scholarly journals Synthesis, Characterization and Cytotoxicity of Novel Thermoresponsive Star Copolymers of N,N′-Dimethylaminoethyl Methacrylate and Hydroxyl-Bearing Oligo(Ethylene Glycol) Methacrylate

Polymers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1255 ◽  
Author(s):  
Barbara Mendrek ◽  
Agnieszka Fus ◽  
Katarzyna Klarzyńska ◽  
Aleksander Sieroń ◽  
Mario Smet ◽  
...  

Novel, nontoxic star copolymers of N,N-dimethylaminoethyl methacrylate (DMAEMA) and hydroxyl-bearing oligo(ethylene glycol) methacrylate (OEGMA-OH) were synthesized via atom transfer radical polymerization (ATRP) using hyperbranched poly(arylene oxindole) as the macroinitiator. Stars with molar masses from 100,000 g/mol to 257,000 g/mol and with various amounts of OEGMA-OH in the arms were prepared. As these polymers can find applications, e.g., as carriers of nucleic acids, drugs or antibacterial or antifouling agents, in this work, much attention has been devoted to exploring their solution behavior and their stimuli-responsive properties. The behavior of the stars was studied in aqueous solutions under various pH and temperature conditions, as well as in PBS buffer, in Dulbecco’s modified Eagle’s medium (DMEM) and in organic solvents for comparison. The results indicated that increasing the content of hydrophilic OEGMA-OH units in the arms up to 10 mol% increased the cloud point temperature. For the stars with an OEGMA-OH content of 10 mol%, the thermo- and pH-responsivity was switched off. Since cytotoxicity experiments have shown that the obtained stars are less toxic than homopolymer DMAEMA stars, the presented studies confirmed that the prepared polymers are great candidates for the design of various nanosystems for biomedical applications.

2015 ◽  
Vol 16 (10) ◽  
pp. 3275-3285 ◽  
Author(s):  
Barbara Mendrek ◽  
Łukasz Sieroń ◽  
Iwona Żymełka-Miara ◽  
Paulina Binkiewicz ◽  
Marcin Libera ◽  
...  

2015 ◽  
Vol 6 (26) ◽  
pp. 4801-4808 ◽  
Author(s):  
Jianhua Wu ◽  
Wenmei Liu ◽  
Huijing Han ◽  
Ruyi Sun ◽  
Meiran Xie ◽  
...  

Hyperbranched poly(triazole) bearing oligo(ethylene glycol) terminal groups is dual stimuli-responsive to thermal conditions and metal ions and is capable for the selective absorption of Ag+ ion on tuning temperature.


2020 ◽  
Vol 1 (6) ◽  
pp. 1631-1643
Author(s):  
Rasool Nasseri ◽  
Kam C. Tam

This graphical abstract depicts our hydrogel consisting of hydrazide-functionalized poly(oligo(ethylene glycol) methacrylate) and dialdehyde cellulose nanocrystals and its thermoresponsive and self-healing properties.


RSC Advances ◽  
2014 ◽  
Vol 4 (97) ◽  
pp. 54268-54281 ◽  
Author(s):  
Yinwen Li ◽  
Huilong Guo ◽  
Jian Zheng ◽  
Jianqun Gan ◽  
Yan Zhang ◽  
...  

Schematic illustrations of the thermally-induced self-assembly and possible encapsulation behaviors with single or multi-guests for PE-CD–POEGMAS.


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