scholarly journals Erratum: Blume, C., et al. Modulation of Human Airway Barrier Functions during Burkholderia thailandensis and Francisella tularensis Infection Running Title: Airway Barrier Functions during Bacterial Infections. Pathogens 2016, 5, 53

Pathogens ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 987
Author(s):  
Cornelia Blume ◽  
Jonathan David ◽  
Rachel E. Bell ◽  
Jay R. Laver ◽  
Robert C. Read ◽  
...  
Keyword(s):  
Francisella Tularensis ◽  
Bacterial Infections ◽  
Barrier Functions ◽  
Burkholderia Thailandensis ◽  
Human Airway

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scholarly journals Modulation of Human Airway Barrier Functions during Burkholderia thailandensis and Francisella tularensis Infection

Pathogens ◽  
2016 ◽  
Vol 5 (3) ◽  
pp. 53 ◽  
Author(s):  
Cornelia Blume ◽  
Jonathan David ◽  
Rachel Bell ◽  
Jay Laver ◽  
Robert Read ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Therapeutic Option ◽  
Bacterial Species ◽  
Bronchial Epithelium ◽  
Barrier Properties ◽  
Bronchial Epithelial ◽  
Blocking Antibody ◽  
Burkholderia Thailandensis ◽  
Ionic Permeability ◽  
Tnf Α

The bronchial epithelium provides protection against pathogens from the inhaled environment through the formation of a highly-regulated barrier. In order to understand the pulmonary diseases melioidosis and tularemia caused by Burkholderia thailandensis and Fransicella tularensis, respectively, the barrier function of the human bronchial epithelium were analysed. Polarised 16HBE14o- or differentiated primary human bronchial epithelial cells (BECs) were exposed to increasing multiplicities of infection (MOI) of B. thailandensis or F. tularensis Live Vaccine Strain and barrier responses monitored over 24–72 h. Challenge of polarized BECs with either bacterial species caused an MOI- and time-dependent increase in ionic permeability, disruption of tight junctions, and bacterial passage from the apical to the basolateral compartment. B. thailandensis was found to be more invasive than F. tularensis. Both bacterial species induced an MOI-dependent increase in TNF-α release. An increase in ionic permeability and TNF-α release was induced by B. thailandensis in differentiated BECs. Pretreatment of polarised BECs with the corticosteroid fluticasone propionate reduced bacterial-dependent increases in ionic permeability, bacterial passage, and TNF-α release. TNF blocking antibody Enbrel® reduced bacterial passage only. BEC barrier properties are disrupted during respiratory bacterial infections and targeting with corticosteroids or anti-TNF compounds may represent a therapeutic option.

scholarly journals Alteration of circulating insulin-like growth factors in patients infected with bacteria helicobacter pylori or francisella tularensis

2002 ◽  
Vol 21 (4) ◽  
pp. 339-343
Author(s):  
Ivona Baricevic ◽  
Olgica Nedic ◽  
Anna Nikolic-Judith ◽  
Slavica Marjanovic ◽  
Elizabeta Ristanovic ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Growth Factors ◽  
Francisella Tularensis ◽  
Bacterial Infections ◽  
Bacterial Species ◽  
Igf System ◽  
Igf I ◽  
H Pylori ◽  
Insulin Like Growth Factors

Alterations of insulin-like growth factors (IGF-I and -II) and their binding proteins (IGFBP) in patients infected with Helicobacter pylori or Francisella tularensis are reported in this paper. Infections were diagnosed immunochemically, by determination of specific antibodies to each bacterial species. It was shown that IGF-I, IGF-II and IGFBP-3 concentrations were lower in patients with bacterial infections, while IGFBP-2 concentration increased in comparison with healthy adults. Although the effect was more pronounced in the case of H. pylori infection, statistically significant reductions of IGF-I and IGF-II were found in both groups of patients. For IGF-I p < 0.0001 and for IGF-II p = 0.037 in patients with H. pylori, while p = 0.017 and p = 0.032 in patients with F. tularensis. Alterations of the IGF system can be regarded as a combined effect of bacterial infection on immuno, gastrointestinal hepatobiliary and nutritional axes in the organism.

scholarly journals Differential MicroRNA Analyses of Burkholderia pseudomallei- and Francisella tularensis-Exposed hPBMCs Reveal Potential Biomarkers

2017 ◽  
Vol 2017 ◽  
pp. 1-13
Author(s):  
Regina Z. Cer ◽  
J. Enrique Herrera-Galeano ◽  
Kenneth G. Frey ◽  
Kevin L. Schully ◽  
Truong V. Luu ◽  
...  
Keyword(s):  
Francisella Tularensis ◽  
Burkholderia Pseudomallei ◽  
Bacterial Infections ◽  
Mononuclear Cells ◽  
Early Time ◽  
Differentially Expressed ◽  
Infectious Agents ◽  
Time Points ◽  
Potential Biomarker ◽  
Mirna Species

Increasing evidence that microRNAs (miRNAs) play important roles in the immune response against infectious agents suggests that miRNA might be exploitable as signatures of exposure to specific infectious agents. In order to identify potential early miRNA biomarkers of bacterial infections, human peripheral blood mononuclear cells (hPBMCs) were exposed to two select agents, Burkholderia pseudomallei K96243 and Francisella tularensis SHU S4, as well as to the nonpathogenic control Escherichia coli DH5α. RNA samples were harvested at three early time points, 30, 60, and 120 minutes postexposure, then sequenced. RNAseq analyses identified 87 miRNAs to be differentially expressed (DE) in a linear fashion. Of these, 31 miRNAs were tested using the miScript miRNA qPCR assay. Through RNAseq identification and qPCR validation, we identified differentially expressed miRNA species that may be involved in the early response to bacterial infections. Based upon its upregulation at early time points postexposure in two different individuals, hsa-mir-30c-5p is a miRNA species that could be studied further as a potential biomarker for exposure to these gram-negative intracellular pathogens. Gene ontology functional analyses demonstrated that programmed cell death is the first ranking biological process associated with miRNAs that are upregulated in F. tularensis-exposed hPBMCs.

Intrahepatic Retention of Bile in Severe Bacterial Infections

1964 ◽  
Vol 47 (6) ◽  
pp. 590-599 ◽  
Author(s):  
H. Fahrländer ◽  
F. Huber ◽  
F. Gloor
Keyword(s):  
Bacterial Infections

Lab Tests Find More Infants' Bacterial Infections

2008 ◽  
Vol 42 (7) ◽  
pp. 14
Author(s):  
BETSY BATES
Keyword(s):  
Bacterial Infections

Differential regulation of the transcriptomic and secretomic landscape of sensor and effector funtions of human airway epithelial cells

Pneumologie ◽  
2018 ◽  
Vol 72 (S 01) ◽  
pp. S100-S101
Author(s):  
R Lehmann ◽  
M Müller ◽  
TE Klassert ◽  
D Driesch ◽  
M Stock ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Differential Regulation ◽  
Airway Epithelial ◽  
Human Airway ◽  
Human Airway Epithelial Cells

Prevotella melaninogenica Meningitis and Abscess: A Complication of the Removal of a Midline Dermoid Cyst

2018 ◽  
Vol 15 (03) ◽  
pp. 152-154
Author(s):  
Megan B. Garcia ◽  
Anjali N. Kunz
Keyword(s):  
Dermoid Cyst ◽  
Bacterial Infections ◽  
Surgical Excision ◽  
Sinus Tract ◽  
Neural Tube Closure ◽  
Intracranial Extension ◽  
Dermal Sinus ◽  
Oral Flora ◽  
Prevotella Melaninogenica ◽  
Dermal Sinus Tract

Abstract Prevotella species are gram-negative anaerobic commensal bacteria of the oropharynx, which frequently cause periodontal disease but are otherwise rarely implicated in serious bacterial infections. Cranial dermoid cysts are benign neoplasms that grow along the planes of the embryonic neural tube closure. In infants, they most commonly present in frontal locations, including periorbital, nasal, and within the anterior fontanelle. Although dermoid cysts are slow growing, usually uncomplicated, and easily treated definitively with surgical excision, cranial cysts located on the midline are associated with a higher risk for persistent dermal sinus tract with intracranial extension of the tumor. We describe a case of a 10-month-old male patient with an occipital midline dermoid cyst with intracranial extension, infected with Prevotella melaninogenica, and complicated by intracranial abscess formation and meningitis.This case highlights two unusual disease entities: the uncommon occipital location of a dermoid cyst, and complications of that cyst caused by a serious bacterial infection with a normal oral flora. We discuss the recommendation for neuroimaging prior to surgical excision of a midline dermoid cyst, given the risk for dermal sinus tract with intracranial communication. We also discuss potential mechanisms for bacterial inoculation of this cyst with Prevotella melaninogenica. This pathogen has not previously been reported as a complication of dermoid cysts.

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