scholarly journals In-Depth Comparison of Dry Particle Coating Processes Used in DPI Particle Engineering

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 580
Author(s):  
Nicholas Bungert ◽  
Mirjam Kobler ◽  
Regina Scherließ
Keyword(s):  
Drug Carrier ◽  
Magnesium Stearate ◽  
High Shear ◽  
Particle Engineering ◽  
Dry Powder Inhalation ◽  
Particle Coating ◽  
Lower Drug ◽  
Dry Particle Coating ◽  
Coarse Model ◽  
Carrier Systems

High-shear mixer coatings as well as mechanofusion processes are used in the particle-engineering of dry powder inhalation carrier systems. The aim of coating the carrier particle is usually to decrease carrier–drug adhesion. This study comprises the in-depth comparison of two established dry particle coating options. Both processes were conducted with and without a model additive (magnesium stearate). In doing so, changes in the behaviour of the processed particles can be traced back to either the process or the additive. It can be stated that the coarse model carrier showed no significant changes when processed without additives. By coating the particles with magnesium stearate, the surface energy decreased significantly. This leads to a significant enhancement of the aerodynamic performance of the respective carrier-based blends. Comparing the engineered carriers with each other, the high-shear mixer coating shows significant benefits, namely, lower drug–carrier adhesion and the higher efficiency of the coating process.

scholarly journals Effect of operating conditions on dry particle coating in a high shear mixer

2012 ◽  
Vol 229 ◽  
pp. 97-103 ◽  
Author(s):  
Akira Sato ◽  
Eric Serris ◽  
Philippe Grosseau ◽  
Gérard Thomas ◽  
Alain Chamayou ◽  
...  
Keyword(s):  
Operating Conditions ◽  
High Shear ◽  
Particle Coating ◽  
Dry Particle Coating

Surface Modification of Food Fiber by Dry Particle Coating.

2000 ◽  
Vol 33 (6) ◽  
pp. 848-854 ◽  
Author(s):  
Satoru Watano ◽  
Yasushi Imada ◽  
Kei Miyanami ◽  
Chang-Yu Wu ◽  
Rejesh N. Dave ◽  
...  
Keyword(s):  
Surface Modification ◽  
Particle Coating ◽  
Dry Particle Coating

Lipids-based drug carrier systems by dense gas technology: A review

2012 ◽  
Vol 188 ◽  
pp. 1-14 ◽  
Author(s):  
Chau Chun Beh ◽  
Raffaella Mammucari ◽  
Neil R. Foster
Keyword(s):  
Drug Carrier ◽  
Dense Gas ◽  
Carrier Systems ◽  
Drug Carrier Systems

Biodegradable Polymers as Drug Carrier Systems

2001 ◽  
Author(s):  
Abraham Domb ◽  
Neeraj Kumar ◽  
Tzviel Sheskin ◽  
Alfonso Bentolila ◽  
Joram Slager ◽  
...  
Keyword(s):  
Biodegradable Polymers ◽  
Drug Carrier ◽  
Carrier Systems ◽  
Drug Carrier Systems

scholarly journals Thermo-Mechanical Dry Coating as Dry Coating Process is for Pharmaceuticals

2021 ◽  
Vol 11 (6) ◽  
pp. 176-187
Author(s):  
Mahammed Athar Alli Saikh ◽  
Prithwiraj Mohapatra
Keyword(s):  
Fine Particle ◽  
Coating Process ◽  
High Shear ◽  
Particle Engineering ◽  
Dry Coating ◽  
Ultra Fine Particle ◽  
Working Principle ◽  
Substrate Particle ◽  
Pharmaceutical Processes ◽  
Magnetically Assisted

The manuscript aims to provide glimpse on updated information relating thermo-mechanical dry coating processes (TMDCP) suiting in modifying surface attributes of fine and ultra-fine particle (FiUlFiP). FiUlFiPs are the integral component of pharmaceutical processes. They exhibit complex and queer properties, are conferred mostly from their surface attributes colligated with their higher surface area. Particle engineering technocrats extensively working for modifying surface & surface attributes of FiUlFiPs. These efforts are to find their worthy applications & new functionalities. Among available diverse particle engineering technologies/ process, TMDCP, a dry coating process (DCP), advocated being worthy and efficient. The TMDCP finds multidisciplinary applications, mostly in drug development & drug delivery. Said DCP involves fixing and/or attaching coating material (CoM) as particles herein synonym guest particle (GP) onto core/substrate particle (CSP) herein synonym host particle (HP). Attaching/ fixing the GPs onto HPs, in TMDCP, involve their mechanical and/or thermal interactions. Scientific literatures are evidencing diverse techniques and/or process, basing on discussed interactions. Amongst them novel techniques/ processes are Hybridization, Magnetically assisted impaction coating process (MAICP), Mechanofusion, Theta-composer, and high shear compaction. In this area diverse devices/ equipments are prevailing in market. Important are Hybridizer, Magnetically assisted impaction coater (MAIC), Theta-composer, Mechanofusion, Quadro Comil®, Cyclomix®, and many others. Attempt of this article is to discuss and present their method of working, working principle, applicability, limitations, and benefits. Contained information might be beneficial for professionals of pharmaceutical and allied field. Keywords: dry coating, equipment, particles, processes, thermo-mechanical.

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