Osteoradionecrosis Rate in Patients Undergoing Radiotherapy for Head and Neck Cancer Treatment: A Six Months Follow-Up of a Perspective Clinical Study

High-dose radiotherapy (RT) for head and neck cancer has significant adverse effects on maxillofacial tissues, among which osteoradionecrosis (ORN) is the most severe and potentially life-threatening. [...]

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Patients' preferences concerning follow‐up after curative head and neck cancer treatment: A cross‐sectional pilot study

Head & Neck ◽

10.1002/hed.25686 ◽

2019 ◽

Vol 41 (7) ◽

pp. 2174-2181 ◽

Cited By ~ 4

Author(s):

Simon Andreas Mueller ◽

Julia Riggauer ◽

Olgun Elicin ◽

Daniela Blaser ◽

Sven Trelle ◽

...

Keyword(s):

Head And Neck Cancer ◽

Pilot Study ◽

Cancer Treatment ◽

Head And Neck ◽

Neck Cancer ◽

Cross Sectional

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Late follow-up of the randomized radiation and concomitant high-dose intra-arterial or intravenous cisplatin (RADPLAT) trial for advanced head and neck cancer

Head & Neck ◽

10.1002/hed.24023 ◽

2015 ◽

Vol 38 (S1) ◽

pp. E488-E493 ◽

Cited By ~ 2

Author(s):

Jolien Heukelom ◽

Marta Lopez-Yurda ◽

Alfons J. M. Balm ◽

Oda B. Wijers ◽

Jan Buter ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

High Dose ◽

Advanced Head

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Oral health of patients undergoing radiotherapy for head and neck cancer treatment: a Preliminary Report of a Prospective Observational clinical study.

Frontiers in Physiology ◽

10.3389/conf.fphys.2019.27.00072 ◽

2019 ◽

Vol 10 ◽

Author(s):

Carlo Lajolo ◽

Cosimo Rupe ◽

Gioele Gioco ◽

Gaetano Paludetti ◽

Francesco Miccichè ◽

...

Keyword(s):

Head And Neck Cancer ◽

Clinical Study ◽

Oral Health ◽

Cancer Treatment ◽

Head And Neck ◽

Neck Cancer ◽

Preliminary Report

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Ultra-High Dose Rate Transmission Beam Proton Therapy for Conventionally Fractionated Head and Neck Cancer: Treatment Planning and Dose Rate Distributions

Cancers ◽

10.3390/cancers13081859 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1859

Author(s):

Patricia van Marlen ◽

Max Dahele ◽

Michael Folkerts ◽

Eric Abel ◽

Ben J. Slotman ◽

...

Keyword(s):

Head And Neck Cancer ◽

Cancer Treatment ◽

Head And Neck ◽

Dose Rate ◽

Neck Cancer ◽

Proton Therapy ◽

High Dose ◽

Plan Quality ◽

Dose Rates ◽

Conventionally Fractionated

Transmission beam (TB) proton therapy (PT) uses single, high energy beams with Bragg-peak behind the target, sharp penumbras and simplified planning/delivery. TB facilitates ultra-high dose-rates (UHDRs, e.g., ≥40 Gy/s), which is a requirement for the FLASH-effect. We investigated (1) plan quality for conventionally-fractionated head-and-neck cancer treatment using spot-scanning proton TBs, intensity-modulated PT (IMPT) and photon volumetric-modulated arc therapy (VMAT); (2) UHDR-metrics. VMAT, 3-field IMPT and 10-field TB-plans, delivering 70/54.25 Gy in 35 fractions to boost/elective volumes, were compared (n = 10 patients). To increase spot peak dose-rates (SPDRs), TB-plans were split into three subplans, with varying spot monitor units and different gantry currents. Average TB-plan organs-at-risk (OAR) sparing was comparable to IMPT: mean oral cavity/body dose were 4.1/2.5 Gy higher (9.3/2.0 Gy lower than VMAT); most other OAR mean doses differed by <2 Gy. Average percentage of dose delivered at UHDRs was 46%/12% for split/non-split TB-plans and mean dose-averaged dose-rate 46/21 Gy/s. Average total beam-on irradiation time was 1.9/3.8 s for split/non-split plans and overall time including scanning 8.9/7.6 s. Conventionally-fractionated proton TB-plans achieved comparable OAR-sparing to IMPT and better than VMAT, with total beam-on irradiation times <10s. If a FLASH-effect can be demonstrated at conventional dose/fraction, this would further improve plan quality and TB-protons would be a suitable delivery system.

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FDG uptake after intraarterial chemotherapy in head and neck cancer

Nuklearmedizin ◽

10.1055/s-0038-1625123 ◽

2006 ◽

Vol 45 (06) ◽

pp. 243-247 ◽

Cited By ~ 2

Author(s):

A. F. Kovács ◽

C. Menzel ◽

K. Engels ◽

W. T. Kranert ◽

F. Grünwald ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Tumor Volume ◽

Lymphatic Drainage ◽

Intraarterial Chemotherapy ◽

High Dose ◽

Positron Emission ◽

Baseline Examination

SummaryAim: The intraarterial chemotherapy (i.a. CHT) using high dose cisplatin combined with systemic neutralization in patients with head and neck cancer (HNSCC) is used to reduce the tumor volume preoperatively. Aim of the study is the evaluation of the influence of i.a. CHT on the metabolism of fluor-18-deoxyglucose (FDG) in the primary and lymph nodes (LN). The value of FDG positron emission tomography (PET) preoperative and as follow-up method after i.a. CHT is examined. Patients, methods: Altogether 16 patients with HNSCC underwent two preoperative FDG PET examinations: the baseline examination one week before and the follow-up three weeks after i.a. CHT. The SUVmax values of the primary and the LN and LN metastases were evaluated and compared with each other and the histopathology. Results: The SUVmax value of the primary decreased after i.a. CHT significantly from a median (25th percentile/ 75th percentile) of 6.4 (4.1/ 7.8) to 3.6 (2.4/ 6.7) (p = 0.01). In 11 out of 16 patients cervical LN metastases were detected. The cervical LN metastases showed a decrease of the SUVmax value from 3.6 (2.3/ 4.8) in the pretreatment examination to 2.3 (1.7/ 3.6) after i.a. CHT (p = 0.008). Only in one patient with LN metastases the SUVmax of the nodes increased. The histopathologically measured size of the LN metastases ranged from 2 to 30 mm. Non malignant LN did not reveal a significant SUVmax decrease after i.a. CHT (p = 0.13). Conclusions: As expected, primaries of HNSCC showed a significant reduction of SUV after i.a. CHT. Compared to the primary the SUVmax decrease in LN metastases was less, but also significant. Since cytotoxic levels of cisplatin do not occur systemic, postinflammatory reactions of the LN or a lymphatic drainage of the chemotherapeutic drug into the LN could be an explanation. PET for staging of HNSCC must thus be performed prior to i.a. CHT.

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