scholarly journals Modulation of Hair Growth Promoting Effect by Natural Products

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2163
Author(s):  
Seyeon Park ◽  
Joomin Lee

A large number of people suffer from alopecia or hair loss worldwide. Drug-based therapies using minoxidil and finasteride for the treatment of alopecia are available, but they have shown various side effects in patients. Thus, the use of new therapeutic approaches using bioactive products to reduce the risk of anti-hair-loss medications has been emphasized. Natural products have been used since ancient times and have been proven safe, with few side effects. Several studies have demonstrated the use of plants and their extracts to promote hair growth. Moreover, commercial products based on these natural ingredients have been developed for the treatment of alopecia. Several clinical, animal, and cell-based studies have been conducted to determine the anti-alopecia effects of plant-derived biochemicals. This review is a collective study of phytochemicals with anti-alopecia effects, focusing mainly on the mechanisms underlying their hair-growth-promoting effects.

2020 ◽  
Vol 10 (5) ◽  
pp. 368-375
Author(s):  
Manu Bharti ◽  
Alankar Shrivastav ◽  
M. Abid ◽  
Najam Ali Khan

This review presents an overview on plants identified to possess hair growth activity in various ethno-botanical studies and surveys of tradition medicinal plants. There are various causes for hair loss and the phenomenon is still not fully understood. The treatments offered include both natural or synthetic products to treat the condition of hair loss (alopecia), nonetheless natural products are continuously gaining popularity mainly due to their fewer side effects and better formulation strategies for natural product extracts. Plants have been widely used for hair growth promotion since ancient times as reported in Ayurveda, Chinese and Unani systems of medicine. This review covers information about different herbs and herbal formulation that are believed to be able to reduce the rate of hair loss and at the same time stimulate new hair growth. A focus is placed on their mechanism of action and the review also covers various isolated phytoconstituents possessing hair growth promoting effect. Keywords: Alopecia, ayurveda, hair, herbal formulation.


2017 ◽  
Vol 89 ◽  
pp. 438-446 ◽  
Author(s):  
Zhan-di Wang ◽  
Ying Feng ◽  
Li-yi Ma ◽  
Xian Li ◽  
Wei-feng Ding ◽  
...  

2020 ◽  
Vol 10 (04) ◽  
pp. 176-190
Author(s):  
Glaucia Labinas ◽  
Fernando Amaral ◽  
Valeria Maria de Souza Antunes ◽  
Maira Jardim ◽  
Leonardo Mendes Bella ◽  
...  

2021 ◽  
pp. 118811
Author(s):  
Yingna Li ◽  
Wanwen Yu ◽  
Qingwen Cui ◽  
Jiuyue Liu ◽  
Xuechun Lu ◽  
...  

2013 ◽  
Vol 28 (7) ◽  
pp. 1030-1036 ◽  
Author(s):  
Jintana Junlatat ◽  
Bungorn Sripanidkulchai

2018 ◽  
Vol 19 (9) ◽  
pp. 2703 ◽  
Author(s):  
Bu Choi

The functional aspect of scalp hair is not only to protect from solar radiation and heat/cold exposure but also to contribute to one’s appearance and personality. Progressive hair loss has a cosmetic and social impact. Hair undergoes three stages of hair cycle: the anagen, catagen, and telogen phases. Through cyclical loss and new-hair growth, the number of hairs remains relatively constant. A variety of factors, such as hormones, nutritional status, and exposure to radiations, environmental toxicants, and medications, may affect hair growth. Androgens are the most important of these factors that cause androgenic alopecia. Other forms of hair loss include immunogenic hair loss, that is, alopecia areata. Although a number of therapies, such as finasteride and minoxidil, are approved medications, and a few others (e.g., tofacitinib) are in progress, a wide variety of structurally diverse classes of phytochemicals, including those present in ginseng, have demonstrated hair growth-promoting effects in a large number of preclinical studies. The purpose of this review is to focus on the potential of ginseng and its metabolites on the prevention of hair loss and its underlying mechanisms.


2011 ◽  
Vol 21 (6) ◽  
pp. 1012-1014 ◽  
Author(s):  
Sang-Cheol Kim ◽  
Jung-Il Kang ◽  
Min-Kyoung Kim ◽  
Hye-Jin Boo ◽  
Doek-Bae Park ◽  
...  

2005 ◽  
Vol 38 (2) ◽  
pp. 89-97 ◽  
Author(s):  
S RHO ◽  
S PARK ◽  
S HWANG ◽  
M LEE ◽  
C KIM ◽  
...  

2020 ◽  
Author(s):  
Emer Brady ◽  
Mathias Wullum Nielsen ◽  
Jens Peter Andersen ◽  
Sabine Oertelt-Prigione

Sex and gender differences impact the incidence of SARS-CoV-2 infection and COVID-19 mortality. Furthermore, sex differences characterize the frequency and severity of pharmacological side effects. A large number of clinical trials are ongoing to develop new therapeutic approaches and vaccines for COVID-19. We investigated the inclusion of sex and/or gender in currently registered studies on ClinicalTrials.gov. Only 416 (16.7%) of the 2,484 registered SARS-CoV-2/COVID-19 trials mention sex/gender as recruitment criterion and only 103 (4.1%) allude to sex/gender in the description of the analysis phase. None of the 11 clinical trials published in scientific journals on June 2020 reported sex-disaggregated results. Hence, lack of consideration upon registration does not seem to be corrected during trial execution and reporting. Given the biological relevance and the potential risks of unwanted side effects, we urge researchers to focus on sex-disaggregated analyses already at the planning stage of COVID-19 trials.


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