scholarly journals Liposomal Vitamin D3 as an Anti-aging Agent for the Skin

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 311 ◽  
Author(s):  
Ye Bi ◽  
Hongxi Xia ◽  
Lianlian Li ◽  
Robert J. Lee ◽  
Jing Xie ◽  
...  

Vitamin D3 is an effective skin protective substance to prevent photoaging. Liposomes were used as a carrier to deliver vitamin D3 to improve the stability and to enhance the treatment effect of vitamin D3. The stability of vitamin D3 liposomes, average cumulative penetration, and retention of vitamin D3 in the skin were then evaluated and compared with free vitamin D3. Finally, the treatment effect of vitamin D3 liposomes in a rat photoaging model was appraised and Haematoxylin-Eosin (H&E) staining was used to assess the histology changes of the skin after vitamin D3 liposome treatment. The results indicated that liposomes could significantly improve the stability of vitamin D3. The average skin retention of vitamin D3 liposomes was 1.65 times that of the vitamin D3 solution. Vitamin D3 liposomes could repair the surface morphology of skin in the photoaging model and promote the production of new collagen fibers. Vitamin D3 liposomes as a potential skin care agent could significantly improve skin appearance and repair damage in the histology of photoaging.

2013 ◽  
Vol 52 (2) ◽  
pp. 515-521 ◽  
Author(s):  
Fatoumata Diarrassouba ◽  
Gabriel Remondetto ◽  
Li Liang ◽  
Ghislain Garrait ◽  
Eric Beyssac ◽  
...  

2019 ◽  
Vol 27 (5) ◽  
pp. 374-380
Author(s):  
Vu Huu Vinh ◽  
Huynh Quang Khanh ◽  
Nguyen Hoang Binh ◽  
Nguyen Van Khoi

Background The stability of the pectus bar is an important determinant of the success of pectus excavatum repair surgery. In practice, several different types of fixation method are in use for stabilizing pectus bars. The aim of this study was to compare the performance of the bridge fixation system with previous fixation systems for stabilizing pectus bars. Methods We performed a retrospective review of 1760 pectus excavatum repair cases conducted in the Thoracic Department of Choray Hospital and its satellite hospitals, between 2007 and 2017. We compared the results of 560 patients who had the bridge fixation system with the previous 1200 patients who had other fixation techniques. Results The bridge fixation system with 2 bars in 560 patients gave better results in terms of bar stabilization, operative time, and postoperative complications, compared to the previous 1200 patients who had other stabilization techniques. The average skin-to-skin surgery time using the bridge fixation system was 55 min. Of the 560 cases, only one patient showed trivial one bar dislocation, and one had a postoperative complication (pneumothorax). Conclusions We found the bridge fixation system to be superior not only in terms of stabilizing the bars but also for minimizing the time of surgery and postoperative complications, compared to other fixation systems. The bridge fixation system with 2 bars showed excellent results. Use of 3 bars is not necessary. One bar was used in the other fixation techniques and the results were found to be inferior compared to those using 2 bars.


2009 ◽  
Vol 83 (2) ◽  
pp. 311-317 ◽  
Author(s):  
O. L. Zakharkina ◽  
N. Yu. Ignat’eva ◽  
R. R. Iksanov ◽  
V. A. Kamenskii ◽  
E. N. Sobol’ ◽  
...  

2014 ◽  
Vol 50 (2) ◽  
pp. 361-369 ◽  
Author(s):  
Marilene Estanqueiro ◽  
Jaime Conceição ◽  
Maria Helena Amaral ◽  
Delfim Santos ◽  
João Baptista Silva ◽  
...  

Emulsions are the most common form of skin care products. However, these systems may exhibit some instability. Therefore, when developing emulsions for topical application it is interesting to verify whether they have suitable physical and mechanical characteristics and further assess their stability. The aim of this work was to study the stability of emulsion systems, which varied in the proportion of the emulsifying agent cetearyl alcohol (and) sodium lauryl sulfate (and) sodium cetearyl sulfate (LSX), the nature of the oily phase (decyl oleate, cyclomethicone or dimethicone) and the presence or absence of pumice (5% w/w). While maintaining the samples at room temperature, rheology studies, texture analysis and microscopic observation of formulations with and without pumice were performed. Samples were also submitted to an accelerated stability study by centrifugation and to a thermal stress test. Through the testing, it was found that the amount of emulsifying agent affects the consistency and textural properties such as firmness and adhesiveness. So, formulations containing LSX (5% w/w) and decyl oleate or dimethicone as oily phase had a better consistency and remained stable with time, so exhibited the best features to be used for skin care products.


2015 ◽  
Vol 92 (15) ◽  
Author(s):  
Vincent H.-Y. Chen ◽  
Giuseppe Mallia ◽  
Ruth Martínez-Casado ◽  
Nicholas M. Harrison

2003 ◽  
Vol 782 ◽  
Author(s):  
Kee-Chul Chang ◽  
Jack M. Blakely

ABSTRACTHow the surface morphology of a low index crystal surface evolves under annealing below the roughening temperature is still being investigated both theoretically and experimentally. This research is needed to understand the stability of nanostructures and for the control of step array on surfaces for various technological applications.We have approached this problem from an experimental point of view by looking at the step morphology on the top of mesas patterned on Si(111) after flashing at 1200°C and annealing between 1000–1100°C. We find that after annealing, nanometer height ridges develop on the edges of the mesas except for one edge which becomes a source for steps advancing into the mesa top. The edge that does not develop a ridge is mainly determined by the initial miscut of the surface.We attempt to explain our results through step dynamics and present some applications of this phenomena in creating novel arrays of steps.


2014 ◽  
Vol 778-780 ◽  
pp. 1150-1153
Author(s):  
Hiroyuki Kageshima ◽  
Hiroki Hibino ◽  
Hiroshi Yamaguchi ◽  
Masao Nagase

The energetics for the Si desorption and the C adsorption at a [11-20] step on SiC(0001) surface are studied using the first-principles calculation. It is found that the [11-20] step is stable and nonreactive. The stability of the step is thought to govern the surface morphology during the graphene formation. It is shown that the Si pressure and the temperature are the control parameters for the surface morphology and the graphene quality.


2015 ◽  
Vol 5 (1) ◽  
pp. 79
Author(s):  
Upita Septiani ◽  
Agrina Lisma

 ABSTRACT The utilization of natural zeolite as supporting media of α-amylase enzyme has been done. Natural zeolite which is activated with 3M HCl can remove impurities in the surface natural zeolite, uncover and widen the pores of the zeolite and activate functional groups to interact with α-amylase enzyme in the process of immobilization enzyme process. The mass of activated natural zeolite which is used as a material immobilized to get the optimal activity of α-amylase enzyme was 0.3 gram. Based on the measurement result of optimization of α-amylase enzyme were obtained optimum temperature of 35 oC, pH 5.6 and incubation time of 35 minutes with 0.04845 units/mL of the unit activity. And for α-amylase immobilized enzyme will be stable at the optimum temperature of 50 oC, pH 5.6 and incubation time of 45 minutes with 0.030 units/mL of the unit activity. SEM-EDX pattern shows the differences in surface morphology between natural zeolite and activated natural zeolites which contain α-amylase enzyme. A mobilization technique can increase the stability utilized in a α-amylase enzyme. Keywords : Zeolite, amobilization, α-amylase enzyme


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