scholarly journals Comprehensive Study of the Risk Factors for Medication-Related Osteonecrosis of the Jaw Based on the Japanese Adverse Drug Event Report Database

2020 ◽  
Vol 13 (12) ◽  
pp. 467
Author(s):  
Shinya Toriumi ◽  
Akinobu Kobayashi ◽  
Yoshihiro Uesawa
Keyword(s):  
Risk Factors ◽  
Side Effects ◽  
Adverse Drug Event ◽  
Femoral Fractures ◽  
Principal Component ◽  
Osteonecrosis Of The Jaw ◽  
Drug Event ◽  
Event Report ◽  
Atypical Femoral Fractures ◽  
Antiresorptive Agents

Medication-related osteonecrosis of the jaw (MRONJ) is associated with many drugs, including bisphosphonates (BPs). BPs are associated with atypical femoral fractures and osteonecrosis of the external auditory canal. Thus, many drugs are reported to cause adverse effects on bone. This study aimed to investigate the effects of drugs and patient backgrounds regarding osteonecrosis-related side effects, including MRONJ. This study used a large voluntary reporting database, namely, the Japanese Adverse Drug Event Report database. First, we searched for risk factors related to MRONJ using volcano plots and logistic regression analysis. Next, we searched for bone-necrosis-related side effects using principal component and cluster analysis. Factors that were significantly associated with MRONJ included eight types of BPs and denosumab, prednisolone, sunitinib, eldecalcitol, raloxifene, letrozole, doxifluridine, exemestane, radium chloride, medroxyprogesterone, female, elderly, and short stature. Furthermore, antiresorptive agents (i.e., BPs and denosumab) tended to induce MRONJ and atypical femoral fractures by affecting osteoclasts. We believe these findings will help medical personnel manage the side effects of many medications.

Evaluation of thromboembolic events in cancer patients receiving bevacizumab according to the Japanese Adverse Drug Event Report database

2016 ◽  
Vol 24 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Chikako Matsumura ◽  
Yugo Chisaki ◽  
Satoko Sakimoto ◽  
Honoka Sakae ◽  
Yoshitaka Yano
Keyword(s):  
Risk Factors ◽  
Cancer Patients ◽  
Adverse Drug Event ◽  
Thromboembolic Event ◽  
Venous Thromboembolic Event ◽  
Drug Event ◽  
Thromboembolic Events ◽  
Event Report ◽  
Patients With Cancer ◽  
Venous Thromboembolic

Purpose We aimed to examine the risk factors, time of onset, incidence rates, and outcomes of thromboembolic events induced by bevacizumab in patients with cancer using the Japanese Adverse Drug Event Report (JADER) database of the Pharmaceuticals and Medical Devices Agency. Methods Adverse event data recorded in the JADER database between January 2004 and January 2015 were used. After screening the data using the generic drug name bevacizumab, patient data were classified into two groups by age and five groups by cancer type. The histories of disorders were also categorized. Arterial thromboembolic event and venous thromboembolic event were classified as “favorable” or “unfavorable” outcomes. Results In total, 6076 patients were reported to have developed adverse events during the sample period, of which 233 and 453 developed arterial thromboembolic event and venous thromboembolic event, respectively. Logistic analysis suggested that the presence of cancer was a significant risk factor for both arterial thromboembolic event and venous thromboembolic event. Age (≥70 years), histories of either hypertension or diabetes mellitus were also risk factors for arterial thromboembolic event. Median cumulative times of onset for arterial thromboembolic event and venous thromboembolic event were 60 and 80 days, respectively, and were not significantly different by the log-rank test. By the chi-square test, the rate of unfavorable outcomes was found to be higher after developing arterial thromboembolic event than after venous thromboembolic event. Conclusion Thromboembolism is a leading cause of mortality in patients with cancer. Patients should be monitored for the symptoms of thromboembolic events right from the initial stages of bevacizumab treatment.

scholarly journals Evaluation of medication-related osteonecrosis of the jaw using the Japanese Adverse Drug Event Report database

2018 ◽  
Vol Volume 15 ◽  
pp. 59-64 ◽  
Author(s):  
Ayaka Inada ◽  
Keiko Hosohata ◽  
Saki Oyama ◽  
Iku Niinomi ◽  
Yasuhiro Mori ◽  
...  
Keyword(s):  
Adverse Drug Event ◽  
Osteonecrosis Of The Jaw ◽  
Drug Event ◽  
Event Report

scholarly journals Evaluation of the nature and etiologies of risk factors for diaphyseal atypical femoral fractures

2021 ◽  
Author(s):  
Hiroyuki Tsuchie ◽  
Naohisa Miyakoshi ◽  
Yuji Kasukawa ◽  
Koji Nozaka ◽  
Kimio Saito ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analyses ◽  
Femoral Fractures ◽  
Japanese Patients ◽  
High Serum ◽  
Control Group ◽  
Atypical Femoral Fractures ◽  
Factors Affecting ◽  
Lateral Curvature ◽  
Low Serum

Objectives: Differences in the mechanisms of subtrochanteric and diaphyseal atypical femoral fractures (AFFs) have been speculated in studies that have analyzed differences in the patients’ backgrounds. However, the etiologies of each type of AFF have not been investigated in detail. Therefore, this study aimed to investigate the nature and etiologies of the risk factors for diaphyseal AFFs. Materials and Methods: Eighty consecutive Japanese patients with 91 diaphyseal AFFs (the AFF group) and 110 age-matched female patients with osteoporosis (the non-AFF control group) were included. Their clinical data were compared and the factors affecting AFFs were investigated. Furthermore, the etiologies of the risk factors for diaphyseal AFFs were examined. Results: Multivariate analysis revealed that femoral serrated changes, bisphosphonate or denosumab usage, and lateral and anterior femoral curvatures were the risk factors for diaphyseal AFFs (p<0.0011, p=0.0137, and p<0.0001, respectively). Multivariate analyses also revealed that serrated changes and low serum 25(OH)D levels affected the lateral curvature (p=0.0088 and 0.0205, respectively), while serrated changes affected the anterior curvature (p=0.0006); each significantly affected the femoral curvature. In addition, a high serum calcium (Ca) level, lateral femoral curvature, and anterior femoral curvature were the predictors of serrated changes (p=0.0146, 0.0002, and 0.0098, respectively). Conclusion: The risk factors for diaphyseal AFFs were bone resorption inhibitor usage, a strong femoral curvature, and serrated changes. A low serum 25(OH)D level and serrated changes are the risk factors for lateral curvature, while a high serum Ca level is a risk factor for serrated changes.

scholarly journals Analysis of factors associated with hiccups based on the Japanese Adverse Drug Event Report database

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0172057 ◽  
Author(s):  
Ryuichiro Hosoya ◽  
Yoshihiro Uesawa ◽  
Reiko Ishii-Nozawa ◽  
Hajime Kagaya
Keyword(s):  
Adverse Drug Event ◽  
Drug Event ◽  
Event Report ◽  
Factors Associated

scholarly journals Association between anaphylaxis and anti-influenza drug use: An analysis of the Japanese Adverse Drug Event Report database

2021 ◽  
Vol 15 (3) ◽  
pp. 150-155
Author(s):  
Hiroyuki Tanaka ◽  
Katsuhiro Ohyama ◽  
Yui Horikomi ◽  
Toshihiro Ishii
Keyword(s):  
Drug Use ◽  
Adverse Drug Event ◽  
Drug Event ◽  
Event Report
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