scholarly journals Stimuli-responsive hydrogel consisting of hydrazide-functionalized poly(oligo(ethylene glycol)methacrylate) and dialdehyde cellulose nanocrystals

2020 ◽  
Vol 1 (6) ◽  
pp. 1631-1643
Author(s):  
Rasool Nasseri ◽  
Kam C. Tam
Keyword(s):  
Ethylene Glycol ◽  
Cellulose Nanocrystals ◽  
Self Healing ◽  
Stimuli Responsive ◽  
Glycol Methacrylate ◽  
Dialdehyde Cellulose

This graphical abstract depicts our hydrogel consisting of hydrazide-functionalized poly(oligo(ethylene glycol) methacrylate) and dialdehyde cellulose nanocrystals and its thermoresponsive and self-healing properties.

scholarly journals Synthesis, Characterization and Cytotoxicity of Novel Thermoresponsive Star Copolymers of N,N′-Dimethylaminoethyl Methacrylate and Hydroxyl-Bearing Oligo(Ethylene Glycol) Methacrylate

Polymers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1255 ◽  
Author(s):  
Barbara Mendrek ◽  
Agnieszka Fus ◽  
Katarzyna Klarzyńska ◽  
Aleksander Sieroń ◽  
Mario Smet ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Point Temperature ◽  
Glycol Methacrylate ◽  
Dimethylaminoethyl Methacrylate ◽  
Star Copolymers ◽  
Hyperbranched Poly ◽  
Cloud Point Temperature ◽  
Oh Content

Novel, nontoxic star copolymers of N,N-dimethylaminoethyl methacrylate (DMAEMA) and hydroxyl-bearing oligo(ethylene glycol) methacrylate (OEGMA-OH) were synthesized via atom transfer radical polymerization (ATRP) using hyperbranched poly(arylene oxindole) as the macroinitiator. Stars with molar masses from 100,000 g/mol to 257,000 g/mol and with various amounts of OEGMA-OH in the arms were prepared. As these polymers can find applications, e.g., as carriers of nucleic acids, drugs or antibacterial or antifouling agents, in this work, much attention has been devoted to exploring their solution behavior and their stimuli-responsive properties. The behavior of the stars was studied in aqueous solutions under various pH and temperature conditions, as well as in PBS buffer, in Dulbecco’s modified Eagle’s medium (DMEM) and in organic solvents for comparison. The results indicated that increasing the content of hydrophilic OEGMA-OH units in the arms up to 10 mol% increased the cloud point temperature. For the stars with an OEGMA-OH content of 10 mol%, the thermo- and pH-responsivity was switched off. Since cytotoxicity experiments have shown that the obtained stars are less toxic than homopolymer DMAEMA stars, the presented studies confirmed that the prepared polymers are great candidates for the design of various nanosystems for biomedical applications.

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