assess the prevalence of antibodies (seroprevalence) to the Epstein-Barr virus have been made several times. Still, a complete understanding of this issue has not been reached due to the small samples of the surveyed. The goal is to evaluate seroprevalence in different age groups in Europe and Asia using a systematic review and meta-analysis. Material and methods. The search for publications was carried out on PubMed, Cochrane Reviews/CochraneLibrary, eLibrary, Cyberleninka, Researchgate from May 6 to 30, 2020. A total of 2,364 articles were found, 12 of which were included in the study. Seroprevalence to Epstein-Barr virus was determined in 67,561 individuals aged 0 to 80 years. The research results were distributed by age groups, continents (Europe and Asia), and their implementation (2000-2012 and 2013-2019) and subjected to meta-analysis. Results. Minimal seroprevalence was detected among children under 1 and 1-2 years of age (53.3 and 50.9%). With increasing age, it grew, and people over 18 years of age were more than 90%. In 2013-2019, the index value (68.9%) was significantly higher than in 2000-2012 (89.6%). In Asian countries in 2000-2019, seroprevalence (86.7%) was considerably higher than in Europe (76.3%). The highest growth rate was observed in 7-14 years. In 2000-2012, the maximum growth rate of seroprevalence occurred in 15-17 years and 2013-2019 - 3-6 years. For all age groups, the growth rate was higher in Europe than in Asia and 2013-2019 compared to 2000-2012. Conclusion. The meta-analysis revealed differences in seroprevalence depending on age and territory of residence and the growth of indices in the trend.

Author response for "The association between Epstein‐Barr virus and oral lichen planus: A systematic review and meta‐analysis"

2020 ◽  
Author(s):  
Sajna Ashraf ◽  
Sadeq Ali Al‐Maweri ◽  
Nader Alaizari ◽  
Ayesha Umair ◽  
Zaihan Ariffin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lichen Planus ◽  
Epstein Barr Virus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Author Response ◽  
Barr Virus ◽  
Epstein Barr ◽  
Oral Lichen
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