scholarly journals Optimising an Infusion Protocol Containing Cefepime to Limit Particulate Load to Newborns in a Neonatal Intensive Care Unit

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 351
Author(s):  
Anthony Martin Mena ◽  
Morgane Masse ◽  
Laura Négrier ◽  
Thu Huong Nguyen ◽  
Bruno Ladam ◽  
...  

Background: In neonatal intensive care units (NICUs), the simultaneous administration of drugs requires complex infusion methods. Such practices can increase the risk of drug incompatibilities resulting in the formation of a particulate load with possible clinical consequences. Methods: This paper evaluates strategies to reduce the particulate load of a protocol commonly used in NICUs with a potential medical incompatibility (vancomycin/cefepime combination). The protocol was reproduced in the laboratory and the infusion line directly connected to a dynamic particle counter to evaluate the particulate matter administered during infusion. A spectrophotometry UV assay of cefepime evaluated the impact of filters on the concentration of cefepime administered. Results: A significant difference was observed between the two infusion line configurations used in the NICU, with higher particulate load for cefepime infused via the emergency route. There was no change in particulate load in the absence of vancomycin. A filter on the emergency route significantly reduced this load without decreasing the cefepime concentration infused. Preparation of cefepime seemed to be a critical issue in the protocol as the solution initially contained a high level of particles. Conclusion: This study demonstrated the impact of a reconstitution method, drug dilution and choice of infusion line configuration on particulate load.

2017 ◽  
Vol 100 (4) ◽  
pp. 710-719 ◽  
Author(s):  
Christian Enke ◽  
Andrés Oliva y Hausmann ◽  
Felix Miedaner ◽  
Bernhard Roth ◽  
Christiane Woopen

2020 ◽  
Vol 10 (30) ◽  
pp. 45-53
Author(s):  
Amanda Raquel Dias Nobre ◽  
Amanda Soares ◽  
Thaynara Filgueiras Ferreira ◽  
Wellyson Souza do Nascimento ◽  
Carla Lidiane Jácome dos Santos ◽  
...  

A assistência qualificada ao recém-nascido prematuro promoveu avanços científicos e tecnológicos que contribuíram para redução da morbimortalidade neonatal. O uso de redes de balanço, a redeterapia pode ajudar no controle da frequência cardíaca e respiração dos bebês, segundo as evidências. O objetivo deste estudo foi verificar a percepção de enfermeiros sobre o uso da redeterapia em recém-nascidos em unidades de cuidados intensivos neonatais. Para isso realizou-se um estudo de campo com abordagem qualitativa, realizado em duas maternidades de referência no cuidado ao recém-nascido. Fizeram parte da amostra vinte profissionais de enfermagem de nível superior do setor de Unidade de Terapia Intensiva Neonatal. A análise dos dados deu-se por técnica de análise do conteúdo proposta por Bardin emergindo duas categorias: Concepções acerca do uso da redeterapia na assistência do enfermeiro ao RNPT; Desafios assistenciais cotidianos frente ao uso da redeterapia por enfermeiros; e benefícios da redeterapia ao RNPT.Descritores: Enfermagem Neonatal, Procedimento Terapêutico, Recém-nascido Prematuro. Redeterapy: a path of perception to applicability by nursesAbstract: Qualified care for premature newborns has promoted scientific and technological advances that have contributed to reducing neonatal morbidity and mortality. The use of balance nets, redeterapia can help control the heart rate and breathing of babies, according to the evidence. The aim of this study was to verify the perception of nurses about the use of redeterapy in newborns in neonatal intensive care units. For this, a field study with a qualitative approach was carried out, carried out in two reference maternity hospitals in the care of the newborn. Twenty high-level nursing professionals from the Neonatal Intensive Care Unit sector were part of the sample. The data analysis was performed using the content analysis technique proposed by Bardin, with two categories emerging: Conceptions about the use of redeterapy in nurses' care for PTNB; Daily care challenges regarding the use of redeterapy by nurses; and benefits of PTN redeterapy.Descriptors: Neonatal Nursing, Therapeutic Procedure, Premature Newborn. Redeterapia: un camino de la percepción a la aplicabilidad por enfermerosResumen: La atención calificada para recién nacidos prematuros ha promovido avances científicos y tecnológicos que han contribuido a reducir la morbilidad y mortalidad neonatal. El uso de redes de equilibrio, redeterapia puede ayudar a controlar la frecuencia cardíaca y la respiración de los bebés, según la evidencia. El objetivo de este estudio fue verificar la percepción de las enfermeras sobre el uso de redeterapia en recién nacidos en unidades de cuidados intensivos neonatales. Para ello, se realizó un estudio de campo con un enfoque cualitativo, realizado en dos hospitales de maternidad de referencia al cuidado del recién nacido. Veinte profesionales de enfermería de alto nivel del sector de la Unidad de Cuidados Intensivos Neonatales formaron parte de la muestra. El análisis de datos se realizó utilizando la técnica de análisis de contenido propuesta por Bardin, con dos categorías emergentes: Concepciones sobre el uso de la redeterapia en la atención de enfermeras para PTNB; Desafíos de atención diaria con respecto al uso de la redeterapia por parte de las enfermeras; y beneficios de la redeterapia PTN.Descriptores: Enfermería Neonatal, Procedimiento Terapéutico, Recién Nacido Prematuro.


2018 ◽  
Vol 25 (3) ◽  
pp. 125-128
Author(s):  
N. E. SHABANOVA ◽  
G. YU. MODEL ◽  
O. G. NI ◽  
I. N. OCHAKOVSKAYA ◽  
L. V. PETROVA

Aim. To compare proportion of different microorganisms in neonatal intensive care units and to assess bacterial susceptibility to antimicrobial agents.Materials and methods. Microbiological monitoring was carried out in neonatal intensive care units (NICU) №1 and №2 of Perinatal center of Krasnodar Region clinical hospital №2.Results. The results of microbiological monitoring demonstrated significant difference in proportions and susceptibility of detected microorganisms.Conclusion. The detected differences determine the need to develop protocols of empirical antimicrobial therapy separately for each medical unit.


Author(s):  
Seyedeh Najmeh Hosseini ◽  
Arash Ghodousi ◽  
Narges Sadeghi ◽  
Somayeh Abbasi

Background: The experience of having neonates in the Neonatal Intensive Care Unit (NICU) is a psychological crisis. It might cause many emotional problems for parents. Entire parental support is among the duties of the healthcare team. Therefore, this study aimed to compare the nursing support received by the mothers with Newborn Abstinence Syndrome (NAS) and the mothers of other neonates admitted to the NICU. Methods: The present cross-sectional descriptive-analytic study was conducted in the selected hospitals in Kerman Province, Iran. In total, 62 mothers with NAS and 61 non-addicted mothers with neonates admitted to the NICU were selected through convenience sampling method. The inclusion criteria were neonates under the care of parents, neonate admitted to the NICU for at least 24 hours, opiate dependence in the case group mothers, and no substance dependence in the control group mothers. The amount of nursing support for mothers having neonates with NAS was compared with that of the control mothers. The study groups were homogenized in terms of the study variables (neonate age, gender, and the duration of hospitalization). The required data were collected by the Nurse-Parent Support Tool (NPST) and analyzed in SPSS. Results: The study results revealed that among the neonates of 123 mothers, 75(60.97%) were boys, and 58(39.02%) were girls. The majority of neonates in both groups were breastfed. The mean±SD age of the mothers in the case and control group were 31.93±7.25 and 28.99±4.36 years, respectively. The nursing support level was desirable in both groups, and no significant difference was found in this regard (P>0.05). Furthermore, the level of nursing support in emotional, information-communication, self-esteem, and quality caregiving support dimensions was desirable in both groups. Conclusion: The obtained results revealed that nurses’ support was desirable in both groups. The prevalence of maternal addiction and the impact of this social harm on neonates who were admitted are essential. Furthermore, families having neonates with NAS need more support from the healthcare staff and nurses, in comparison with healthy parents; thus, the importance of this issue should be addressed in training and briefing courses for nurses.


2003 ◽  
Vol 56 (10) ◽  
pp. 998-1005 ◽  
Author(s):  
Irene E Olsen ◽  
Douglas K Richardson ◽  
Christopher H Schmid ◽  
Lynne M Ausman ◽  
Johanna T Dwyer

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_2) ◽  
Author(s):  
Kaashif A Ahmad ◽  
Christina N Stine ◽  
Jaclyn M LeVan ◽  
Katy L Kohlleppel ◽  
Steven G Velasquez ◽  
...  

Introduction: There is a paucity of data regarding variables that impact the outcome in patients who require cardiopulmonary resuscitation (CPR) in the neonatal intensive care unit (NICU). The impact of initial need or replacement of an existing advanced airway (AA) has not been described in this population. The 2016 Neonatal Resuscitation Program (NRP) places emphasis on AA placement prior to initiating compressions in the delivery room setting. We hypothesized that providers would similarly emphasize airway placement for NICU CPR. Methods: We conducted a retrospective review of patients requiring CPR with chest compressions from 2012 to 2017 across 10 NICUs in San Antonio, Texas. We identified cases by clinician selection of a CPR code and by a review of all patients who died prior to NICU discharge. Results: We review a total of 211 NICU CPR events, 210 of which had complete data regarding the AA. An AA was present at the onset of CPR for 179 (85.2%) of CPR events and an existing airway replaced during CPR for 31 (14.7%) CPR events. All patients without an AA present at onset of CPR had an airway immediately placed. The median time to insertion of AA was 1 minute (IQR 1, 5 minutes). In comparing patients who had an AA present at CPR onset versus absent AA, there was no significant difference in rate of return of spontaneous circulation (ROSC, 63.7% vs 64.5%, p=0.92) or time to ROSC (10.2 vs 12.7 min, p=.66). The median time for replacement of an AA during CPR was 1 minute (IQR 1, 4 minutes). Those with a time to replace the AA of >= 5 minutes had a similar ROSC rate compared to those who had AA replacement in < 5 minutes (75% vs 73.7%, p=.96). The decision to replace an AA during CPR was associated with a non-significant increase in rate of ROSC (74.2% vs 62%, p=0.19) and no significant difference in time to ROSC (11.5 min vs. 10.4 min, p=0.65). Conclusions: The achievement of ROSC or time to ROSC are not impacted by the need to place an initial AA at the onset of CPR or the need to replace the AA during CPR in the NICU. This may be due to the rapid initial placement and replacement of the AA observed in NICU CPR events. These data indicate that NICU CPR providers emphasize rapid AA placement similar to NRP guidelines.


2016 ◽  
Vol 22 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Margaret Doyle Settle

There is growing evidence that continuity of nurse caregivers (CNC) has an effect on outcomes for infants admitted to neonatal intensive care units. Using Levine’s conservation model, the relationship of infant acuity and CNC for 50 infants born between 24 and 40 weeks gestation was explored. A statistically significant difference was found between the variable acuity and CNC (F = 8.65, p = .01). Results suggest that high infant acuity is strongly related to high CNC but may be the effect of a third variable. CNC may support the emergence of physiological, structural, and social competencies for convalescing premature infants.


2019 ◽  
Vol 9 (10) ◽  
pp. 15
Author(s):  
Safaa Abdel Fattah Abou Zed ◽  
Amira Adel Mohammed

Background: Ventilator Associated Pneumonia (VAP) is a common syndrome in pediatrics primarily in infants and early childhood. Mechanical ventilation is one of the leading supportive modalities of management in the intensive care unit, but it conveys a lot of threats and complications. This study aimed to assess the impact of nursing guidelines on nurses’ knowledge and performance regarding to prevention of ventilator associated pneumonia in neonates through the following: 1) Assessment of nurses’ knowledge and performance regarding to prevention of ventilator associated pneumonia in neonates. 2) Designing, implementing and evaluating the impact of nursing guidelines on nurses’ knowledge and performance regarding to prevention of ventilator associated pneumonia in neonates.Methods: Research design: A quasi-experimental design was utilized to conduct this study.  Settings: The study was convoyed at Maternity & Gynecological and Children’s Hospitals affiliated to Ain shams University Hospitals from neonatal intensive care units. Sample: A convenient sample method of forty three (43) nurses, and fifty (50) neonates’ infants on mechanical ventilation was included in the study as a single study group. Tools: The questionnaire format, the observation checklist and implementation of nursing guidelines was assessed the nurses’ knowledge and performance regarding to prevention of ventilator associated pneumonia in neonates. The implementation of nursing guidelines was premeditated as reference guidelines for nurses.Results: There were statistically significant differences between mean scores of the pre and post test as regards nurses’ knowledge and performance regarding to prevention of ventilator associated pneumonia in neonates.Conclusions: Application of the nursing guidelines has a positive outcome on improving nurses’ knowledge and performance regarding to prevention of ventilator associated pneumonia in neonates. Recommendations: The current study recommended that directing a written protocol for prevention of ventilator associated pneumonia in neonates to support satisfactory knowledge, and competent practices are actually required at neonatal intensive care units.


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