scholarly journals Development of Multifunctional Liposomes Containing Magnetic/Plasmonic MnFe2O4/Au Core/Shell Nanoparticles

Pharmaceutics ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 10 ◽  
Author(s):  
Ana Rodrigues ◽  
Joana Matos ◽  
Armando Nova Dias ◽  
Bernardo Almeida ◽  
Ana Pires ◽  
...  
Keyword(s):  
Quantum Interference ◽  
Lipid Membrane ◽  
Core Shell ◽  
Manganese Ferrite ◽  
Ferrite Core ◽  
Shell Nanoparticles ◽  
Visible Absorption ◽  
The Core ◽  
Gold Core ◽  
Core Shell Nanoparticles

Multifunctional liposomes containing manganese ferrite/gold core/shell nanoparticles were developed. These magnetic/plasmonic nanoparticles were covered by a lipid bilayer or entrapped in liposomes, which form solid or aqueous magnetoliposomes as nanocarriers for simultaneous chemotherapy and phototherapy. The core/shell nanoparticles were characterized by UV/Visible absorption, X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Superconducting Quantum Interference Device (SQUID). The magnetoliposomes were characterized by Dynamic Light Scattering (DLS) and TEM. Fluorescence-based techniques (FRET, steady-state emission, and anisotropy) investigated the incorporation of a potential anti-tumor drug (a thienopyridine derivative) in these nanosystems. The core/shell nanoparticles exhibit sizes of 25 ± 2 nm (from TEM), a plasmonic absorption band (λmax = 550 nm), and keep magnetic character. XRD measurements allowed for the estimation of 13.3 nm diameter for manganese ferrite core and 11.7 nm due to the gold shell. Aqueous magnetoliposomes, with hydrodynamic diameters of 152 ± 18 nm, interact with model membranes by fusion and are able to transport the anti-tumor compound in the lipid membrane, with a high encapsulation efficiency (EE (%) = 98.4 ± 0.8). Solid magnetoliposomes exhibit hydrodynamic diameters around 140 nm and also carry successfully the anticancer drug (with EE (%) = 91.2 ± 5.2), while also being promising as agents for phototherapy. The developed multifunctional liposomes can be promising as therapeutic agents for combined chemo/phototherapy.

Iron Oxide-Gold Core-Shell Nanoparticles as Multimodal Imaging Contrast Agent

2013 ◽  
Vol 13 (6) ◽  
pp. 2341-2347 ◽  
Author(s):  
Luca Menichetti ◽  
Leonardo Manzoni ◽  
Luigi Paduano ◽  
A. Flori ◽  
Claudia Kusmic ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Multimodal Imaging ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Gold Core ◽  
Core Shell Nanoparticles ◽  
Imaging Contrast Agent

Ferrite Core-Shell Nanoparticles Synthesized by Seed-Based Method Characterization and Potential Application

2018 ◽  
Vol 215 (16) ◽  
pp. 1700901
Author(s):  
Urszula Klekotka ◽  
Beata Piotrowska ◽  
Dariusz Satuła ◽  
Michael Giersig ◽  
Beata Kalska-Szostko
Keyword(s):  
Potential Application ◽  
Core Shell ◽  
Ferrite Core ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Preparation of a monolayer array of silica@gold core-shell nanoparticles as a SERS substrate

Optik ◽  
2020 ◽  
Vol 221 ◽  
pp. 165274
Author(s):  
Ciyong Gu ◽  
Shi-Qing Man ◽  
Junqi Tang ◽  
Zhimin Zhao ◽  
Zhenlu Liu ◽  
...  
Keyword(s):  
Core Shell ◽  
Sers Substrate ◽  
Shell Nanoparticles ◽  
Gold Core ◽  
Core Shell Nanoparticles

Aromatic thiol-modulated Ag overgrowth on gold nanoparticles: tracking the thiol's position in the core–shell nanoparticles

Nanoscale ◽  
2019 ◽  
Vol 11 (37) ◽  
pp. 17471-17477 ◽  
Author(s):  
Jiaqi Chen ◽  
Dejing Meng ◽  
Hui Wang ◽  
Haiyun Li ◽  
Yinglu Ji ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Growth Process ◽  
Shell Growth ◽  
Core Shell ◽  
Internal Reference ◽  
Shell Nanoparticles ◽  
Aromatic Thiol ◽  
The Core ◽  
Spatial Trajectory ◽  
Core Shell Nanoparticles

Using DMAB as the Raman internal reference, the spatial trajectory of modulating 4-ATP molecules was tracked during the shell growth process.

Frequency- and Temperature-Dependent Ferromagnetic Resonance of Co/CoO Core-Shell Nanoparticles

2004 ◽  
Vol 818 ◽  
Author(s):  
U. Wiedwald ◽  
J. Lindner ◽  
M. Spasova ◽  
Z. Frait ◽  
M. Hilgendorff ◽  
...  
Keyword(s):  
Ferromagnetic Resonance ◽  
Resonance Field ◽  
Core Shell ◽  
Direct Measure ◽  
Temperature Dependent ◽  
Spin Magnetic Moment ◽  
Shell Nanoparticles ◽  
The Core ◽  
G Value ◽  
Core Shell Nanoparticles

AbstractFerromagnetic Resonance experiments are used to investigate the magnetic properties of monodisperse Co/CoO core-shell nanoparticles with diameters of about 10nm. From frequency- dependent measurements at various frequencies of 9-80 GHz the g-value is determined to be 2.13 which suggests an fcc bulk-like environment of the Co atoms within the core of the particles. This result yields a direct measure of the ratio of orbital to spin magnetic moment νL/νS=0.065. Moreover, from temperature-dependent measurements of the resonance field the anisotropy energy is extracted and found much lower than the hcp bulk value.

Adsorbate-Induced Quenching of Hot Electrons in Gold Core−Shell Nanoparticles

2001 ◽  
Vol 105 (41) ◽  
pp. 9913-9917 ◽  
Author(s):  
S. L. Westcott ◽  
R. D. Averitt ◽  
J. A. Wolfgang ◽  
P. Nordlander ◽  
N. J. Halas
Keyword(s):  
Hot Electrons ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Gold Core ◽  
Core Shell Nanoparticles

PREPARATION AND CHARACTERIZATION OF SURFACE-FUNCTIONALIZATION OF SILICA-COATED MAGNETITE NANOPARTICLES FOR DRUG DELIVERY

NANO ◽  
2014 ◽  
Vol 09 (04) ◽  
pp. 1450042 ◽  
Author(s):  
CONG-WANG ZHANG ◽  
CHANG-CHUN ZENG ◽  
YING XU
Keyword(s):  
Drug Delivery ◽  
Shell Structure ◽  
Drug Carrier ◽  
Point Of View ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
The Core ◽  
Application Potential ◽  
Core Shell Structure ◽  
Core Shell Nanoparticles

Fe 3 O 4– SiO 2 core–shell structure nanoparticles containing magnetic properties were investigated for their potential use in drug delivery. The Fe 3 O 4– SiO 2 core–shell structure nanoparticles were successfully synthesized by a simple and convenient way. The Fe 3 O 4– SiO 2 nanoparticles showed superparamagnetic behavior, indicating a great application potential in separation technologies. From the application point of view, the prepared nanoparticles were found to act as an efficient drug carrier. Specifically, the surface of the core–shell nanoparticles was modified with amino groups by use of silane coupling agent 3-aminopropyltriethoxysilane (APTS). Doxorubicin (DOX) was successfully grafted to the surface of the core–shell nanoparticles after the decoration with the carboxyl acid groups on the surface of amino-modified core–shell structure nanoparticles. Moreover, the nanocomposite showed a good drug delivery performance in the DOX-loading efficiency and drug release experiments, confirming that the materials had a great application potential in drug delivery. It is envisioned that the prepared materials are the ideal agent for application in medical diagnosis and therapy.

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