scholarly journals Effect of operating conditions on dry particle coating in a high shear mixer

2012 ◽  
Vol 229 ◽  
pp. 97-103 ◽  
Author(s):  
Akira Sato ◽  
Eric Serris ◽  
Philippe Grosseau ◽  
Gérard Thomas ◽  
Alain Chamayou ◽  
...  
Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 580
Author(s):  
Nicholas Bungert ◽  
Mirjam Kobler ◽  
Regina Scherließ

High-shear mixer coatings as well as mechanofusion processes are used in the particle-engineering of dry powder inhalation carrier systems. The aim of coating the carrier particle is usually to decrease carrier–drug adhesion. This study comprises the in-depth comparison of two established dry particle coating options. Both processes were conducted with and without a model additive (magnesium stearate). In doing so, changes in the behaviour of the processed particles can be traced back to either the process or the additive. It can be stated that the coarse model carrier showed no significant changes when processed without additives. By coating the particles with magnesium stearate, the surface energy decreased significantly. This leads to a significant enhancement of the aerodynamic performance of the respective carrier-based blends. Comparing the engineered carriers with each other, the high-shear mixer coating shows significant benefits, namely, lower drug–carrier adhesion and the higher efficiency of the coating process.


2000 ◽  
Vol 33 (6) ◽  
pp. 848-854 ◽  
Author(s):  
Satoru Watano ◽  
Yasushi Imada ◽  
Kei Miyanami ◽  
Chang-Yu Wu ◽  
Rejesh N. Dave ◽  
...  

Author(s):  
Ricardo Cuenca-Alvarez ◽  
Carmen Monterrubio-Badillo ◽  
Fernando Juarez-Lopez ◽  
Hlne Ageorges ◽  
Pierre Fauchais

Polymer ◽  
2020 ◽  
Vol 186 ◽  
pp. 122044
Author(s):  
Shuting Xi ◽  
Peiyao Zhang ◽  
Yajiang Huang ◽  
Miqiu Kong ◽  
Qi Yang ◽  
...  

2014 ◽  
Author(s):  
C. Blümel ◽  
J. Schmidt ◽  
A. Dielesen ◽  
M. Sachs ◽  
B. Winzer ◽  
...  

2012 ◽  
Vol 727-728 ◽  
pp. 1616-1621 ◽  
Author(s):  
Boeira Braga Matheus ◽  
Cristina dos Santos Rocha Sandra

In this research, glass beads with size range between 1.68 and 2mm were coated with 5 polymeric suspensions. The suspensions formulations differ in relation to their employment and physical properties (solids concentration, surface tension and rheology), generating different characteristics of wettability and adhesion with the nucleus. The aim of this study was to evaluate particle coating in a spouted bed through analysis of particle growth in terms of solid surface energy, wettability, and adhesion before and after the formation of the first layer of polymeric film on the particle. The solid-suspension and film-suspension systems were characterized by contact angle and surface energy. The operating conditions were fixed for all suspensions: 1.5 kg of beads, air velocity of 0.369 m/s, air temperature of 60 °C, suspension flow rate of 4 ml and atomizing pressure of 10 psig. Analyzing particle growth kinetics, different behaviors were observed and related not only to glass-suspension wettability, but also to polymeric film-suspension surface properties.


2005 ◽  
Vol 23 (0) ◽  
pp. 139-151 ◽  
Author(s):  
David Cooper ◽  
Chang-Yu Wu ◽  
David Charles Yasensky ◽  
Darryl Butt ◽  
Mei Cai

2001 ◽  
Vol 117 (1-2) ◽  
pp. 40-67 ◽  
Author(s):  
Robert Pfeffer ◽  
Rajesh N Dave ◽  
Dongguang Wei ◽  
Michelle Ramlakhan

2021 ◽  
Vol 12 (4) ◽  
pp. 125
Author(s):  
Hediye Yorulmaz ◽  
Sümeyye Özuzun ◽  
Burak Uzal ◽  
Serhan İlkentapar ◽  
Uğur Durak ◽  
...  

It is known that nano-and microparticles have been very popular in recent years since their advantages. However, due to the very small size of such materials, they have very high tendency to agglomeration particularly for nanoparticles. Therefore, it is critical that they are properly distributed in the system to which they are added. This paper investigated the effects of dry particle coating with nano-and microparticles to solve the agglomeration problem. For a clear evaluation, paste samples were preferred to detemine the compressive strength. Nano-SiO2 and nano-CaCO3, micro-CaCO3 and micro-SiO2, also known as silica fume, were selected as particulate additives. It was studied by the addition of various percentages (0.3, 0.7, 1, 2, 3 and 5%) of nano-and microparticles in cementitious systems, replacing cement by weight with and without dry particle coating. Dry particle coating was made by using a high-speed paddle mixer. Portland cement and additive particles were mixed at 1500 rpm for 30 seconds in high-speed powder mixer designed for this purpose. The 3-day compressive strength of the cement-based samples to which particles were added at the specified rates was determined and the effect of the dry particle coating on the early strength was investigated. According to the results, it was observed that the production of paste with the dry particle coating technique gave higher compressive strength compared to the production of paste directly in early period. Especially with dry particle coating, compressive strength increased more than 100% in paste samples containing 0.3% nano-SiO2 compared to direct addition without coating.


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