Transparent Low Molecular Weight Poly(Ethylene Glycol) Diacrylate-Based Hydrogels as Film Media for Photoswitchable Drugs

In this work, microporous membrane biomaterials based on high weight molecular polylactide (PLA) and low molecular weight poly(ethylene glycol) (PEG) using rapid solvent evaporation method were prepared and investigated. The effect of PEG segments added on the thermal and degradation behaviors was studied. According to the results, produced PLA/PEG biomaterial has lower glass transition temperature (Tg)in comparison with neat PLA. It was also found that the degradation rates of the PLA/PEG biomaterials were significantly increased with adding of PEG, which explained by increasing hydrophilic groups. For better porous fixation, CL-blocked polyisocyanate (CL-bp), which was synthesized from reaction of isophorone diisocyanate (IPDI) with dimethylol propionic acid (DMPA) and Trimethylolpropane (TMP) followed by addition of caprolactam (CL), were introduced. The microporous forms were observed by the scanning electron microscope (SEM), which showed the mean diameters of prepared PLA/PEG microporous were around 10μm.

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Plasticized poly(lactic acid) with low molecular weight poly(ethylene glycol): Mechanical, thermal, and morphology properties

Journal of Applied Polymer Science ◽

10.1002/app.39742 ◽

2013 ◽

pp. n/a-n/a ◽

Cited By ~ 15

Author(s):

Buong Woei Chieng ◽

Nor Azowa Ibrahim ◽

Wan Md Zin Wan Yunus ◽

Mohd Zobir Hussein

Keyword(s):

Molecular Weight ◽

Lactic Acid ◽

Ethylene Glycol ◽

Poly Lactic Acid ◽

Low Molecular Weight ◽

Poly Ethylene Glycol ◽

Poly Ethylene

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Plasticization of poly(lactide) with blends of tributyl citrate and low molecular weight poly(d,l-lactide)-b-poly(ethylene glycol) copolymers

European Polymer Journal ◽

10.1016/j.eurpolymj.2009.07.006 ◽

2009 ◽

Vol 45 (10) ◽

pp. 2839-2848 ◽

Cited By ~ 112

Author(s):

Yahia Lemmouchi ◽

Marius Murariu ◽

Ana Margarida Dos Santos ◽

Allan J. Amass ◽

Etienne Schacht ◽

...

Keyword(s):

Molecular Weight ◽

Ethylene Glycol ◽

Low Molecular Weight ◽

Poly Ethylene Glycol ◽

Poly Ethylene

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External ion accumulation of low molecular weight poly(ethylene glycol) by electrospray ionization fourier transform mass spectrometry

Journal of the American Society for Mass Spectrometry ◽

10.1016/s1044-0305(99)00099-9 ◽

1999 ◽

Vol 10 (12) ◽

pp. 1298-1304 ◽

Cited By ~ 14

Author(s):

E. Peter Maziarz ◽

Gary A. Baker ◽

Sarah A. Lorenz ◽

Troy D. Wood

Keyword(s):

Mass Spectrometry ◽

Molecular Weight ◽

Fourier Transform ◽

Ethylene Glycol ◽

Electrospray Ionization ◽

Fourier Transform Mass Spectrometry ◽

Low Molecular Weight ◽

Poly Ethylene Glycol ◽

Electrospray Ionization Fourier Transform ◽

Poly Ethylene

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Controlling Fluid Diffusion and Release through Mixed-Molecular-Weight Poly(ethylene) Glycol Diacrylate (PEGDA) Hydrogels

Materials ◽

10.3390/ma12203381 ◽

2019 ◽

Vol 12 (20) ◽

pp. 3381 ◽

Cited By ~ 4

Author(s):

Kieran O’Donnell ◽

Adrian Boyd ◽

Brian J. Meenan

Keyword(s):

Tissue Engineering ◽

Molecular Weight ◽

Ethylene Glycol ◽

Mesh Size ◽

Material Structure ◽

Poly Ethylene Glycol ◽

Glycol Diacrylate ◽

Fluorescence Measurements ◽

Fluid Permeability ◽

Poly Ethylene

Due to their inherent ability to swell in the presence of aqueous solutions, hydrogels offer a means for the delivery of therapeutic agents in a range of applications. In the context of designing functional tissue-engineering scaffolds, their role in providing for the diffusion of nutrients to cells is of specific interest. In particular, the facility to provide such nutrients over a prolonged period within the core of a 3D scaffold is a critical consideration for the prevention of cell death and associated tissue-scaffold failure. The work reported here seeks to address this issue via fabrication of hybrid 3D scaffolds with a component fabricated from mixed-molecular-weight hydrogel formulations capable of storing and releasing nutrient solutions over a predetermined time period. To this end, poly(ethylene) glycol diacrylate hydrogel blends comprising mixtures of PEGDA-575 Mw and PEGDA-2000 Mw were prepared via UV polymerization. The effects of addition of the higher-molecular-weight component and the associated photoinitiator concentration on mesh size and corresponding fluid permeability have been investigated by diffusion and release measurements using a Theophylline as an aqueous nutrient model solution. Fluid permeability across the hydrogel films has also been determined using a Rhodamine B solution and associated fluorescence measurements. The results indicate that addition of PEGDA-2000 Mw to PEGDA-575 Mw coupled with the use of a specific photoinitiator concentration provides a means to change mesh size in a hydrogel network while still retaining an overall microporous material structure. The range of mesh sizes created and their distribution in a 3D construct provides for the conditions required for a more prolonged nutrient release profile for tissue-engineering applications.

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