scholarly journals Influence of the Impregnation Technique on the Release of Esomeprazole from Various Bioaerogels

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1882
Author(s):  
Milica Pantić ◽  
Katja Andrina Kravanja ◽  
Željko Knez ◽  
Zoran Novak
Keyword(s):  
Sol Gel ◽  
In Vitro Dissolution ◽  
Impregnation Method ◽  
Impregnation Technique ◽  
Supercritical Impregnation ◽  
Release Studies ◽  
Sol Gel Synthesis ◽  
Adsorption Desorption ◽  
And Diffusion

The presented study shows the possibility of using bioaerogels, namely neat alginate, pectin, chitosan aerogels, and alginate and pectin aerogels coated with chitosan, as drug delivery systems for esomeprazole. Two different techniques were used for the impregnation of esomeprazole: Supercritical impregnation, and diffusion via ethanol during the sol-gel synthesis. The prepared samples were characterized by employing N2 adsorption-desorption analysis, TGA/DSC, and FTIR. The achieved loadings were satisfactory for all the tested samples and showed to be dependent on the technique used for impregnation. In all cases, higher loadings were achieved when impregnation via diffusion from ethanol was used. Extensive release studies were performed for all impregnated samples. The in vitro dissolution profiles were found to be dependent on the carrier and impregnation method used. Most importantly, in all cases more controlled and delayed release was achieved with the bioaerogels compared to using pure esomeprazole.

scholarly journals UV Imaging for In Vitro Dissolution and Release Studies: Intial Experiences

2014 ◽  
Vol 21 (4) ◽  
Author(s):  
Jesper Østergaard ◽  
Jim Lenke ◽  
Yu Sun ◽  
Fengbin Ye
Keyword(s):  
In Vitro Dissolution ◽  
Uv Imaging ◽  
Release Studies

Gehlenite nanobioceramic: Sol-gel synthesis, characterization, and in vitro assessment of its bioactivity

2018 ◽  
Vol 225 ◽  
pp. 89-92 ◽  
Author(s):  
Mohammad Rafienia ◽  
Ashkan Bigham ◽  
Ahmad Saudi ◽  
Shahram Rahmati
Keyword(s):  
Sol Gel ◽  
In Vitro Assessment ◽  
Sol Gel Synthesis

scholarly journals Diclofenac-β-cyclodextrin binary systems: Physicochemical characterization and in vitro dissolution and diffusion studies

2005 ◽  
Vol 6 (3) ◽  
pp. E464-E472 ◽  
Author(s):  
Maria Letizia Manca ◽  
Marco Zaru ◽  
Guido Ennas ◽  
Donatella Valenti ◽  
Chiara Sinico ◽  
...  
Keyword(s):  
Binary Systems ◽  
Physicochemical Characterization ◽  
In Vitro Dissolution ◽  
Diffusion Studies ◽  
And Diffusion

In vitro dissolution of melt-derived 45S5 and sol-gel derived 58S bioactive glasses

2002 ◽  
Vol 61 (2) ◽  
pp. 301-311 ◽  
Author(s):  
P. Sepulveda ◽  
J. R. Jones ◽  
L. L. Hench
Keyword(s):  
Sol Gel ◽  
In Vitro Dissolution ◽  
Bioactive Glasses

Sol-Gel Synthesis and Characterization of SiO2-CaO-P2O5-SrO Bioactive Glass: In Vitro Study

2014 ◽  
Vol 631 ◽  
pp. 30-35 ◽  
Author(s):  
S. Solgi ◽  
M. Shahrezaee ◽  
A. Zamanian ◽  
T.S. Jafarzadeh Kashi ◽  
Majid Raz ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Mtt Assay ◽  
Sol Gel ◽  
Glass Network ◽  
Biological Properties ◽  
Osteosarcoma Cell ◽  
Three Samples ◽  
Human Osteosarcoma Cell ◽  
Sol Gel Synthesis

Bioactive glass of the type CaO–SrO–P2O5–SiO2was obtained by the sol-gel processing method. Three samples containing 0 mol%, 5 mol% and 10 mol% of SrO were synthesized. The obtained bioactive glasses were characterized by the techniques such as, X-ray diffraction (XRD) and scanning electron microscope (SEM) and the effect of SrO/CaO substitution on in vitro biological properties of the synthesized glasses were evaluated and biocompatibility of the samples was measured using MTT assay. The results showed that incorporation of Sr in the obtained glass network did not result in any structural alteration of it due to the similar role of SrO compared with that of CaO. In vitro experiments with human osteosarcoma cell lines (MG-63) and MTT assay indicated that bioactive glass incorporating 5 mol% of Sr in the composition is non-toxic and revealed good biocompatibility.

Sol–gel synthesis of magnetic TiO2 microspheres and characterization of their in vitro heating ability for hyperthermia treatment of cancer

2015 ◽  
Vol 75 (1) ◽  
pp. 90-97 ◽  
Author(s):  
Gengci Liu ◽  
Masakazu Kawashita ◽  
Zhixia Li ◽  
Toshiki Miyazaki ◽  
Hiroyasu Kanetaka
Keyword(s):  
Sol Gel ◽  
Hyperthermia Treatment ◽  
Tio2 Microspheres ◽  
Sol Gel Synthesis

scholarly journals A sol-gel synthesis, characterization and in vitro bioactivity of binary, ternary and quaternary bioglasses with high mechanical strength

2020 ◽  
Vol 10 (4) ◽  
pp. 310-318
Author(s):  
Sara Bouhazma ◽  
Imane Adouar ◽  
Sanae Chajri ◽  
Smaiel Herradi ◽  
Mohamed Khaldi ◽  
...  
Keyword(s):  
Sol Gel ◽  
Environmental Scanning Electron Microscopy ◽  
Environmental Scanning ◽  
In Vitro Tests ◽  
In Vitro Bioactivity ◽  
X Ray Diffraction ◽  
High Mechanical Strength ◽  
X Ray ◽  
Sol Gel Synthesis

Bioactive powders of the binary SiO2-CaO, ternary SiO2-CaO-P2O5 and quaternary systems SiO2-CaO-P2O5-Na2O/Mg2O were synthesized using a sol-gel route. The gels were converted into bioglasses powders by heat treatments at the temperature of 700°C. The resulting materials were characterized by X-ray diffraction (XRD), Fourier Transform Infrared spectroscopy (FTIR), Environmental Scanning Electron Microscopy (ESEM) and in vitro bioactivity in acellular Simulated Body Fluid (SBF). The in vitro tests showed that the samples had good apatite-forming ability. Glasses doped with sodium and magnesium show good results in terms of bioactivity and mechanical properties. The results showed that the quaternary glass SiO2-CaO-P2O5-Na2O containing Na is the most bioactive, only 6 hours after its immersion in SBF; a layer of hydroxycarbonated apatite (HAC) was deposited on the glass and compressive strength of up to 233.08 MPa with a porosity of 11.02%, due to the presence of the Na2Ca2Si3O9 phase. Magnesium also affects bioactivity because it has improved from binary to ternary to quaternary doped with magnesium, bioactive from 12h of contact with the SBF.

Sol-gel Synthesis of a Novel χSm2Ti2O7/HZSM-5 Composite Photocatalyst for the Promoted Activity on RBR X-3B Degradation

2017 ◽  
Vol 14 (1) ◽  
pp. 17-25
Author(s):  
Wenjie Zhang ◽  
Jiao Yang ◽  
Ling Du
Keyword(s):  
Photocatalytic Activity ◽  
Specific Surface ◽  
Surface Area ◽  
Specific Surface Area ◽  
Sol Gel ◽  
Pyrochlore Phase ◽  
Bandgap Energy ◽  
Powder Materials ◽  
Sol Gel Synthesis ◽  
Adsorption Desorption

Background: Pyrochloro structured Sm2Ti2O7 has photocatalytic activity on degradation of organic substances and on hydrogen evolution from water. Powder materials usually encounter the obstacle of separating from treated water. HZSM-5 zeolite is a kind of porous structured material with large surface area. Its role as a support for Sm2Ti2O7 is interesting. Methods: The supported Sm2Ti2O7 was synthesized using sol-gel method. The composite χSm2Ti2O7/HZSM-5 was characterized by XRD, SEM, TEM, FT-IR/FIR, UV-Vis DRS, N2 adsorption- desorption and XPS measurements. Photocatalytic degradation of Reactive Brilliant Red X-3B (RBR X-3B) was measured to evaluate the activity of the composite. Results: Sm2Ti2O7 is in the pyrochlore phase after loading on the surface of HZSM-5 zeolite. The crystal cell of pyrochlore Sm2Ti2O7 continuously expanses with decreasing Sm2Ti2O7 loading content in the composite. Bandgap energy of Sm2Ti2O7 is enlarged after supporting. The specific surface area of Sm2Ti2O7 was enlarged from 9.8 m2/g to 93 m2/g after loading. Both of the adsorption capacity and photocatalytic activity of the χSm2Ti2O7/HZSM-5 are greater than those of pure Sm2Ti2O7. After 120 min of irradiation, 73.1% of the initial RBR X-3B molecules are decomposed on 70%Sm2Ti2O7/HZSM-5, and only 27.7% of the dye is decomposed on the bare Sm2Ti2O7. Conclusion: Sm2Ti2O7 crystal growth is constrained after loading due to dispersion of Sm2Ti2O7 on the surface of HZSM-5. The specific surface area of Sm2Ti2O7 is significantly enlarged after loading. All the supported samples have greatly enhanced photocatalytic activity as compared to the bare Sm2Ti2O7.

Sign in / Sign up

Export Citation Format

Share Document